Celastrol Powder 98%

Short Description:

Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits significant broad-spectrum anticancer activities for the treatment of a variety of cancers including liver cancer, breast cancer, prostate tumor, multiple myeloma, glioma, etc


  • FOB Price: US $0.5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Payment Terms: L/C,D/A,D/P,T/T
  • :
  • Product Detail

    Product Tags

    Product Name Celastrol bulk powder
    Synonyms Tripterine;Tripterin
    Botanical source The God Vine(Tripterygium wilfordii hook.f)
    CAS NO. 34157-83-0
    Molecular Formula C29H38O4
    Molecular Weight 450.6g/mol
    Appearance Reddish orange crystal powder
    Specification 98%
    Solubility Soluble in organic solvents such as methanol and ethanol
    Benefits Anti-inflammatory, anti-obesity, Neuroprotection, anti-tumor

    What is Tripterygii Radix?

    Celastrol Powder is the active ingredient in Tripterygii Radix, which is the dry root and rhizome of the God Vine. There are four species in total, namely Tripterygium wilfordii Hook.fTripterygium hypoglaucum HutchTripterygium regelii Sprague et Takeda, and Tripterygium forresti Dicls.

    Tripterygium wilfordii Hook. f. and its subspecies Tripterygium hypoglaucum Hutch are mainly used clinically in China. Lei Gong Teng is mainly distributed in Zhejiang, Fujian, Anhui, Jiangxi, Hunan, Taiwan, and other provinces south of the Yangtze River in China.

    Celastrol source from Tripterygii Radix

    Radix Tripterygium wilfordii Hook F main active ingredient

    Diterpenoids: triptolide(cas no.38748-32-2), Tripdiolide( cas no.38647-10-8), etc.

    Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), etc.

    Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, etc.

    What is Celastrol?

    celastrol structure

    Celastrol (Cel) is a highly active pentacyclic triterpene isolated from Lei Gong Teng, which has a variety of pharmacological activities, such as anti-inflammatory, immunosuppressive, anti-obesity, neuron protection, and anti-tumor activities.

    Tripterine was listed as one of the five natural products most likely to be developed into medicine by the top international journal Cell in 2007.

    In 2015, the Umut Ozcan team at Harvard University reported in Cell that research found that Celastrol could significantly reduce the weight of obese mice by increasing the sensitivity of leptin, reducing food intake, and becoming a potential new drug for weight loss, which attracted much attention.

    Pharmacological effects of Celastrol

    Anti-inflammation and immunosuppression

    Plant extract Celastrol powder has already been used in clinical trials for inflammatory illnesses.

    A randomized clinical trial showed that Tripterygium wilfordii Hook F(TwHF) is a suitable option for improving Psoriasis Vulgaris.115 patients were all enrolled (58 TwHF; 57 acitretin). The median PASI score increased in both the TwHF and acitretin groups by 50.4% and 42.7%, respectively.

    Tripterygium wilfordii Hook F and acitretin

    Efficacy of Tripterygium wilfordii Hook F and acitretin. (a) PASI 25 response; (b) PASI 50 response; (c) PASI 75 response; (d) Percentage PASI improvement.

    TwHF and acitretin

    At week 8, the aspartate transaminase and triglyceride levels in the TwHF group were significantly higher than at baseline (P = 0.026 and P = 0.011, respectively).

    Celastrol for Rheumatoid Arthritis

    Celastrol Rheumatoid Arthritis

    The anti-inflammatory properties of celastrol in this condition have so far been attributed to the following:

    (i) regulation of cytokine and chemokine production;

    (ii) regulation of inflammatory mediators’ expression;

    (iii) modulation of inflammatory cell functions;

    (iv) osteoclast modulation and bone damage control


    In hyperleptinemic diet-induced obese (DIO) mice, control reduces food intake, prevents the decrease in energy expenditure, and causes up to 45% weight loss by raising leptin sensitivity.

    Celastrol anti-obesity

    By overexpressing the anorectic peptides proopioid melanocortin (POMC) and orexin [neuropeptide Y (NPY)/AgRP], celastrol can increase leptin sensitivity and restore leptin signaling in neurons.

    Celastrol can improve mitochondrial function and HSF-1, a regulator of energy expenditure, through activating PGC1-dependent metabolic pathways in adipose tissue and muscle.

    These findings indicate Celastrol’s ability to decrease obesity by enhancing leptin sensitivity.


    Celastrol is a promising neuroprotective agent, such as Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis.

    Celastrol induces a broader range of potentially neuroprotective HSPs in differentiated human neurons, including induction of HSP70.

    celastrol HSP70

    Inhibits inflammation by binding to the regulatory NF-kappa-B essential modulator (NEMO) unit in the IKK complex, thereby reducing its activation; binds to TNF receptor-associated factor 6 (TRAF6) and suppresses multiple immune responses.

    Therefore, celastrol has beneficial effects not only in neurodegenerative but also in inflammatory diseases.


    Celastrol’s anticancer effects are related to its activation of cell death, suppression of angiogenesis, treatment, radiotherapy sensitizing action, and anti-invasive effect.

    celastrol pancreatic cancer

    Celastrol’s ability to prevent HSP90 from interacting with its co-chaperone Cdc37 in pancreatic cancer cells causes it to inhibit HSP90.

    Interacting with Cdc37 separates the HSP90-Cdc37 complex, possibly suppressing some carcinogenic proteins.

    celastrol pancreatic cancer HSP90

    Bioavailability of Celastrol

    The solubility of celastrol in water is low (13.25 0.83 mg/ml at 37℃). When Qi et al. (193) investigated the solubility of celastrol in several vehicles, they found that ethyl oleate, olive oil, the surfactants Labrasol and OP-10, and the cosurfactants PEG200, ethanol, butanol, and notably Transcutol P were suitable solvents with a solubility >20 mg/ml.

    Celastrol-loaded lipid nanospheres, liposomal celastrol, and solid self-micro emulsifying dispersible celastrol tablets can significantly increase their oral bioavailability, effectiveness, and side effects.

    Despite encouraging results from both in vitro and in vivo testing, no celastrol product has completed the research and entered the market.

    Toxicity and dosage of Celastrol

    The dose and toxicity of celastrol vary; mouse data at 3 mg/kg showed adverse events and 27% mortality, although other trials at this dose showed no harmful effects.

    Additionally, studies have indicated an LD50 level of 20.5 mg/kg and a 40% fatality rate of 4 mg/kg. An extensive fresh study is also necessary for more exact data.



  • Previous:
  • Next: