Original Factory Grape Seed Extract And Breast Cancer - 2019 New Style Top Chamomile Extract Apigenin Powder Cas No 520-36-5 Apigenin 98% – Tong Rui Bio
Original Factory Grape Seed Extract And Breast Cancer - 2019 New Style Top Chamomile Extract Apigenin Powder Cas No 520-36-5 Apigenin 98% – Tong Rui Bio Detail:
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“Quality initial, Honesty as base, Sincere company and mutual profit” is our idea, so that you can create consistently and pursue the excellence for 520-36-5, Apigenin, Apigenin Powder, Our objects have national accreditation requirements for qualified, high quality items, affordable value, was welcomed by people today all over the world. Our goods will continue to enhance within the order and look forward to cooperation with you, Should really any of those products and solutions be of interest to you, be sure to letus know. We’ve been planning to be content to provide you a quotation up on receipt of your detailed needs.
Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.
Product Name:Celery leaf extract Apigenin 98%
Latin Name:Apium graveolens L.
Plant Part Used:Leaf
Assay:Apigenin 98.0% by HPLC
Colour:Brown to yellow powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Apigenin plays an essential role in cancer prevention by inducing apoptosis in various cell lines.
Some research was found that apigenin could inhibit the growth, proliferation, and transfer of ca-ov3 (human ovarian cancer cell); it induces apoptosis of ca-ov3 through keeping the cancer cells stasis in G2/M phase. The effect is related to time and dose.
Apigenin can inhibit the proliferation of pancreatic cancer cells. Apigenin starves the tumor by reducing the source of glucose, which is the food on which cancers cells live. Besides, Apigenin can improve the effectiveness of the chemotherapy drug- gemcitabine.
It was found that apigenin in low content had a low cytotoxic effect and could not induce human acute myeloid leukemia (hl-60) cells to apoptosis effectively. However, apigenin can enhance the inhibitory effect of cisplatin (DDP) on hl-60 cell proliferation while combining with different concentrations of DDP. So Apigenin may have chemotherapy-sensitization effect on hl-60; Low concentrations of apigenin can also reduce the resistance of hl-60 cells to chemotherapy-induced apoptosis, which may be related to the down-regulation of NF-κB and BCL-2. (NF-KB is a kind of protein complex that controls DNA transcription, the production of cytokines and cell survival; BCL-2 is encoded in the body through the BCL2 gene, it is the original member of the BCL-2 regulatory proteins family that can regulate cell death )
Apigenin can reduce liver injury induced by ischemia-reperfusion through antagonizing lipid peroxidation and scavenging free radicals.
Apigenin can reduce liver injury caused by oxidative stress due to its potent antioxidant and anti-inflammatory activities.
Pharmacological experiments have proved that apigenin has an apparent protective effect on alcohol-induced liver/hepatocyte injury, and its primary mechanism is related to the inhibition of CYP2E1 expression in the liver/hepatocyte.
Apigenin inhibits osteoblastogenesis, osteoclastogenesis, and also prevents bone loss.
Apigenin protects bone tissue by reducing bone loss in the body.
Some studies related to the MC3T3-E1, an osteoblast precursor cell line derived from Mus musculus (mouse) calvaria, found that apigenin can inhibit the TNF-α, IFN-γ, and then induced the secretion of several cytokines that promote osteoclast formation.
Apigenin also inhibited the differentiation of 3T3-L1 adipose precursor cells into adipocytes strongly, therefore inhibiting the differentiation attendant inhibition adipocyte differentiation-induced IL-6, MCP-1, lectin product.
Apigenin inhibits the differentiation of osteoclasts from RAW264.7 cell lines and then inhibits the formation of multinucleated osteoclasts. It can also induce osteoclast apoptosis and inhibit bone resorption.
Anti-inflammatory and anti-oxidant activity
Apigenin restrains the inflammation process, increases the IL-10 levels and normalizes the oxidative stress parameters
Apigenin inhibits pro-inflammatory cytokines and induces the anti-inflammatory cytokine production.
Some literature suggests that apigenin alleviates tissue inflammation induced by oxidative stress in tissues by modulating various oxidative stress markers, interleukins, blood enzyme markers, and expression of several other related enzymes.
Regulation of endocrine
Apigenin can regulate blood sugar, treat thyroid insufficiency and control lipid peroxidation.It was found that apigenin could increase the levels of insulin and thyroxine in diabetic animals, and decrease the concentration of blood sugar and the activity of glucose-6-phosphorylase (G-6-Pase).
Apigenin reversed the effects of increased serum cholesterol, increased liver lipid peroxidation (LPO) and decreased activities of antioxidants such as catalase (CAT) and superoxide dismutase (SOD) in alloxan-induced animals.
In animals with regular blood sugar, apigenin can also reduce serum cholesterol and liver lipid peroxidation, and increase the activity of antioxidants in cells.
Pharmacological properties of apigenin
Apigenin has been attached great importance in recent years, as a beneficial health promoter on account of its lower intrinsic toxicity and its health effects on regular versus cancer cells, compared with other structurally related flavonoids. There is a bulk of research evidence that has shown apigenin has great therapeutic potential for many diseases
-Inhibit the growth of cancer cells.
-Lower blood pressure
-Protects the cardiovascular system
-Help sleep, calm nerves, eliminate irritability
-Inhibit platelet aggregation.
-Medicine field, Health care field
More information of TRB
|U.S.FDA,CEP,KOSHER HALAL GMP ISO Certificates|
|Nearly 20 years,export 40 countries and regions,more than 2000 batches produced by TRB have no any quality problems,unique purification process,impurity and purity control meet USP,EP and CP|
|Comprehensive Quality System|
|▲Quality Assurance System||
|▲ Document control||
|▲ Validation System||
|▲ Training System||
|▲ Internal Audit Protocol||
|▲ Suppler Audit System||
|▲ Equipment Facilities System||
|▲ Material Control System||
|▲ Production Control System||
|▲ Packaging Labeling System||
|▲ Laboratory Control System||
|▲ Verification Validation System||
|▲ Regulatory Affairs System||
|Control Whole Sources and Processes|
|Strictly controlled all raw material,accessories and packaging materials.Preferred raw materials and accessories and packaging materials supplier with U.S. DMF number.
Several raw material suppliers as supply assurance.
|Strong Cooperative Institutions to support|
|Institute of botany/Institution of microbiology/Academy of Science and Technology/University|
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We emphasize progress and introduce new solutions into the market each year for Original Factory Grape Seed Extract And Breast Cancer - 2019 New Style Top Chamomile Extract Apigenin Powder Cas No 520-36-5 Apigenin 98% – Tong Rui Bio, The product will supply to all over the world, such as: Iraq, Kenya, Buenos Aires, We take measure at any price to attain essentially the most up-to-date gear and procedures. The packing of nominated brand is our a further distinguishing feature. The solutions to assure years of trouble-free service has attracted a great deal customers. The goods are obtainable in improved designs and richer variety, they're produced scientifically of purely raw supplies. It accessible in a variety of designs and specifications for the selection. The newest forms are much far better than the previous one and they're extremely popular with several clients.
By Julia from Mecca - 2015.02.04 14:13
A good manufacturers, we have cooperated twice, good quality and good service attitude.
By Eileen from Washington - 2015.06.18 17:25