Covid-19, kapa e tsejoang hape e le vaerase ea 2019-nCoV kapa SARS-CoV-2, ke ea lelapa la Coronavirus. Jwaloka ha SARS-CoV-2 e le ya genus Coronavirus e amana haholo le MERS-CoV le SARS-CoV - tseo le tsona ho tlalehilweng hore di baka matshwao a matla a nyumonia mafung a seoa a fetileng. Sebopeho sa lefutso sa 2019-nCoV se khethollotsoe mme sa phatlalatsoa. [I] [ii] Liprotheine tse kholo tsa vaerase ena le tse neng li khethiloe pejana ho SARS-CoV kapa MERS-CoV li bontša ho tšoana ho hoholo lipakeng tsa tsona.
Boreleli ba mofuta ona oa vaerase bo bolela hore ho na le lipelaelo tse ngata tse potapotileng boits'oaro ba eona, ka hona ho mathoasong haholo ho tseba hore na limela tsa limela kapa metsoako e ka kenya letsoho sechabeng e le li-prophylactic agents kapa e le lintho tse loketseng litlhare tsa anti-coronavirus khahlano le Covid -19. Leha ho le joalo, ka lebaka la ho tšoana ho hoholo ha Covid-19 le livaerase tse tlalehiloeng pejana tsa SARS-CoV le MERS-CoV, patlisiso e fetileng e phatlalalitsoeng ka metsoako ea litlama, e netefalitsoeng hore e na le litlamorao tsa anti-coronavirus, e kanna ea ba tataiso ea bohlokoa ea ho fumana anti-coronavirus limela tsa litlama, tse ka sebetsang khahlano le vaerase ea SARS-CoV-2.
Kamora ho qhoma ha SARS-CoV, e tlalehiloeng ka lekhetlo la pele mathoasong a 2003 [iii], boramahlale ba ntse ba leka ka matla ho sebelisa metsoako e mengata ea likokoana-hloko khahlanong le SARS-CoV. Sena se ne se lebisitse ho sehlopha sa litsebi China ho lekola litlatsetso tse fetang 200 tsa litlama tsa Machaena bakeng sa mesebetsi ea li-antiviral khahlano le mofuta ona oa coronavirus.
Har'a tsena, lihlahisoa tse 'ne li bontšitse litlamorao tse itekanetseng ho isa ho tse matla khahlano le SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (fern), Artemisia annua (lengana le monate) le Lindera aggregate (setho se nkhang hamonate sa kamehla se lulang se le setala sa lelapa la laurel ). Litholoana tsa likokoana-hloko tsa tsena li ne li ipapisitse le tekanyetso 'me li fapana ho tloha maemong a tlase a tlhotla ho ea holimo, a fapana bakeng sa monko o mong le o mong oa litlama. Haholo-holo Lycoris radiata e bonts'itse tšebetso e matla ka ho fetesisa ea vaerase khahlano le khatello ea vaerase. [Iv]
Sephetho sena se ne se lumellana le sa lihlopha tse ling tse peli tsa lipatlisiso, tse fanang ka maikutlo a hore setho se mafolofolo se fumanehang metso ea Licorice, Glycyrrhizin, ho netefalitsoe hore se na le tšebetso e khahlanong le SARS-CoV ka ho thibela ho ipheta ha eona. [V] [vi] Ho se seng Ho ithuta, Glycyrrhizin hape e bonts'itse ts'ebetso ea li-antiviral ha e lekoa bakeng sa litlamorao tsa eona tsa in vitro ho likokoana-hloko tse 10 tse fapaneng tsa SARS coronavirus. Baicalin - e leng karolo ea semela sa Scuttelaria baicalensis (Skullcap) - le eona e lekiloe phuputsong ena tlasa maemo a ts'oanang mme e boetse e bonts'itse khato ea antiviral khahlano le coronavirus ea SARS. [Vii] Baicalin le eona e bontšitsoe e thibela phetiso ea HIV -1 virus in vitro in lithuto tse fetileng. [Viii] [ix] Leha ho le joalo ho lokela ho hlokomeloa hore liphuputso tsa vitro li kanna tsa se tsamaisane le ts'ebetso ea bongaka ea vivo. Lebaka ke hobane tekanyetso ea molomo ea mahlahana ana bathong e kanna ea se fihlelle mohopolo oa serum ea mali o ts'oanang le o lekiloeng ka vitro.
Lycorine e boetse e bonts'itse tšebetso e matla ea lithibela-mafu khahlanong le SARS-CoV.3 Litlaleho tse 'maloa tse fetileng li bontša hore Lycorine e bonahala e na le mesebetsi e pharalletseng ea lithibela-mafu mme ho tlalehiloe hore e bonts'itse tšebetso e thibelang vaerase ea Herpes Simplex (mofuta oa I) [x] le Poliomyelitis. le kokoana-hloko hape. [xi]
"Litlama tse ling tse tlalehiloeng li bonts'itse tšebetso ea likokoana-hloko khahlano le SARS-CoV ke Lonicera japonica (Honeysuckle ea Japane) le semela sa Eucalyptus se tsebahalang haholo, le Panax ginseng (motso) ka karolo ea eona e sebetsang ea Ginsenoside-Rb1." [Xii]
Bopaki bo tsoang liphuputsong tse boletsoeng kaholimo le liphuputso tse ling tse 'maloa tsa lefats'e li tlaleha hore litlama tse ngata tsa litlama li bonts'itse mesebetsi e thibelang likokoana-hloko khahlano le li-coronaviruses [xiii] [xiv] mme mochini oa bona o ka sehloohong oa ts'ebetso o bonahala e le ka thibelo ea phetiso ea vaerase. [Xv] China e sebelisitse haholo litlama tsa setso tsa Machaena tsa kalafo bakeng sa kalafo ea SARS maemong a mangata. [xvi] Leha ho le joalo ha ho na bopaki bo matla mabapi le katleho ea kliniki ea tsena bakeng sa bakuli ba nang le tšoaetso ea Covid-19.
Na lintho tse joalo tsa litlama e ka ba likhetho bakeng sa nts'etsopele ea meriana e ncha ea likokoana-hloko bakeng sa thibelo kapa kalafo ea SARS?
TLHOKOMELISO: Sengoloa sena se ngotsoe ka sepheo sa ho fana ka tlhaiso-leseling feela mme ha se ea rereloa ho nkela likeletso tsa litsebi tsa bongaka kalafo, tlhahlobo ea kalafo kapa kalafo. Haeba u nahana hore u ka ba le matšoao a amanang le a Covid-19 kapa lefu lefe kapa lefe, letsetsa ngaka hanghang.
[i] Zhou, P., Yang, X., Wang, X. et al., 2020. Ho qhoma ha pneumonia ho amanang le coronavirus e ncha ea semelo sa 'mankhane. Tlhaho 579, 270-273 (2020). https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC le Garry, RF, 2020. Tšimoloho ea projeke ea SARS-CoV-2. Tlhaho ea Meriana, maq. 1-3.
[iii] Lenane-nako la likarabo tsa CDC SARS. E fumaneha ho https://www.cdc.gov/about/history/sars/timeline.htm. E fihletsoe
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG le Li, RS, 2005. Ho khetholla metsoako ea tlhaho e nang le mesebetsi ea li-antiviral khahlano le coronavirus e amanang le SARS. Patlisiso ea antiviral, 67 (1), maq. 18-23.
[v] Cinatl, J., Morgenstem, B. le Bauer, G., 2003. Glycyrrhizin, karolo e sebetsang ea metso ea licorice le ho pheta-pheta ha coronovirus e amanang le SARS. Lancet, 361 (9374), maq. 2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW le Cinatl, J., 2005. Ts'ebetso ea Antiviral ea Lihlahisoa tsa Glycyrrhizic Acid khahlanong le SARS− Coronavirus. Tlaleho ea chemistry ea bongaka, 48 (4), maq. 1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW le Guan, Y., 2004. Ho ba le ts'oaetso ea in vitro ea likliniki tse 10 tsa SARS coronavirus ho metsoako e khethiloeng ea likokoana-hloko. Tlaleho ea Clinical Virology, 31 (1), maq. 69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. le Tokunaga, T., 1998. Baicalin, inhibitor ea Tlhahiso ea HIV-1 in vitro. Patlisiso ea likokoana-hloko, 37 (2), maq. 311-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW le Wang, JM, 2000. Flavonoid baicalin e thibela tšoaetso ea HIV-1 boemong ba ho kenella ha vaerase. Lipuisano tsa lipatlisiso tsa biochemical le biophysical, 276 (2), maq. 534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. le Kobayashi, S., 1989. Phello ea li-alkaloids tse ikhethileng ho Amaryllidaceae ho vaerase ea herpes simplex. Lipatlisiso ka virology, 140, maq. 115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. le Alderweireldt, F., 1982. Limela likokoana-hloko tse thibelang likokoana-hloko. III. Ho aroloa ha li-alkaloid ho tsoa ho Clivia miniata Regel (Amaryl-lidaceae). Journal ea Lihlahisoa tsa Tlhaho, 45 (5), maq. 564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. le Liang, FS, 2004 Limolek'hule tse nyane tse shebileng haholo lefu le matla la ho hema coronavirus ea motho. Ts'ebetso ea Sekolo sa Naha sa Saense, 101 (27), maq. 10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS le Hou, CC, 2007. Tse khethehileng semela terpenoids le lignoids li na le mesebetsi e matla ea li-antiviral khahlano le lefu le matla la ho hema coronavirus. Litaba tsa k'hemistri ea bongaka, 50 (17), maq. 4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW le Towers, GHN, 1995. Ho hlahloba likokoana-hloko tsa limela tsa bongaka tsa Brithani tsa Columbian. Tlaleho ea Ethnopharmacology, 49 (2), maq. 101-110.
[xv] Jassim, SAA le Naji, MA, 2003. Novel agents antiviral: pono ya semela se phekolang. Journal ea microbiology e sebelisitsoeng, 95 (3), maq. 412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. le Liu, JP, 2020. Na moriana oa China o ka sebelisoa bakeng sa thibelo ea lefu la vaerase ea corona 2019 (COVID -19)? Tlhahlobo ea khale ea khale, bopaki ba lipatlisiso le mananeo a hajoale a thibelo. Tlaleho ea China ea Bongaka bo Kopantseng, maq. 1-8.
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Nako ea poso: Apr-18-2020