Oleanolic Acid Powder

Oleanolic acid dat is in trije pentacyclic triterpenoids isolearre út Gentianaceae planten fan Swertia mileensis de hiele gers of privet fruit, mei in frije lichem en glycosides yn in soad planten. Oleanolic acid hat in breed berik yn de planten, en de gemiddelde ynhâld is 0,2% - 2%. Cucurbitaceae hege ynhâld is 1.5% ~ bult boaiem 2%, privet fruit ynhâld fan 0,6% ~ 0.7% .Oleanolic acid is in soarte fan pentacyclic triterpenoid COMPOUND isolearre fan 'e frucht fan it laach Asteraceae, Syzygium sylvestris, of ligustrum lucidum. It is in leversykte adjuvant en klinysk brûkt foar terapeutyske ynfeksje. Akute Gelbsucht hepatitis hat dúdlik effekten op it ferminderjen fan alanine aminotransferase en yellowing.Oolic acid is in pentacyclic triterpenoids isolearre út de frucht fan swertia chinensis of fructus ligustris út de gentianaceae plant. Oleanolic acid is breed fûn yn planten, mei in algemiene ynhâld fan 0,2% ~ 2% [1]. De ynhâld fan de boaiem fan calabash wie 1,5% ~ 2%, en de ynhâld fan 'e frucht fan fructus ligustris wie 0,6% ~ 0,7%. Oleanolic acid is wyt acicular kristal (ethanol), reukloos en smakeloos. Stabyl mei soeren en bases. Raanpunt fan 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0,15, chloroform, ûnoplosbere yn wetter, oplosber yn methanol, ethanol, Ethyl Ether, aceton en chloroform.Oleanolic acid is in natuerlik foarkommende triterpenoid, in soad ferspraat yn iten en genêskrêftige planten, yn ferbân mei betulinic acid. It kin fûn wurde yn Phytolacca americana (American pokeweed), en Syzygium spp, knyflok, ensfh It is relatyf net-fergiftich, hepatoprotective, en fertoant antitumor en antivirale eigenskippen.
Oleanolic acid wie fûn om te eksposearjen sterke anti-HIV aktiviteit, de besibbe gearstalde betulinic acid waard brûkt foar it meitsjen fan de earste kommersjele maturation inhibitor drug. it waard earst studearre en isolearre út ferskate planten, wêrûnder Rosa woodsii (blêden), Prosopis glandulosa (blêden en twigen), Phordendron juniperinum (hiele plant), Syzygium claviflorum (blêden), Hyptis capitata (hiele plant), en Ternstromia gymnanthera (Aerial part). Oare Syzygium soarten ynklusyf java apple (Syzygium samarangense) en rose apple s befetsje it.

Product Namme: Oleanolic Acid  98 %

Spesifikaasje: 98% by HPLC

Botanic Boarne: Olea Europea Extract

Chemical Namme: (3β) -3-Hydroxyolean-12-en-28-oic acid

CAS No: 508-02-1

Part Used: Leaf

Kleur: White poeder mei karakteristyk geur en smaak

Ggo Status: GMO Free

Packing: Yn 25kgs fibre drums

Storage: Hâld kontener unopened in koele, droege plak, Hâld fuort fan sterke ljocht

Shelf Life: 24 moannen út datum fan produksje

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Funksje:

1.Oleanolic acid is relatyf net-fergiftich, antitumor, en hepatoprotective, likegoed as útstalling antivirale eigenskippen.
2.Oleanolic acid waard fûn om te eksposearjen sterke anti-hiv aktiviteit.
3.Oleanolic acid is in grutte beskermer fan sellen tsjin oxidative en electrophile stress.
4.Oleanolic acid hat grutte ynfloed op trating firus hepatitis, akute icteric hepatitis en gronyske hepatitis.
Oanfraach:
1. Applied yn iten fjild, dan kin fungearret as grûnstoffen tee te ferminderjen phlegm;
2. Applied yn farmaceutische fjild, dan wurdt in nije anti-kanker drug mei lege toxic;
3. Applied yn Cosmetic fjild, it kin invigorate bloedsirkulaasje en ferwiderje drinken.