Gamma-Glutamylcysteine Powder Product Description
Product Overview
Gamma-glutamylcysteine (γ-Glutamylcysteine) is a dipeptide that serves as the direct precursor to glutathione (GSH), a powerful antioxidant and essential molecule in cellular defense systems. This product is widely used in biochemical research, pharmaceutical development, and nutraceutical applications due to its unique properties and biological functions. The powder form of γ-Glutamylcysteine is highly stable and suitable for storage and handling in various experimental settings.
Chemical Properties
- Molecular Formula: C₈H₁₄N₂O₅S
- Molecular Weight: 250.27 g/mol
- CAS Number: 636-58-8
- Appearance: White to off-white powder
- Storage Conditions: Store at -20°C (for long-term stability) or at 2-8°C (for short-term use). Avoid exposure to light and moisture.
- Solubility: Highly soluble in water, with a solubility of ≥10 mg/mL.
Biological Functions
- Antioxidant Activity:
Gamma-glutamylcysteine is the immediate precursor to glutathione (GSH), which is a key antioxidant in the body. By increasing intracellular GSH levels, it enhances the cell’s ability to neutralize reactive oxygen species (ROS), thereby protecting against oxidative stress and cellular damage . - Cell Proliferation and Differentiation:
The regulation of redox balance through γ-Glutamylcysteine influences cell proliferation and differentiation. It plays a role in modulating signaling pathways involved in cell growth and survival . - Biocompatibility:
Gamma-glutamylcysteine exhibits excellent biocompatibility, making it suitable for use in a wide range of cellular and animal models. It is well-tolerated in both in vitro and in vivo studies . - Role in Metabolism and Stress Response:
As a component of the glutathione biosynthesis pathway, γ-Glutamylcysteine is critical for maintaining cellular homeostasis under stress conditions. It is involved in the synthesis of GSH, which is essential for detoxification, immune function, and protection against environmental toxins .
Applications
- Research and Development:
Gamma-glutamylcysteine is extensively used in biochemical and pharmacological studies to investigate antioxidant mechanisms, redox regulation, and the effects of oxidative stress on cellular function . - Pharmaceutical Formulation:
It is used as a precursor in the production of glutathione-based supplements and therapeutic agents. Its role in enhancing antioxidant capacity makes it a valuable component in formulations for conditions associated with oxidative stress, such as neurodegenerative diseases and metabolic disorders . - Nutraceuticals and Dietary Supplements:
In the nutraceutical industry, γ-Glutamylcysteine is marketed as a dietary supplement to support liver health, enhance immune function, and promote overall well-being. It is often combined with other antioxidants to maximize its protective effects .
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name: | Gamma-Glutamylcysteine Powder |
| CAS Number: | 636-58-8 |
| Molecular Formula: | C₈H₁₄N₂O₅S |
| Molecular Weight: | 250.27 g/mol |
| Appearance: | White to off-white powder |
| Purity (HPLC): | ≥98% |
| Storage: | -20°C for long-term storage; 2-8°C for short-term use |
| Solubility: | ≥10 mg/mL in water |
| Shelf Life: | 3 years (unopened); 6 months (in solvent) |
Preparation and Usage
- Stock Solution Preparation:
To prepare a working solution, dissolve the powder in water or a suitable solvent. For example, a 50 mM stock solution can be prepared by dissolving 15.366 g of γ-Glutamylcysteine in 1 L of water and filtering through a 0.22 μm filter to ensure sterility . - Usage in Experiments:
Gamma-glutamylcysteine is commonly used in enzyme assays, cell culture studies, and antioxidant capacity measurements. It is often used in conjunction with other compounds to assess their effects on redox balance and cellular function .
Safety and Handling
- Handling Precautions:
While γ-Glutamylcysteine is generally safe for use in laboratory settings, it is important to follow proper safety protocols, especially when working with high concentrations. Always wear appropriate personal protective equipment (PPE) and work in a well-ventilated area . - Regulatory Compliance:
This product is intended for research use only and should not be used for medical, clinical, or food-related applications. It is not approved for human consumption or therapeutic use .
Conclusion
Gamma-glutamylcysteine is a versatile and essential compound in both research and clinical applications. Its role as a precursor to glutathione makes it a valuable tool in the study of antioxidant mechanisms, cellular stress responses, and metabolic processes. The availability of high-purity powder ensures its reliability in experimental and industrial settings. For further information or technical support, contact our sales team or visit our website for detailed product specifications and usage guidelines.
