Product Name: 7,8-Dihydroxyflavone
CAS Number: 38183-03-8
Molecular Formula: C₁₅H₁₀O₄
Molecular Weight: 254.24
Purity: ≥98% (anhydrous basis)
Appearance: Yellow powder
Solubility:
- DMSO: 50 mg/mL (196.66 mM)
- Ethanol: 1 mg/mL (3.93 mM)
- Water: <1 mg/mL (insoluble)
Product Overview
7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone derived from plants such as Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It is a potent and selective TrkB receptor agonist, with a dissociation constant (Kd) of approximately 320 nM . TrkB is the primary signaling receptor for brain-derived neurotrophic factor (BDNF), a key molecule in neuronal survival, differentiation, and synaptic plasticity .
Key Biological Activities
- Neuroprotection and Cognitive Enhancement
7,8-DHF has been shown to support nerve cell survival, prevent nerve damage, and inhibit apoptosis. It improves memory, learning ability, and overall cognitive function, making it a promising candidate for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease . - Antidepressant and Anxiolytic Effects
By mimicking the function of BDNF, 7,8-DHF may help reduce depressive symptoms and anxiety. It has been shown to dampen the development of a “depressive” phenotype in animal models . - Anti-Inflammatory and Antioxidant Properties
7,8-DHF exhibits anti-inflammatory and antioxidant effects, which help reduce neural inflammation and oxidative stress, protecting the brain from damage . - Promotion of Nerve Regeneration
The compound stimulates nerve regeneration and synaptic plasticity, promoting the restoration and adaptation of brain function . - Iron Homeostasis Modulation
In a recent patent application, 7,8-DHF was found to inhibit iron uptake in Salmonella cells, disrupting iron homeostasis and enhancing the efficacy of colistin in treating bacterial infections . - Nootropic Effects
As a nootropic, 7,8-DHF may improve overall brain health, mood, and cognitive function. It is also beneficial for conditions such as obesity and elevated blood pressure .
Storage and Handling
- Powder Form: Store at -20°C for 3 years.
- In Solvent: Store at -80°C for 2 years.
- General Storage: Keep in a cool, dry, dark location in a tightly sealed container. Avoid exposure to light and air.
- Handling: Wear lab coats and gloves. Avoid inhalation, ingestion, or direct contact with skin or eyes. Do not use in food or beverages.
Usage and Safety
- Research Use Only: This product is strictly for research purposes and not for clinical use.
- Avoid Repeated Freezing/Thawing: To maintain product integrity.
- DMSO Limitations: In cell culture, DMSO should be used at concentrations below 0.3%. In animal experiments, the final concentration of DMSO should not exceed 5% .
- Documentation: Always refer to the latest product documentation for specific handling instructions.
Applications and Research
7,8-DHF is widely used in molecular biology and pharmacology research. It has been studied in various contexts, including:
- Alzheimer’s Disease: 7,8-DHF has shown significant therapeutic potential in reversing memory deficits and BACE1 elevation in mouse models of Alzheimer’s disease .
- Neurodegenerative Diseases: It has been shown to improve spatial memory and increase thin spine density in mouse models of Alzheimer’s disease-like neuronal loss .
- Depression and Anxiety: Intracerebroventricular administration of 7,8-DHF has been shown to prevent the development of depressive phenotypes in animals .
- Antibiotic Synergy: When combined with colistin, 7,8-DHF enhances antibacterial activity against Salmonella by disrupting iron homeostasis .
Conclusion
7,8-Dihydroxyflavone is a versatile and valuable compound with a wide range of biological activities, including neuroprotection, cognitive enhancement, and anti-inflammatory effects. Its selective activation of the TrkB receptor and its role in modulating iron homeostasis make it a promising candidate for the treatment of various neurological and psychiatric disorders. As a research reagent, it is essential to follow proper storage and handling guidelines to ensure its stability and efficacy in experimental settings.
