Product Name: Lupeol Powder
CAS Number: 545-47-1
Molecular Formula: C₃₀H₅₀O
Molecular Weight: 426.72
Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Storage: Store at -20°C to maintain stability and quality
Product Overview
Lupeol is a naturally occurring triterpene found in various plants, including mangoes, acacia, and dandelion coffee. It is a dietary compound with a wide range of biological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. Lupeol is widely used in pharmaceutical, nutraceutical, and cosmetic industries due to its potent health benefits and diverse applications .
Key Features and Applications
1. Anti-Inflammatory and Antioxidant Properties
Lupeol is a powerful anti-inflammatory agent that modulates the interleukin system and inhibits the production of pro-inflammatory cytokines. It also exhibits strong antioxidant activity, which helps protect cells from oxidative stress and damage. These properties make it useful in treating inflammatory conditions such as arthritis, dermatitis, and other inflammatory diseases .
2. Anticancer Activity
Lupeol has shown significant anticancer effects in various studies. It inhibits the growth of hepatocellular carcinoma (HCC) cell lines (e.g., SMMC7721 and HepG2) and melanoma cell lines (e.g., Mel 928 and Mel 1241) with IC₅₀ values of 45–48.5 μM and 75–72 μM, respectively. Additionally, it suppresses tumor promotion induced by benzoyl peroxide in murine skin, demonstrating its potential as a chemopreventive agent .
3. Antimicrobial and Antifungal Effects
Lupeol also exhibits antimicrobial and antifungal activity. It has been shown to reduce the biomass of fungal growth by 40–55% compared to control groups, indicating its potential as a natural antimicrobial agent .
4. Cosmetic and Skin Care Applications
Lupeol is widely used in the cosmetic industry for its anti-angiogenic and skin-repairing properties. It helps in reducing blood pressure in stroke-prone hypertensive rats and decreases the expression of hepatic genes involved in triglyceride and cholesterol synthesis. It also inhibits neutrophil migration in carrageenan-induced edema models, making it a valuable ingredient in skin care products .
5. Industrial and Research Applications
Lupeol is a key component in the development of nutraceuticals, pharmaceuticals, and functional foods. It is used in the formulation of supplements, dietary products, and as a raw material for the production of other triterpene derivatives. Its high purity and stability make it suitable for both in vitro and in vivo research studies .
Safety and Handling
- Storage: Lupeol should be stored at -20°C to ensure long-term stability. If dissolved in a solvent, it should be stored at -80°C for up to 1 year .
- Safety: Lupeol is classified as a laboratory chemical and is not considered hazardous under the 2012 OSHA Hazard Communication Standard. However, it should be handled with care in a well-ventilated area and away from incompatible materials .
- Handling: Lupeol is soluble in organic solvents such as ethanol and dimethyl formamide. It is recommended to purify the solvent before dissolving Lupeol to avoid contamination .
Conclusion
Lupeol Powder is a versatile and valuable compound with a wide range of applications in pharmaceutical, cosmetic, and nutraceutical industries. Its potent anti-inflammatory, antioxidant, and anticancer properties make it a promising candidate for the development of new therapeutic and health-promoting products. With its high purity and stability, Lupeol is an essential ingredient for researchers and manufacturers seeking to harness the natural benefits of triterpenes
