Product name: Phosphatidylcholine PC
Synonyms: 1,2-diacyl-sn-glycero-3-phosphocholine, PC
Appearance/color: Light yellow or yellow powder, oil or waxy solid
Package: 1kg/bag, 25kg/drum
Liquid / or waxy solid: about 60%
Powder / granule: 10% – 98%
Popular specs 20%, 50%, 98%
What is Phosphatidylcholine?
Phosphatidylcholine consists of a choline “head” and glycerol phospholipids. The tail of glycerol phospholipids can be a variety of fatty acids. Usually, one tail is saturated fatty acid, the other is an unsaturated fatty acid. But some of them are both unsaturated fatty acids. For example, animal lung phosphatidylcholine has a higher proportion of dipalmitoyl phosphatidylcholine.
Phosphatidylcholine is the main component of biofilms. The source is very simple and comprehensive. You can get phosphatidylcholine from almost any food in your life, not just egg yolk or soybean. It is also lecithin in animal fat. You can find phosphatidylcholine in the tissues of plants and animals. Of course, commercial production of phosphatidylcholine is a purified product with a higher content and a more direct effect.
Phosphatidylcholine is a lipophilic hydrophilic substance; lower alcohol soluble in C1 to C4, insoluble in acetone and water.
Although PCs are traditionally used to support brain health, they can also support liver function and control cholesterol levels.
Choline can cross the blood-brain barrier very easily through the unsaturated-promoting diffusion system, and these plasma changes can produce similar changes in brain choline levels.
Due to the insufficient conversion of the choline transformation process, not fully saturated by the choline substrate, the choline content in the plasma is increased, which promotes the formation of acetylcholine and phosphorylcholine and the release of acetylcholine. If the content of other precursors of phosphatidylcholine is increased, the process of conversion of choline to phosphatidylcholine and the increase in the content of peas are increased. The level of synaptic membranes in the brain increases. Choline is metabolized to betaine in the liver, which is a major pathway for the regeneration of methionine and S-adenosylmethionine to provide a methyl group.
Most of the liver metabolism occurs in the cell membrane that occupies 33,000 square meters of the human body.
There are more than 20 years of clinical trials shown that PC protects the liver from most of the toxic effects that damage cell membranes, such as alcoholism, drugs, pollutants, viruses and other toxic effects.
Another surfactant of PC is the main component of cell membrane and lung, which transports between cell membrane through phosphatidylcholine transfer protein (PCTP). It also plays a role in membrane-mediated cell signal transduction and PCTP activation of other enzymes.
There is a confusing point here. Lecithin is not phosphatidylcholine. Phosphatidylcholine is an important component of lecithin.
Benefits of phosphatidylcholine
- Protect liver from harming
- Improving Cognitive Function
- Preventing side effects of drugs
- Anti-aging magic effect added to cosmetics
- Lipid decomposition
- Coping with ulcerative colitis
According to a large number of animal experiments, PC supplementation can increase acetylcholine (neurotransmitter in the brain), which is an important measure to improve memory. Further studies are underway to observe the effects of PC and other nutrients on memory improvement in dementia mice. It is known that PC and other nutrients have certain positive effects and effective effects, but more tests are needed. More in-depth, in 2017, there were related studies on phosphatidylcholine levels and Alzheimer’s disease.
Liver is an important organ in human body, and some activities in daily life can cause a huge burden on the liver, which is common in fatty liver and cirrhosis.
A high-fat diet can have a negative impact on the liver. Of course, the liver can also be damaged by alcohol poisoning, drugs, pollutants, viruses, and other toxic effects, and repair is extremely difficult. In the past 20 years of clinical trials, the discovery of phosphatidylcholine did not play a vital role in the life-saving process. It can be said that the effect is quite unsatisfactory, but as sildenafil was originally designed to make a heart treatment drug, other effects were found in parts of the trial plan. Through careful analysis, we can discover the protective effect of PC on the liver according to the permeability of phosphatidylcholine and its protective effect on the cell membrane. Since it can’t be repaired, it can be protected in advance, which is also a major role of phosphatidylcholine.
Although phosphatidylcholine is used as a nutritional supplement for oral intake, it does not interfere with its various properties. According to its special physical and biological properties, it can easily penetrate the skin and increase the permeability of other products. Therefore, many manufacturers are very willing to use phosphatidylcholine in their external skin care creams to create smooth and moist skins. Phosphatidylcholine also showed excellent results in the treatment of acne, with a 70% reduction in weathering after 28 days.
Phosphatidylcholine is a vital biological molecule that can be found in every cell of the human body. Some scientists have experimented with mice that have been genetically altered to produce oxidative damage and accelerate aging to study the effects of phosphatidylcholine on aging, cognitive improvement and memory enhancement in Alzheimer’s patients. Of course, some scientists believe that supplementation of phosphatidylcholine to treat Alzheimer’s disease has not been sufficiently evidenced. But the pace of creating a world without Alzheimer cannot stop. Of course, we can not rule out the possibility that phosphatidylcholine has a role, but we need more and larger experiments to prove its specific role.
Side effects of phosphatidylcholine
Mainly reflected in the medical aspect, food-grade PC-containing products can be taken according to the instructions; when used in medicine, should strictly follow the instructions of doctors and drug manufacturers for drug use. In order to avoid these risks of side effects, starting with the lowest possible dose, the maximum dose is gradually achieved.
Oral PC may lead to excessive sweating. Taking more than 30 grams per day may lead to diarrhea, nausea, or vomit.
Injecting PC directly into fat tumors may lead to severe inflammation or fibrosis. It may also lead to pain, burning, itch, blood stasis, edema, and skin redness
PC supplements can be used in capsule and liquid form without a prescription. They are considered safe when used for a short period of time as directed. Injection of PC must be managed by health professionals.
- Neuroprotection: Phosphatidylcholine (PC) is a major component of brain cell membranes. And neurons use some of this choline to synthesize acetylcholine (ACh). Supplementing with PC restores the PC that is needed for brain cell membrane integrity. While providing neurons with the ACh needed for memory and learning.
- Neurotransmitters: Phosphatidylcholine increases concentrations of choline and acetylcholine in the brain. Improving memory and cognition.
- Neurogenesis: Phosphatidylcholine helps restore damaged brain cells. Making them more fluid and permeable allows the proper flow of chemical messengers and nutrients into and out of the cell. And improving overall cell function and efficiency. Resulting in better cognition, learning, memory, and mood.