Covid-19, ko kuma wanda aka sani da cutar 2019-nCoV ko SARS-CoV-2, na gidan Coronavirus ne. Kamar yadda SARS-CoV-2 na β jinsi na Coronavirus yana da kusanci da MERS-CoV da SARS-CoV - waɗanda suma aka ruwaito suna haifar da mummunan alamomin ciwon huhu a cututtukan da suka gabata. Tsarin halittar kwayar halitta ta 2019-nCoV an siffanta shi kuma an buga shi. [I] [ii] Babban sunadaran wannan kwayar cuta da waɗanda aka gano a baya a cikin SARS-CoV ko MERS-CoV suna nuna babban kamance a tsakaninsu.
Wani sabon abu game da wannan kwayar cutar yana nufin cewa akwai rashin tabbas da yawa game da halayensa, saboda haka ya yi wuri don tantance ko tsire-tsire na tsire-tsire ko mahadi na iya taimakawa ga jama'a a matsayin wakilan prophylactic ko kuma a matsayin abubuwa masu dacewa a cikin kwayoyi masu hana coronavirus akan Covid -19. Koyaya, saboda babban kamanceceniya da Covid-19 tare da ƙwayoyin cuta na SARS-CoV da MERS-CoV da aka ruwaito a baya, binciken da aka buga na baya akan mahaɗan ganye, waɗanda aka tabbatar da yin tasirin anti-coronavirus, na iya zama jagora mai mahimmanci don gano anti-coronavirus tsire-tsire masu tsire-tsire, waɗanda ke iya aiki da kwayar cutar SARS-CoV-2.
Bayan ballewar SARS-CoV, wanda aka fara bayar da rahoto a farkon 2003 [iii], masana kimiyya suna ta ƙoƙari sosai don yin amfani da mahaɗan rigakafin da yawa kan SARS-CoV. Wannan ya sa wasu gwanayen masana a kasar Sin suka binciki kwayoyi masu magani na kasar Sin sama da 200 don ayyukan rigakafin cutar ta wannan kwayar ta coronavirus.
Daga cikin waɗannan, karin abubuwa huɗu sun nuna matsakaici zuwa tasirin hanawa akan SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (a fern), Artemisia annua (Sweet wormwood) da Lindera jimla (ɗan itace mai ɗanɗano mai ƙoshin lafiya a cikin laurel family ). Abubuwan da ke haifar da kwayar cutar sun kasance masu dogaro da kashi kuma sun kasance daga ƙananan ƙididdigar cirewar zuwa sama, suna bambanta ga kowane tsirrai na ganye. Musamman Lycoris radiata ya nuna aikin da ya fi karfi game da kwayar cutar kan kwayar cutar. [Iv]
Wannan sakamakon ya yi daidai da na sauran rukunin binciken guda biyu, wadanda suka nuna cewa wani abu mai aiki wanda yake dauke da tushen Licorice, Glycyrrhizin, an tabbatar da cewa yana da aikin anti-SARS-CoV ta hana shi kwafinsa. [V] [vi] A wani Nazarin, Glycyrrhizin kuma ya nuna aikin rigakafin cutar lokacin da aka gwada shi don maganin cutar ta inviro akan 10 keɓancewar asibiti daban-daban na SARS coronavirus. Baicalin - wani bangare na tsiron Scuttelaria baicalensis (Skullcap) - shima an gwada shi a cikin wannan binciken a cikin yanayi iri ɗaya kuma ya nuna matakan rigakafin cutar ta SARS coronavirus. [Vii] Baicalin shima an nuna ya hana kwayar cutar ta HIV -1 virus a cikin vitro a karatun da suka gabata. [Viii] [ix] Duk da haka ya kamata a lura cewa binciken in vitro ba zai iya zama daidai da ingancin asibiti ba. Wannan saboda yawan baka na wadannan wakili a cikin mutane bazai iya cimma narkar da kwayar jinin ba kamar wanda aka gwada a cikin vitro.
Lycorine ta kuma nuna tsananin kwayar cutar ta SARS-CoV.3 Rahotannin da yawa da suka gabata sun nuna cewa Lycorine kamar tana da manyan ayyukan rigakafin cutar kuma an ba da rahoton cewa ta nuna aikin hanawa kan kwayar cutar ta Herpes Simplex (nau'in I) [x] da Polioyelitis kwayar cutar kuma. [xi]
"Sauran ganyen da aka ba da rahoton sun nuna aikin riga-kafi game da SARS-CoV sune Lonicera japonica (Honeysuckle na Japan) da kuma sanannen tsire-tsire Eucalyptus, da Panax ginseng (tushen) ta hanyar aikin Ginsenoside-Rb1." [Xii]
Shaida daga karatun da aka ambata da kuma wasu karatuttukan karatu na duniya da yawa sun ba da rahoton cewa yawancin masu amfani da ganyayyaki sun nuna ayyukan antiviral da kwayar cutar coronaviruses [xiii] [xiv] kuma babbar hanyar aikinsu ta kasance ta hanyar hana yaduwar kwayar cutar. [Xv] China ya yi amfani da ganyen gargajiyar gargajiyar gargajiyar gargajiyar China sosai don maganin SARS yadda yakamata a lokuta da yawa. [xvi] Sai dai kuma babu wata hujja da za a tabbatar har yanzu game da tasirin asibiti na waɗannan ga masu cutar Covid-19 da ke ɗauke da cutar.
Shin irin waɗannan tsire-tsire masu tsire-tsire za su iya kasancewa masu neman damar ƙirƙirar sababbin magungunan ƙwayoyin cuta don rigakafin ko maganin SARS?
DISCLAMER: An rubuta wannan labarin don dalilai na bayani kawai kuma ba ana nufin maye gurbin shawarar kwararrun likitoci, ganewar asali ko magani ba. Idan kuna tunanin kuna iya samun alamun alamun da suka shafi na Covid-19 ko wata cuta, kira likitan ku nan da nan.
[i] Zhou, P., Yang, X., Wang, X. et al., 2020. Barkewar cututtukan huhu da ke tattare da sabon kwayar cutar corona mai yiwuwa na asalin jemage. Yanayi 579, 270-273 (2020). https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC da Garry, RF, 2020. Asalin kusancin SARS-CoV-2. Yanayi na Yanayi, pp.1-3.
[iii] lokacin amsar CDC SARS. Akwai a https://www.cdc.gov/about/history/sars/timeline.htm. An shiga
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG da Li, RS, 2005. Bayyanar da mahaɗan halitta tare da ayyukan rigakafin cutar coronavirus mai haɗin SARS. Binciken cutar kanjamau, 67 (1), shafi na 18-23.
[v] Cinatl, J., Morgenstem, B. da Bauer, G., 2003. Glycyrrhizin, wani ɓangaren aiki ne na tushen licorice da kuma kwazo na haɗin SARS mai haɗin coronovirus. Lancet, 361 (9374), shafi na 2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW da Cinatl, J., 2005. Ayyukan Antiviral na Glycyrrhizic Acid Kalam SARS− Coronavirus. Jaridar ilmin sunadarai, 48 (4), shafi na 255-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW da Guan, Y., 2004. A cikin vitro mai saukin kamuwa na asibiti na 10 na SARS coronavirus zuwa zaɓaɓɓun mahaɗan antiviral. Jaridar Clinical Virology, 31 (1), shafi na 69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. da Tokunaga, T., 1998. Baicalin, mai hana HIV-1 samarwa a cikin vitro. Binciken rigakafin cutar, 37 (2), shafi na 131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW da Wang, JM, 2000. Flavonoid baicalin ya hana kamuwa da kwayar HIV-1 a matakin shigar kwayar cuta. Kimiyyar halittu da sadarwar bincike ta rayuwa, 276 (2), pp.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. da Kobayashi, S., 1989. Sakamakon alkaloids da aka keɓe daga Amaryllidaceae akan cutar ta herpes simplex virus. Bincike a cikin ilimin kwayar cutar cuta, 140, pp.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. da Alderweireldt, F., 1982. Shuke-shuke masu maganin cutar. III. Rabuwar alkaloids daga Clivia miniata Regel (Amaryl-lidaceae). Jaridar Kayayyakin Halitta, 45 (5), pp.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. da Liang, FS, 2004 Moleananan ƙwayoyin cuta masu niyyar cutar cututtukan numfashi mai saurin cutar kwayar cutar ɗan adam. Ayyukan Cibiyar Kimiyya ta Kasa, 101 (27), shafi na 10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS da Hou, CC, 2007. Specific tsire-tsire masu tsire-tsire da lignoids suna da ƙwayoyin cuta masu ƙarfi game da mummunan cututtukan cututtukan numfashi na coronavirus. Jaridar ilmin sunadarai, 50 (17), shafi na 4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW da Towers, GHN, 1995. Nuna cutar kanjamau na tsire-tsire masu magani na British Columbian. Jaridar Ethnopharmacology, 49 (2), shafi na 101-110.
[xv] Jassim, SAA da Naji, MA, 2003. Novel antiviral agents: tsirrai masu magani. Littafin jarida mai amfani da kwayoyin cuta, 95 (3), shafi na 412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. da Liu, JP, 2020. Shin za a iya amfani da maganin Sinawa don rigakafin cutar kwayar cutar kwarora 2019 (COVID -19)? Binciken tarihin tarihi, shaidar bincike da shirye-shiryen rigakafin yanzu. Jaridar kasar Sin game da Hadakar Magunguna, shafi na 1-8.
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Post lokaci: Apr-18-2020