Polydatin Powder 98% Product Description
Product Overview
Polydatin, also known as Piceid, is a natural stilbene glucoside derived from the rhizomes of Polygonum cuspidatum Sieb. et Zucc. (commonly known as Reynoutria japonica or Huzhang). It is a highly purified compound with a molecular formula of C₂₀H₂₂O₈ and a molecular weight of 390.40. The product is standardized to ≥98% purity, as confirmed by HPLC analysis .
Physical and Chemical Properties
- Appearance: White to off-white powder
- CAS Number: 27208-80-6
- Molecular Formula: C₂₀H₂₂O₈
- Molecular Weight: 390.40
- Solubility:
- DMSO: ≥50 mg/mL
- Ethanol: ≈30 mg/mL
- Water: ≈0.25 mg/mL (in PBS, pH 7.2)
- Storage Conditions:
- Powder: Store at 2–8°C for up to 2 years
- Stock Solution (DMSO): Freeze at -20°C for 1 month; avoid repeated freezing and thawing
- Working Solution: Use immediately after dilution
Biological Activity
Polydatin is a potent antioxidant and exhibits a wide range of biological activities, including:
- Antioxidant and Anti-Inflammatory Effects:
- Scavenges DPPH radicals and inhibits copper-induced lipid peroxidation .
- Reduces oxidative stress and NF-κB activation, modulating inflammatory responses .
- Cardioprotective Effects:
- Protects against myocardial ischemia/reperfusion injury by promoting autophagic flux and reducing apoptosis .
- Enhances NO production via cNOS, improving cardiac function .
- Neuroprotective Effects:
- Reduces mitochondrial membrane potential and reactive oxygen species (ROS) production in neuronal cells .
- Ameliorates blood-brain barrier permeability and protects against neurodegenerative damage .
- Hepatoprotective and Hypolipemic Effects:
- Exhibits anti-inflammatory and antioxidant properties that protect liver cells and reduce lipid levels .
- Anti-Cancer and Anti-Arthritis Effects:
- Inhibits the proliferation of Caco-2 colon cancer cells and induces cell cycle arrest at the S phase .
- Promotes autophagy via the AMPK/mTOR signaling pathway, protecting against articular cartilage degeneration .
Applications
Polydatin is widely used in research and development for its diverse biological activities. It is suitable for:
- Pharmacological Research: As a lead compound for drug development due to its antioxidant, anti-inflammatory, and cardioprotective properties.
- Cosmetic and Skin Health: Improves skin barrier function, reduces inflammation, and alleviates symptoms of atopic dermatitis .
- Dietary Supplements: Supports women’s health by reducing pain associated with endometriosis and dysmenorrhea when combined with palmitoylethanolamide (PEA) .
- Digestive Health: Reduces abdominal pain in patients with irritable bowel syndrome (IBS) when used in conjunction with PEA .
Safety and Handling
- Safety: Polydatin is considered safe and well-tolerated for both oral and topical use. It is not classified as hazardous under GHS standards .
- Handling:
- Avoid direct contact with skin or inhalation.
- Use appropriate personal protective equipment (PPE) during handling.
- Store in a sealed container away from light and air.
References and Citations
- Teguo, P.W., Fauconneau, B., Defieux, G., et al. (1998). Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from Vitis vinifera cell cultures. Journal of Natural Products, 61(5), 655–676.
- Ming, D., Songyan, L., Yawen, C., et al. (2017). trans-Polydatin protects the mouse heart against ischemia/reperfusion injury via…
- Zhengcong Ye, Jian Lin, Chun He, Pengzheng Yu, Guoping Cao, Qinrong Shen, Canfeng Wang. (2024). Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood–brain barrier permeability for its neuroprotective effect in pMCAO rat brain.
Conclusion
Polydatin (98% purity) is a versatile and valuable compound with a wide range of biological activities. Its antioxidant, anti-inflammatory, and cardioprotective properties make it a promising candidate for pharmaceutical and nutraceutical applications. With proper storage and handling, it is an ideal choice for researchers and developers in the fields of health sciences and biotechnology.
