Product Name:S-Acetyl L-Glutathione powder
Other Name:S-acetyl glutathione (SAG); Acetyl Glutathione; Acetyl L-Glutathione; S-Acetyl-L-Glutathione;SAG
CAS No:3054-47-5
Colour: White to off-white powder with characteristic odor and taste
Specification:≥98% HPLC
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Product Description: S-Acetyl L-Glutathione Powder
Product Overview
S-Acetyl L-Glutathione (S-A-GSH) is a highly bioavailable and stable form of glutathione, a powerful antioxidant naturally produced in the human body. It is a derivative of reduced glutathione (GSH) and is specifically designed to enhance cellular glutathione levels while maintaining stability during digestion. S-A-GSH is widely used in health and wellness products, research, and clinical applications due to its unique properties and effectiveness in supporting antioxidant defense, detoxification, and immune function .
Key Features
- Chemical Structure: S-Acetyl L-Glutathione is a tripeptide composed of glutamic acid, cysteine, and glycine, with an acetyl group attached to the sulfur atom of cysteine. This structural modification significantly enhances its stability and absorption in the gastrointestinal tract .
- Purity and Specifications: The product is available in high purity (≥98%) and is typically supplied as a white crystalline powder. It has a molecular formula of C₁₂H₁₉N₃O₇S and a molecular weight of 349.36. The CAS number is 3054-47-5 .
- Solubility: S-Acetyl L-Glutathione is soluble in water and can be easily dissolved in aqueous solutions. It is also compatible with various organic solvents, making it suitable for a wide range of applications .
- Storage Conditions: The powder should be stored at -20°C to maintain its stability and potency. When dissolved in a solvent, it should be stored at -80°C to prevent degradation .
Mechanism of Action
S-Acetyl L-Glutathione is absorbed intact through the gut lining and is then metabolized into reduced glutathione (GSH) inside the cell. This process is facilitated by the acetyl group, which prevents oxidation during digestion and ensures that the full glutathione molecule is available for cellular use . Once inside the cell, the acetyl group is cleaved, releasing GSH, which plays a critical role in neutralizing free radicals, supporting detoxification, and maintaining cellular health .
Health Benefits
- Antioxidant Support: S-Acetyl L-Glutathione is a potent antioxidant that helps protect cells from oxidative stress caused by free radicals. It supports the body’s natural defense mechanisms and enhances the activity of other antioxidants, such as vitamin C and E .
- Detoxification: Glutathione is a key component of the body’s detoxification system, particularly in the liver. S-Acetyl L-Glutathione supports hepatic detoxification pathways and helps the body eliminate toxins, heavy metals, and environmental pollutants .
- Immune Function: S-Acetyl L-Glutathione enhances immune function by modulating the activity of immune cells, including lymphocytes, macrophages, and T-cells. It also supports the production of cytokines and improves the body’s ability to fight infections and diseases .
- Anti-Aging and Skin Health: As a powerful antioxidant, S-Acetyl L-Glutathione helps reduce oxidative stress, which is a major contributor to aging and skin damage. It may also support skin whitening and improve the appearance of the skin by reducing melanin production .
- Mitochondrial Protection: S-Acetyl L-Glutathione helps protect mitochondrial function by reducing reactive oxygen species (ROS) and improving mitochondrial integrity. This is essential for maintaining cellular energy production and overall health .
Applications
- Health Supplements: S-Acetyl L-Glutathione is commonly used as a dietary supplement to support antioxidant status, enhance immune function, and promote overall well-being. It is often combined with other nutrients, such as N-acetyl-cysteine (NAC) and vitamin B6, to enhance its effectiveness .
- Research and Development: The compound is widely used in research for its role in antioxidant stress response, redox signaling, and cellular detoxification. It is also used in the study of diseases related to oxidative stress, such as neurodegenerative disorders, diabetes, and cancer .
- Cosmetic and Skincare: S-Acetyl L-Glutathione is used in cosmetic formulations for its skin-lightening and antioxidant properties. It helps reduce pigmentation, improve skin texture, and protect against UV-induced damage .
Safety and Precautions
- Research Use Only: While S-Acetyl L-Glutathione is generally considered safe for use in health supplements and research, it is important to note that it is still under investigation for its long-term effects on human health. It is recommended to consult a healthcare professional before using it for therapeutic purposes .
- Storage and Handling: The product should be stored at the recommended temperature to maintain its stability and potency. When handling the powder, it is advisable to wear appropriate personal protective equipment (PPE), such as gloves and a mask, to avoid exposure to the powder .
- No Medical Claims: S-Acetyl L-Glutathione is not intended to diagnose, treat, cure, or prevent any disease. It is a supportive supplement and should not be used as a substitute for medical treatment .
Conclusion
S-Acetyl L-Glutathione is a highly bioavailable and stable form of glutathione that offers a range of health benefits, including antioxidant support, detoxification, immune enhancement, and anti-aging effects. Its unique structure and properties make it a valuable supplement for maintaining cellular health and overall well-being. As a product for research and health applications, it is essential to follow proper storage and handling guidelines to ensure its effectiveness and safety
