Lebitso la Sehlahisoa:Agomelatine

Lebitso le Leng:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide

Nomoro ea CAS:138112-76-2

Litlhaloso: 99.0%

'Mala: Phofo e tšoeu e nang le monko le tatso e ikhethang

Boemo ba GMO:GMO Mahala

Ho paka: ka meqomo ea fiber ea 25kgs

Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla

Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso

AgomelatineTlhaloso ea Sehlahisoa

1. Tlhaloso ea Sehlahisoa
Agomelatine ke novel antidepressant e nang le mekhoa e 'meli e ikhethang ea ketso: e sebetsa e le melatonin receptor agonist (MT1/MT2) le mohanyetsi oa 5-HT2C receptor**. Lebitso la eona la lik'hemik'hale keN-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, ka foromo ea molek'hule C₁₅H₁₇NO₂ le nomoro ea CAS138112-76-2. E fumaneha ka mokhoa oa phofo kapa oa letlapa (25 mg letlapa ka leng), e hloekile haholo (≥98% ka HPLC) 'me e qhibiliha ka har'a metsoako ea tlhaho e kang DMSO le ethanol.

2. Lipontšo
Agomelatine e bontšoa bakeng sa phekolo ea boloetse bo tebileng ba ho tepella maikutlo (MDD) ho batho ba baholo, haholo-holo ho bakuli ba sa mamelleng li-antidepressants tse tloaelehileng kapa ba nang le ho tšoenyeha ho bakoang ke ho sithabela maikutlong kapa ho robala. Liteko tsa bongaka li bonts'a katleho ea ho ntlafatsa matšoao a tepeletseng maikutlo, taolo ea morethetho oa circadian, le ts'ebetso ea mots'eare.

3. Mokhoa oa ho Etsa

• MT1/MT2 Agonism: E khutlisetsa morethetho oa circadian ka ho etsisa melatonin, ho ntlafatsa boleng ba boroko le ho falimeha ha motšehare**.
• 5-HT2C Antagonism: E eketsa tokollo ea dopamine le norepinephrine ka har'a prefrontal cortex, e fokotsa matšoao a khatello ea maikutlo.
  Ketso ena e habeli e khetholla Agomelatine ho SSRIs/SNRIs, e fana ka boemo bo botle ba mamello.

4. Tekanyo le Tsamaiso

• Tekanyetso e khothalletsoang: 25-50 mg hang ka letsatsi pele ho robala **.
• Pharmacokinetics: ho kenngoa ka potlako (sehlohlolong sa plasma nakong ea lihora tse 2), metabolized ka CYP1A2, 'me e ntšoa ka renal **.

5. Katleho ea Bongaka

• Bokaholimo ho Taolo ea Circadian: Agomelatine e ntlafatsa haholo latency ea boroko le katleho ha e bapisoa le sertraline, e nang le litlamorao tse bonoang pele ho Beke ea 1 **.
• Melemo ea nako e telele: E boloka tšoarelo ho MDD ho feta selemo sa 1, ka litekanyetso tse fokolang tsa ho khutlela morao le ho khaotsa ho fokolang ka lebaka la liphello tse mpe **.
• Matšoenyeho le Mosebetsi: E fokotsa matšoao a ho tšoenyeha le ho ntlafatsa mosebetsi, boiketlo ba sechaba, le ts'ebetso ea lelapa**.

6. Polokeho le Mamello

• Litla-morao tse Tloaelehileng: Ho opeloa ke hlooho, nasopharyngitis, le tšitiso e fokolang ea mala **.
• Boemo ba Polokeho: Ha ho na boima ba 'mele, ho se sebetse hantle ka thobalano, kapa matšoao a ho tlohela, a ikamahanyang le khetho ea eona ea ho amohela**.
• Tlhokomeliso ea Tikoloho: E khethiloe e le chefo ea metsing (WGK 3); qoba ho pepesehela tikoloho ka kotloloho**.

7. Ho boloka le ho Tšoara

• Polokelo: Boloka ho 2–8°C (phofo) kapa mocheso oa kamore (matlapa a ka har’a sephutheloana sa pele)**.
• Botsitso: E tsitsitse ka lilemo tse ≥2 ha e sirelelitsoe leseli le mongobo **.

8. Boemo ba Taolo

• E amohetsoe ho EU, Australia, le limmarakeng tse ling tlasa mabitso a marang-rang joalo kaValdoxan®**.
• E thathamisitsoe ho WHO International Nonproprietary Names (INN) le FDA Preferred Term databases**.

9. Likopo tsa Lipatlisiso
Agomelatine e boetse e sebelisoa lithutong tsa preclinical bakeng sa neuroprotection, tau protein phosphorylation, le pontšo ea calcium ho li-neurone. Litekanyetso tsa litšupiso (mohlala, litšila, metabolites) li teng bakeng sa nts'etsopele ea meriana le taolo ea boleng.

Mantsoe a sehlooho :Agmelatine, MT1/MT2 agonist, mohanyetsi oa 5-HT2C, bothata bo boholo ba ho tepella maikutlo, morethetho oa circadian, Valdoxan, katleho ea ho imeloa kelellong, serotonin receptor, melatonin analog.