Manufacturer for Isovitexin - Diosmetin 98% – Tong Rui Bio

Diosmetin, CAS 520-34-3, is the aglycone of the flavonoid glycoside diosmin which occurs naturally in citrus fruits. In citrus, there are already many active ingredients commercially available as bulk raw powders, such as hesperidin, diosmin, hesperitin, synephrine, neohesperidin, naringin, methyl hesperidin, methyl hesperidin chalcone, naringin dihydrochalcone, and citrus bioflavonoid, etc. However, diosmetin may be the least popular one among them. All these flavones are generally regarded as safe (GRAS) and used in dietary supplemets formulas, but diosmetin is too new to get noticed.Scientifically known as 3′, 5, 7-trihydroxy-4′-methoxyflavone-7-ramnoglucoside, diosmetin is an O-methylated flavone recognized for its tumor-suppressing capabilities. Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant, oestrogenic and anti-inflamatory activities.

Product Name:Diosmetin 98%

Botanical Source:Citrus aurantium L , Lemon extract

CAS No:520-34-3

Plant Part Used:Fruit

Ingredient: Thymoquinone

Assay: Diosmetin  98% 99% by HPLC

Colour:Yellow brown to Brown fine powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Diosmetin benefits

Diosmetin is the active metabolite of diosmin, and they share similar molecular structures. Diosmin is rapidly hydrolyzed to diosmetin in the intestine with the help of intestinal microflora enzymes. In this sense, the major benefits of diosmin is also diosmetin’s heathy benefits, such as treat chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins, etc., and diosmetin is for more efficient and better than diosmin and micronized diosmin.

Healthy Veins and Legs

As a more efficient diosmin form, diosmetin is a bioflavonoid that is able to reduce the visible signs of varicose and spider veins, as well as alleviate occasional swelling in the legs and ankles known as “heavy legs”.

Diosmetin also enhances the overall health and tone of small veins & capillaries, especially in the legs.

Anti-caner

Diosmetin functions as a human CYP1A enzyme activity inhibitor. Diosmetin inhibits carcinogen activation by inhibiting the CYP1A1 enzyme. Diosmetin has anti-mutagenic and anti-allergic characteristics in vitro, and inhibits tumor growth and protect tumor-induced apoptosis in vivo.

Diosmetin may be also beneficial to treat various inflammations and viral infections. In addition, luteolin and diosmin/diosmetin as novel STAT3 inhibitors for treating autism.

Side effects of diosmetin

For the time being, no supplements containing diosmetin is on the market. No negative effects are reported.

Diosmetin Dosage

No recommended daily dosage for diosmetin at present. No supplements or medicines containing diosmetin are available. Diosmetin is used for reference standards, pharmacological research, food research, cosmetic research, synthetic precursor compounds, intermediates and fine chemicals; it is not popular as an ingredient in food supplements and beverages. However, many of our clients in the United States and the Europe are buying disometin powder from us for their novel supplements already.