Acetyl Zingerone

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  • Acetyl Zingerone

Short Description:

Acetyl Zingerone is a phenolic alkanone that is derived from ginger (Zingiber officinale).Acetyl zingerone, also known as 2,4-Pentanedione,3-vanillyl, is an antioxidant derived from ginger that can be used as a “universal antioxidant” because it can scavenge and neutralize a variety of known damaging effects Free radicals for skin health and appearance.It is an all-around active that acts as a potent antioxidant, anti-inflammatory, chelator of transition metals, protector of ECM, scavenger of free radicals, and quencher of high energy DNA-damaging molecules.

Acetyl zingerone, also known as 2,4-Pentanedione,3-vanillyl, is an antioxidant derived from ginger that can be used as a “universal antioxidant” because it can scavenge and neutralize a variety of known damaging effects Free radicals for skin health and appearance. It is synthesized from acetylated zingerone, a compound with enhanced bioavailability and stability. Among other studies, studies on human skin and skin cells show that acetyl zingerone helps offset the negative effects of environmental damage, aids in visibly repairing it, and fosters the skin’s ability to maintain extracellular matrix integrity, acting as a defense against oxidative damage and promoting overall health. Promising candidate for health and well-being. Additionally, it is particularly good at soothing skin exposed to UV rays, interrupting the cascade of damage it causes both on the surface and within the skin. This antioxidant has excellent photostability and can also reduce patchy pigmentation caused by visible spectrum exposure, meaning it helps protect skin from visible light .AZ’s main differentiator is its ability to reduce Dark DNA damage (dark CPD) hours after sun exposure.

 


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
  • E-mail:: info@trbextract.com
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    Product Detail

    Product Tags

    Product Name:Acetyl zingerone

    Other Name:2,4-Pentanedione,3-vanillyl3-Vanillyl-2,4-pentanedione

    3-(4-hydroxy-3-methoxybenzyl)pentane-2,4-dione

    2,4-Pentanedione, 3-((4-hydroxy-3-methoxyphenyl)methyl)-

    3-(3′-Methoxy-4′-hydroxybenzyl)-2,4-pentandion [German]

    3-(3′-Methoxy-4′-hydroxybenzyl)-2,4-pentandion

    CAS No:30881-23-3

    Specifications: 98.0%

    Colour:White powder with characteristic odor and taste

    GMO Status:GMO Free

    Packing: in 25kgs fiber drums

    Storage:Keep container unopened in cool, dry place,Keep away from strong light

    Shelf Life:24 months from date of production

    1. Introduction

    Acetyl Zingerone (AZ), also known as Synoxyl® AZ, is a synthetic derivative of natural compounds found in ginger and turmeric. It is designed to offer superior stability and efficacy compared to its natural counterparts. AZ is a potent antioxidant, anti-inflammatory, and metal-chelating agent that provides broad-spectrum protection against oxidative stress and photoaging. Its unique molecular structure allows it to neutralize a wide range of reactive oxygen species (ROS), including singlet oxygen, superoxide, and peroxynitrite, making it a versatile ingredient for skincare formulations .

    2. Key Benefits of Acetyl Zingerone

    • Photostability: Unlike traditional antioxidants like vitamin E, AZ maintains its efficacy under UV exposure, making it ideal for sun protection and post-sun recovery products .
    • Anti-Aging Properties: AZ helps reverse visible signs of photoaging by reducing wrinkles, pigmentation, and redness. It also supports the skin’s natural ability to maintain the integrity of the extracellular matrix (ECM), promoting a youthful appearance .
    • DNA Protection: AZ prevents the formation of cyclobutane pyrimidine dimers (CPDs), a type of DNA damage associated with skin cancer development. It continues to protect melanocytes even after UV exposure has ended, offering long-lasting protection .
    • Anti-Inflammatory and Anti-Pollution Effects: AZ reduces inflammation and combats the effects of environmental pollutants, such as particulate matter and blue light, which contribute to premature aging .
    • Microbiome Support: AZ helps balance the skin’s microbiome by promoting the growth of beneficial bacteria like Staphylococcus epidermidis and reducing redness and irritation .

    3. Mechanism of Action

    • Antioxidant Activity: AZ scavenges and neutralizes ROS through both sacrificial and non-sacrificial pathways. It acts as a physical quencher of excited states and a selective chelator of transition metals like iron and copper, which are involved in ROS production .
    • Matrix Protection: AZ modulates matrisome activity and inhibits matrix metalloproteinases (MMPs), which break down collagen and elastin in the skin. This helps preserve the skin’s structural integrity and elasticity .
    • Singlet Oxygen Neutralization: AZ stabilizes tetrahexyldecyl ascorbate (THDC), a key antioxidant in skincare, improving its bioavailability and reducing pro-inflammatory effects .

    4. Clinical Efficacy

    • Clinical Studies: A placebo-controlled study demonstrated that 1% AZ significantly improved skin defense, reduced wrinkles, pigmentation, and redness in photoaged skin without the use of sunscreens .
    • Gene Expression and Inflammation: AZ represses IL-17A target gene expression and bolsters matrisome synthesis, contributing to its anti-inflammatory and anti-aging effects .
    • Lipid Peroxidation: Pre-incubation with AZ reduces lipid peroxidation in keratinocyte membranes by up to 88% when exposed to particulate matter .

    5. Formulation and Usage

    • Recommended Usage Levels:Solubility and Compatibility: AZ is highly soluble in solvents such as dimethyl isosorbide, ethanol, and propylene glycol. It is compatible with a wide range of emulsifiers, thickening agents, and UV filters .
      • Antioxidant and Anti-Aging: 0.5–1% for daily skin protection and anti-aging applications.
      • Chelating Agent: 0.1–0.2% for formulations requiring metal ion control.
    • Formulation Tips:
      • Pre-solubilize AZ in the emollient phase with slight heating to avoid crystallization.
      • Add AZ post-emulsification, preferably below 50°C, to maintain its stability.
      • Maintain a formulation pH of ≤6.5 for optimal performance .

    6. Safety and Regulatory Compliance

    • Safety: AZ is REACH-registered (EC# 820-605-0) and is safe for topical application. It does not absorb UV or visible radiation, making it suitable for use in sunscreens and post-sun care products .
    • Regulatory Status: As a cosmetic ingredient, AZ is subject to regulation in the EU and other regions. COSMILE Europe and Sytheon Ltd. provide detailed safety and regulatory information for formulation compliance .

    7. Conclusion

    Acetyl Zingerone is a cutting-edge skincare ingredient that offers a multifunctional approach to anti-aging and environmental protection. Its unique combination of antioxidant, anti-inflammatory, and metal-chelating properties makes it a valuable addition to skincare formulations. With strong scientific backing and clinical efficacy, AZ is poised to become a key player in the skincare industry, addressing the growing demand for effective and stable ingredients that combat the signs of aging and environmental damage

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