Oleoylethanolamide(OEA)

Dzina mankhwala:  Oleoylethanolamide , N-Oleoylethanolamide , OEA
Other dzina:  N- (2-hydroxyethyl) -9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide, N- (2-hydroxyethyl) oleamide
CAS No:  111-58-0
maselo Formular:  C ₂₀H ₃₉NO ₂
maselo Kulemera kwake: 325,5
zofufuza: 90%, 95%, 85% Mph
Maonekedwe: kirimu yofiira ufa

Oleoylethanolamide is something new to the nutritional market as a popular dietary supplement ingredient used in weight loss formulas. Many bodybuilding fans are discussing oleoylethanolamide on reddit and other social networking platforms.

Oleoylethanolamide ndi metabolite zachilengedwe asidi oleic anapangidwa mu intestine kochepa thupi. Iwo amakhala occuring, ndipo akatswiri icho "amkati".

OEA is a natural regulator of appetite, weight and cholesterol. It is a natural metabolite that is made in small amounts in your small intestine. OEA helps regulate hunger, weight, body fat and cholesterol by binding to a receptor known as PPAR-Alpha (Peroxisome proliferator-activated receptor alpha). In essence, OEA increases the metabolism of body fat and tells your brain that you are full and it’s time to stop eating. OEA is also known to increase non-exercise related calorie expenditure.

Oleylethanolamide History

Oleoylethanolamide ndi ntchito kwachilengedwenso ankagwidwa mwamsanga zaka 50 zapitazo. Pamaso 2001, panalibe kufufuza zambiri pa OEA. Komabe, chaka kuti, ofufuza Spanish Anaphwanya zamadzimadzi ndi kuphunzira mmene chapangidwa, kumene ntchito ndi chimene izo zimachita. Iwo anawayesa zotsatira za OEA pa ubongo (a makoswe) ndi jekeseni mwachindunji mu ventricles ubongo. Sanapeze zotsatira kudya ndi kutsimikizira kuti OEA sachita mu ubongo, koma izo akapsa mbendera osiyana imagwira njala ndi kudya khalidwe.

Oleylethanolamide vs cannabinoid anandamide

Zotsatira za OEA anayamba kuphunzira chifukwa amauza kufanana ndi mankhwala wina cannabinoid kudziwika monga anandamide. Cannabinoids zokhudza chomera mankhwala, ndipo anandamides alipo chomera (ndi chamba) angadwale chikhumbo cha munthu kuti akamwe zoziziritsa kukhosi ndi kudzipheralo ndi kudya ayankhe. Malinga ndi Wikipedia, Oleoylethanolamide ndi analogue monounsaturated wa anandamide endocannabinoid. Ngakhale OEA ali ndi dongosolo mankhwala kuti ndi ofanana anandamide, zotsatira zake kudya ndi kasamalidwe kulemera ndi osiyana. Mosiyana anandamide, OEA amachita popanda cannabinoid njira, malamulo ntchito PPAR-α yotithandiza lipolysis.

Structures of various fatty-acid ethanolamides: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) and anandamide (arachidonoylethanolamide, AEA). (Cima Science Co., Ltd is the only manufacturer of bulk raw materials of OEA, PEA and AEA in China, if you need sample and price quote, please drop us an email in the contact us page.)

OEA chimango ndi kuyandikana mkulu kwa peroxisome-proliferator-adamulowetsa cholandilira-ndi (PPAR-a), ndi lilime nyukiliya kuti nthawi mbali zosiyanasiyana za kagayidwe zamadzimadzi.

zachilengedwe a oleoylethanolamide

Oleoylethanolamide ndi metabolite zachilengedwe asidi oleic. Choncho, zakudya containg asidi oleic ndi gwero mwachindunji OEA.

asidi Oleic ndi mafuta makamaka masamba mafuta monga maolivi, canola ndi mpendadzuwa. asidi Oleic akhoza kupezeka mafuta nati, nyama, nkhuku, tchizi, etc.

magwero zakudya wolemera asidi oleic monga: canola Mafuta, mafuta a azitona, mapeyala Mafuta, mchiwu Mafuta, mapeyala, High Oleic Safflower Mafuta

Mfundo Zina za Oleic Acid:

Mmodzi wa mafuta ambiri mu mkaka wa m'mawere anthu

Amapanga 25% ya mafuta mu mkaka wa ng'ombe

Monounsaturated

asidi Omega-9 mafuta

Chemical ndiyo njira C18H34O2 (CAS 112-80-1)

Wopachikidwa ndi triglycerides

Ntchito zodzoladzola mkulu wogulira monga moisturizer kwambiri

Anapeza mafuta mkaka, cheese, mafuta, mafuta grapeseed, mtedza, mapeyala, mazira ndi nyama

Akhoza kukhala odalirika ambiri wathanzi mafuta!

Ndipamene wapamwamba ngwazi maofesi ndi mapuloteni ena mkaka kulimbana maselo a khansa

Oleoylethanolamide Ubwino

Oleoylethanolamide (OEA) Ndi bwino kuonda monga kudya yang'anira ndipo amathandiza wathanzi mafuta milingo akuluakulu.

OEA monga kudya suppressant

Chilakolako yimitsira ndi lalikulu yolamulira imene mphamvu (chakudya) madyedwe, yosamalira kudya n'kofunika kulamulira thupi lathanzi kulemera. Kodi OEA controlyour kudya? Mukhoza onani limagwirira cha zochita pansipa.

OEA ndi mafuta

mafuta ndi opsa zakudya, ndipo amathandiza m'munsi "oipa" LDL mafuta ndi kuonjezera "zabwino" HDL. Chifukwa chiyani? Mpaka 85% ya mafuta ndi asidi oleic, ndi chachikulu wathanzi metabolite asidi oleic ndi OEA (Oleoylethanolamide ndi dzina zonse). Choncho, palibe angatsutse kuti OEA amathandiza healty mafuta.

Ena rereearch limasonyeza kuti oleoylethanolamide ali Phindu pa nkhawa, ndi kudutsa ndi umboni zofunika kuthandiza.

Manufacutring ndondomeko ya Oleoylethanolamide

The flow char of Oleoylethanolamide is below:

masitepe Genral ndi: reactiong → ayeretsedwe ndondomeko → kusefera → Re-kusungunuka Mowa → hydrogenation → filtrate Chotsani Phula → crystallization → kusefera → Kuyesedwa → atanyamula → Mapeto Mafotokozedwe

Limagwirira cha zochita za oleoylethanolamide

Kunena mwachidule, oleoylethanolamide ntchito monga njala yang'anira. OEA amatha kulamulira kudya chakudya chanu pomuuza ubongo kuti thupi zonse, ndipo palibe chakudya pakufunika zambiri. Inu kudya zochepa tsiku lililonse, ndipo thupi lanu zikhoza si onenepa pamapeto pake.

Zochita odana ndi kunenepa kwa oleoylethanolamide (OEA) ndi monga tikuonera chithunzi. OEA ndi apanga ndi asonkhanitsidwa mu proximal intestine yaing'ono kuchokera ku asidi oleic zakudya-linachokera, monga mafuta a azitona. Zamafuta zakudya akhoza ziletsa OEA kupanga mu intestine lapansi. OEA kumachepetsa kudya chakudya ndi mphamvu homeostatic oxytocin pamene ndi histamine ubongo circuitry komanso hedonic dopamine njira. Pali umboni kuti OEA amathanso attenuate hedonic cannabinoid cholandilira 1 (CB1R) ma siginalo, kutsegula amene amagwirizana ndi kuchuluka kudya chakudya. OEA kumachepetsa zamadzimadzi zoyendera mu adipocytes kuti ndichepe misa mafuta. Komanso elucidation obwera chifukwa cha OEA pa kudya chakudya ndi zamadzimadzi kagayidwe chiti chomwe chingathandize mu mtima wa asilikali thupi kuti akhoza akulimbana kukhala aluso kunenepa mankhwala.

OEA ntchito yambitsa chinachake wotchedwa PPAR ndi imodzi ndiziwunda mafuta-yoyaka ndi amachepetsa yosungirako mafuta. Pamene mudya, OEA milingo Kuonjezera ndi chilakolako chanu amachepetsa pamene misempha imalandira olumikizana ubongo wanu ndikuuzeni kuti ndinu zonse. PPAR-α ndi gulu la ligand-adamulowetsa cholandilira nyukiliya kuti nawo mawu losokonekera wa zamadzimadzi kagayidwe ndi energyhomeostasis njira.

OEA wawonetsera kwa makhalidwe liwulo wa satiety Chinthu:

(1) kumabwezera mmbuyo kudyetsa ndi kutalikitsa ndi imeneyi kwa chakudya lotsatira;

(2) kaphatikizidwe wake malamulo ndi kupezeka michere ndi

(3) milingo Zake kukumana kusinthasintha circadian.

Zotsatira Oleoylethanolamide mbali

chitetezo Oleoylethanolamide ndi nkhawa lalikulu pakati zopangidwa enaake amene mukufuna kuyesa izi pophika buku mu kuwonda mitunduyi awo.

Kenako titakambirana mabuku mabuku onse amene alipo ndi deta ya US zakudya ndi mankhwala Administration (FDA) analibe nkhawa zokhudza chitetezo OEA a. RiduZone ndi woyamba kuwasindikiza oleoylethanolamide ufa pophika kuyambira 2015.

Oleoylethanolamide ndi metabolite asidi oleic, omwe ali mbali ya wathanzi zakudya tsiku. Tikhoza kuyesa OEA zowonjezera, ndi zoopsa mavuto zalembedwa.

Zotsatira zalembedwa.

mayesero Oleoylethanolamide anthu

Mu phunziro lina, makumi asanu (n = 50) nzika anthu chidwi kuonda anauzidwa kuti atenge OEA 2-3 / tsiku, mphindi 15-30 pamaso chakudya kwa milungu 4-12. Nzika m'gulu amene si ntchito kuwonda mankhwala pamaso, amene zinthu zosangalatsa chowawa ndi mankhwala ena kuwonda, omwe mlingo imfa plateaued pa atumiki kuwonda monga fentamini, amene atanganidwa m'moyo kusintha (kuyang'anira gawo ndi masewera olimbitsa thupi ), ndipo anthu mwachangu kuti anakwanitsa kwa matenda kuphatikizapo shuga kulolerana bwino dyslipidemia, matenda oopsa ndi matenda a mtima.

Mu phunziro lachiwiri, 4 nzika zolemera ziriri a 229, 242, 375 ndi 193 lbs motero, anauzidwa kuti atenge Oleoylethanolamide makapisozi (kapisozi m'modzi okhala 200mg 90% OEA). Nzika anatenga 4 makapisozi (1 kapisozi Mphindi 15-30 musanadye ndipo iwo anali kuchita kapisozi owonjezera asanayambe kudya waukulu wa tsiku) tsiku kwa masiku 28. Phunziro lomaliza poyamba akukonza chilolo gulu kuyika. Nzika anauzidwa kuti palibe kusintha kwa zakudya ndi zinthu zolimbitsa thupi lawo makhalidwe.

zotsatira

Mu phunziro loyamba, anthu anataya avareji lbs 1-2 / sabata. Panali zotsatira palibe mbali kupatula wodwala mmodzi akukumana chosakhalitsa nseru kuti linathera pasanathe sabata. Mu kuphunzira chachiwiri, 3 kunja kwa nzika 4 lipoti kuwonda (3, 7, 15 0 lbs motero). olamulidwa 4 lipoti 10-15% kuchepa kukula gawo intervals yaitali yapakati-chakudya, ndipo zotsatira palibe mbali.

Ngati mukufuna mabuku mayesero anthu ndi OEA, chonde pitani dawunilodi limasonyeza PDF.

Oleoylethanolamide mlingo

Pali zochepa kafukufuku mudziwe panopa OEA supplementation anthu, ndipo pamene ankaona otetezedwa, palibe mlingo analimbikitsa. Komabe, pali ena zowonjezera pa msika, ndipo mudzaona ena pakuyenerera wanu.

The dosing patsiku la RiduZone (kuwasindikiza OEA / Oleoylethanolamide 90%) ndi 200mg (1capsule okha OEA mmenemo). Ngati ziziwayendera pamodzi ndi ena zosakaniza kuwonda, ndi dosing tsiku zikuoneka kuti zochepa, kunena 100mg kapena 150mg. Somesupplements

Ndi bwino kutenga oleoylethanolamide zowonjezera mphindi 30 asanayambe kudya ndi chakudya, mudzakhala wathunthu kwambiri pa chakudya ndi chifukwa mosakayika kudya zochepa.

Research mabuku oleoylethanolamide

Oleoylethanolamide: watsopano player akulamulira mphamvu kagayidwe. Mbali kudya chakudya

Oleoylethanolamide kumawonjezera mawu a PPAR-Α ndipo kumachepetsa kudya thupi anthu akunenepa: A mayesero matenda

Brain mamolekyulu ndi kudya: nkhani ya Oleoylethanolamide

Oleylethanolamide nthawi kudya ndi thupi mwa kutsegula kwa nyukiliya cholandilira PPAR-ndi

Kutsegula wa TRPV1 ndi Satiety Factor Oleoylethanolamide

Lamulo kudya chakudya ndi oleoylethanolamide

Limagwirira wa oleoylethanolamide pa mafuta asidi kutengedwa mu intestine yaing'ono pambuyo kudya chakudya ndi thupi kuchepetsa kulemera

Oleoylethanolamide: Ntchito ya zamadzimadzi bioactive amidein modulating kudya khalidwe

Oleoylethanolamide: A angakuthandizeni mafuta polimbana kunenepa

Oleoylethanolamide: A buku Angathe pharmacological Njira kuti Cannabinoid muzikangana kwa Control chilakolako