Beta-nicotinamide Mononucleotide (NMN), wani samfurin na NAMPT dauki da kuma a key nad + tsaka-tsaki, ameliorates glucose rashin ha} uri da tanadi nad + matakai a HFD-jawo T2D beraye. NMN kuma kara habaka hanta insulin ji na ƙwarai kuma ya mayar gene magana alaka oxidative danniya, kumburi amsa, kuma circadian kari, jera ta hanyar SIRT1 kunnawa. NMN da ake amfani da karatu nauyin motifs cikin RNA aptamers da ribozyme kunnawa matakai shafe β-nicotinamide mononucleotide (Beta-NMN) -activated RNA da wani ɓaɓɓake.
Nicotinamide mononucleotide ( "NMN" da "β-NMN") ne a nucleotide samu daga ribose da nicotinamide. Niacinamide (nicotinamide,) shi ne wani nau'i na bitamin B3 (niacin.) Kamar yadda wani biochemical precursor na nad +, shi iya zama da amfani a cikin rigakafin pellagra.
Its Unconcentrated form, niacin, an samu a cikin wani iri-iri sinadirai kafofin: Kirki, Namomin kaza (portobello, gasashen), Avocados, Green Peas (sabo), da kuma wasu kifi da dabbobi nama.
A nazarin [a kan beraye], NMN ya nuna wa baya shekaru da alaka da jijiya tabarbarewa ta ragewa oxidative danniya.
Name: Beta-Nicotinamide Mononucleotide
CAS #: 1094-61-7
Product name: Beta-Nicotinamide Mononucleotide；NMN
Sauran sunan: β-D-NMN. Gwaji-NMN; beta-D-NMN. NMN zwitterion. Nicotinamide Ribotide. Nicotinamide nucleotide. Nicotimide mononucleotide. Nicotinamide mononuclotide
CAS: 1094-61-7
kwayoyin dabara: C11H15N2O8P
kwayoyin Weight: 334,22
Tsarki: 98%
Storage zazzabi: 2-8 ° C
Bayyanar: White foda
amfani: anti-tsufa
aiki:
1.Nicotinamide mononucleotide a ɗan adam Kwayoyin taka muhimmiyar rawa a cikin makamashi ƙarni, shi da hannu a cikin kwayuka nad (nicotinamide adenine dinucleotide, cell makamashi hira muhimmanci coenzyme) kira, a yi amfani da anti-tsufa, fada jini sugar da sauran harkokin kiwon lafiya kayayyakin.
2. Nicotinamide Mononucleotide ne mai ruwa-narkewa bitamin, The samfurin ne fari crystalline foda, odorless ko kusan odorless, m a dandano, da yardar kaina narkewa a cikin ruwa, ko ethanol, dissolvable a glycerin.
3.Nicotinamide Mononucleotide ne sauki sha baka, kuma za a iya yadu rarraba a cikin jiki, da suka wuce haddi metabolites ko samfur da sauri fitar daga fitsari. Nicotinamide ne wani ɓangare na coenzyme na da coenzyme II, taka rawar da hydrogen bayarwa a nazarin halittu hadawan abu da iskar shaka na numfashi sarkar, zai iya gabatar da nazarin halittu hadawan abu da iskar shaka matakai da kuma nama metabolism, kula da al'ada nama (musamman fata, narkewa kamar fili da kuma juyayi tsarin) kirki yana da muhimmiyar rawa .
Bugu da kari, nicotinamide yana da rigakafi da magani daga zuciya block, sinus kumburi aiki da kuma anti-sauri gwaji arrhythmias, nicotinamide iya muhimmanci inganta zuciya kudi da kuma atrioventricular block lalacewa ta hanyar verapamil.
