Product Name:Nobiletin Powder
Botanic Source:Citrus aurantium L.
CAS No:478-01-3
Colour: White powder with characteristic odor and taste
Specification:≥98% HPLC
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Product Overview
Nobiletin is a naturally occurring polymethoxyflavone, primarily derived from the peels of citrus fruits such as Citrus aurantium (sour orange) and Citrus sinensis (sweet orange). It is a key component of citrus oils and has been extensively studied for its diverse biological activities, including anti-inflammatory, antioxidant, anti-cancer, and neuroprotective properties. Nobiletin is commonly available in powder form, with a 20% extract concentration from Citrus aurantium, making it a popular ingredient in both dietary supplements and pharmaceutical research .
Chemical Properties
Nobiletin has the molecular formula C₂₁H₂₂O₈ and a molecular weight of 402.39 g/mol. It is a white to off-white powder with a high degree of lipophilicity due to its six methoxy groups, which enhance its bioavailability and cellular uptake. The compound is sparingly soluble in water and ether but highly soluble in methanol and other organic solvents. Its CAS number is 478-01-3, and it is also known as Hexamethoxyflavone or 3′,4′,5,6,7,8-Hexamethoxyflavone .
Health Benefits and Uses
Nobiletin is widely recognized for its ability to support cognitive function, particularly by interacting with AMPA receptors in the central nervous system and hippocampal regions, which are essential for synaptic transmission and plasticity. This interaction may help promote memory formation and improve overall brain health . Additionally, Nobiletin has been shown to support circadian rhythms, which regulate sleep-wake cycles and coordinate mental and physical functions .
In terms of metabolic support, Nobiletin helps maintain balanced levels of inflammation and oxidative stress, which are critical for cellular health and longevity. It also promotes cardiovascular function by improving insulin sensitivity and reducing the risk of atherosclerosis . Recent studies have highlighted its potential in preventing high-fat diet-induced dysregulation of intestinal lipid metabolism, particularly in male mice, by enhancing triglyceride clearance and reducing postprandial lipemia .
Anti-inflammatory and Anti-cancer Properties
Nobiletin exhibits strong anti-inflammatory effects by inhibiting the NF-κB signaling pathway, which is a key regulator of inflammation and oxidative stress. It also acts as a potent inhibitor of matrix metalloproteinases (MMPs), which are involved in cancer progression and metastasis . In vitro studies have shown that Nobiletin induces cell cycle arrest and apoptosis in various cancer cell lines, including those of the prostate, breast, and colon . These findings suggest that Nobiletin may have significant potential as a therapeutic agent in cancer treatment .
Safety and Storage
Nobiletin is generally considered safe for use in research and dietary supplements, with no known toxicity at typical dosages. However, it is important to note that it should only be used for research purposes and not for clinical applications. The recommended storage conditions for Nobiletin powder are room temperature for short-term use and 2–8°C for long-term storage. It should be protected from strong light and kept in airtight containers to prevent degradation .
Dosage and Usage
As a dietary supplement, Nobiletin is typically recommended at a dosage of 250 mg per day, with a purity of at least 98%. It is often combined with other compounds to enhance its effects, such as DMAE L-Bitartrate for cognitive function, Tart Cherry for cardiovascular support, and Berberine HCL + Silymarin for metabolic function . The powder form is convenient for mixing into beverages, capsules, or other formulations .
Conclusion
Nobiletin is a versatile and powerful compound with a wide range of health benefits, supported by extensive research in both preclinical and clinical settings. Its natural origin, combined with its high bioavailability and safety profile, makes it a valuable ingredient in both dietary supplements and pharmaceutical applications. Whether used to support cognitive function, cardiovascular health, or metabolic balance, Nobiletin offers a promising solution for promoting overall well-being
