Product Name: 5-Aminolevulinic Acid Phosphate (5ALA)
Chemical Name: 5-Aminolevulinic Acid Phosphate
CAS Number: 868074-65-1
Molecular Formula: C₅H₁₂NO₇P
Molecular Weight: 229.13 g/mol
Appearance: White crystalline powder
Purity: ≥98%
Storage Conditions: Store at room temperature, protected from light and moisture.
Shelf Life: 24 months under proper storage conditions
Packaging: 1 kg per bag
Product Description
5-Aminolevulinic Acid Phosphate (5ALA) is a naturally occurring non-protein amino acid that plays a crucial role in the biosynthesis of heme and chlorophyll in both animals and plants. It is a key intermediate in the tetrapyrrole pathway, which is essential for energy metabolism and cellular function . The phosphate ester form of 5ALA is particularly stable and suitable for various industrial and pharmaceutical applications.
Key Applications
- Pharmaceutical and Medical Use
- 5ALA is used as a precursor for the synthesis of protoporphyrin IX (PpIX), a photosensitizer that is selectively accumulated in tumor cells. This makes it a valuable component in photodynamic therapy (PDT), especially for the treatment of skin cancers and other malignant tumors .
- In neurosurgery, 5ALA is administered orally to enhance the visualization of malignant gliomas during surgery, allowing for more precise tumor resection and improved patient outcomes .
- Research has shown that 5ALA supplementation may have therapeutic potential in treating inflammatory bowel disease (IBD) by modulating immune responses and reducing inflammation .
- Agricultural and Plant Growth Promotion
- 5ALA is used as a plant growth regulator and fertilizer. It promotes chlorophyll synthesis, enhances photosynthesis, and improves crop yield and quality. The phosphate ester form of 5ALA is particularly effective in providing sustained-release nutrition to plants .
- It is also used in the production of animal feed to enhance animal health and reduce the need for antibiotics .
- Cosmetic and Skin Care
- 5ALA is incorporated into skincare products due to its ability to stimulate collagen production, improve skin hydration, and enhance elasticity. It is also used in anti-aging formulations and for the treatment of acne and other skin conditions .
- Food and Feed Industry
- 5ALA is naturally present in many foods, including green vegetables and fermented products. It is used as a food additive and in dietary supplements to support overall health and well-being .
Product Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 5-Aminolevulinic Acid Phosphate |
| CAS Number | 868074-65-1 |
| Molecular Formula | C₅H₁₂NO₇P |
| Molecular Weight | 229.13 g/mol |
| Appearance | White crystalline powder |
| Purity | ≥98% |
| Solubility | Soluble in water (up to 100 mg/mL) |
| Storage Conditions | Store at 2–8°C, protected from light and moisture |
| Shelf Life | 24 months |
| Packaging | 1 kg per bag |
Usage and Handling Precautions
- 5ALA is generally considered safe for use in pharmaceutical, agricultural, and cosmetic applications. However, it is important to follow proper handling and storage guidelines to maintain product stability and efficacy.
- For medical use, 5ALA should be administered under the guidance of a healthcare professional. Patients should avoid exposure to strong light for 24–48 hours after treatment to prevent photosensitivity .
Regulatory and Safety Information
- 5ALA is classified as a Generally Recognized As Safe (GRAS) substance by the U.S. Food and Drug Administration (FDA) for use in food and dietary supplements .
- In pharmaceutical applications, 5ALA is approved for use in photodynamic therapy and is subject to strict regulatory oversight to ensure safety and efficacy .
Conclusion
5-Aminolevulinic Acid Phosphate (5ALA) is a versatile and biologically active compound with a wide range of applications in medicine, agriculture, cosmetics, and food industries. Its unique properties as a precursor to heme and chlorophyll make it an essential component in many natural processes. With its high purity, stability, and broad applicability, 5ALA is a valuable product for both research and commercial use
