Pyrroloquinoline Quinone disodium Salt(PQQ)

Pyrroloquinoline quinone (PQQ), e tsejoang hape e le Methoxy Platinum, ke cofactor ea redox.E fumaneha mobung, kiwifruit, lijong le lebeseng la motho.Ha re bua ka kotloloho, lentsoe "pyrroloquinoline quinone" ha le bonolo, kahoo batho ba bangata ba khetha ho sebelisa khutsufatso ea PQQ.Koranta ea mahlale ea Nature e phatlalalitse pampiri ea Kasahara le Kato ka 2003, e neng e nka hore PQQ ke vithamine e ncha.Leha ho le joalo, kamora lipatlisiso tse ling mabapi le pyrroloquinoline quinone, bafuputsi ba ile ba etsa qeto ea hore leha e na le thepa e kang ea vithamine, ke limatlafatsi tse amanang feela.PQQ e ka sebelisoa e le co-factor kapa mothetsi oa enzymatic ts'ebetsong ea redox.PQQ e na le phello e khethehileng ea antioxidant ka lebaka la ho nka karolo ho redox.

Lebitso la Sehlahisoa:Pyrroloquinoline Quinone disodium Letsoai

Nomoro ea CAS: 122628-50-6/ 72909-34-3

Boima ba 'mele: 374.17/ 330.21

Foromo ea molek'hule: C14H4N2Na2O8/ C14H6N2O8

Tlhaloso: PQQ Disodium Letsoai 99% Asiti ea PQQ 99%

Ponahalo: Bokhubelu ba lamunu ho ea ho Reddish Brown Powder e Ntle.

Kopo: E sebelisoa haholo bakeng sa tlatsetso ea lijo le li-nutraceuticals.

Polokelo: E bolokiloe sebakeng se iketlileng le se omileng, tloha letsatsing le tobileng.

Pyrroloquinoline Quinonemehloli ea lijo

PQQ ka tlhaho e teng lijong tse ngata tsa meroho, litholoana le meroho (trace), mme maemo a phahameng a PQQ a ka bonoa lihlahisoa tsa soya tse lomositsoeng, joalo ka kiwifruit, lychee, linaoa tse tala, tofu, peō ea rapese, mosetareta, tee e tala (camellia) , pepere e tala, spinach, joalo-joalo.

G.Haug o fumane hore e ne e le cofactor ea boraro ea redox ho libaktheria ka mor'a nicotinamide le flavin (le hoja a ne a nahana hore ke naphthoquinone).Anthony le Zatman le bona ba fumane li-cofactors tse sa tsejoeng tsa redox ho ethanol dehydrogenase.Ka 1979, Salisbury le basebetsi-'moho le eena hammoho le Duine le basebetsi-'moho le bona ba ile ba ntša setsi sena sa pseudo ho methanol dehydrogenase ea dinoflagellate 'me ba tsebahatsa sebopeho sa eona sa limolek'hule.Adachi le basebetsi mmoho le yena ba fumane hore Acetobacter le yona e na le PQQ.

Mokhoa oa ts'ebetso eaPyrroloquinoline Quinone

Pyrroloquinoline quinone (PQQ) ke molek'hule e nyane ea quinone, e nang le phello ea redox, e ka fokotsa oxidant (antioxidant);ebe e khutlisetsoa sebopehong se sebetsang ka glutathione.E bonahala e tsitsitse hobane e ka feta likete-kete tsa potoloho pele e fokotseha, 'me e ncha hobane e amana le sebopeho sa protheine ea lisele (li-antioxidants tse ling, li-carotenoids tse kang beta-carotene le astaxanthin, li fumaneha libakeng tse itseng tsa lisele, moo ba bapalang likarolo tse ngata tsa antioxidant ka tekano).Ka lebaka la ho ba haufi, PQQ e bonahala e bapala karolo e haufi le liprotheine tse joalo ka carotenoids ho membrane ea lisele.

Mesebetsi ena ea redox e ka fetola mesebetsi ea protheine le litsela tsa ho fetisetsa lipontšo.Leha ho na le lithuto tse ngata tse ts'episang tsa in vitro (mefuta ea kantle ea ho phela), liphetho tse ling tse ts'episang tsa tlatsetso ea PQQ li amana haholo le ho fetola litsela tse ling tsa phetisetso ea mats'oao kapa melemo ea bona ho mitochondria.(Hlahisa ho feta le ho ntlafatsa katleho).

Ke coenzyme ka baktheria (kahoo bakeng sa baktheria, e tšoana le livithamine tsa B), empa ha e bonahale e fetela ho batho.Kaha sena ha se sebetse ho batho, sehlooho sa 2003 ho Nature, koranta ea saense, se pheha khang ea hore khopolo ea hore PQ ke motsoako oa vithamine e siiloe ke nako ’me e nkoa e le “ntho e kang ea vithamine.”

Mohlomong se hlokomelehang haholo ke phello ea PQQ ho mitochondria, e fanang ka matla (ATP) le ho laola metabolism ea lisele.Bafuputsi ba hlokometse haholo phello ea PPQ ho mitochondria mme ba fumane hore PQQ e ka eketsa palo ea mitochondria esita le ho ntlafatsa katleho ea mitochondria.Lena ke lebaka la bohlokoa le etsang hore PPQ e be molemo hakana.Li-enzyme tse nang le PQQ li tsejoa e le glucose dehydrogenase, protheine ea quinoa e sebelisoang e le sensor ea tsoekere.

Melemo ea Pyrroloquinoline Quinone

Ho ba le mitochondria ka botlalo ho bohlokoa haholo bakeng sa bophelo bo botle hoo o ka bang le melemo e mengata ha o ntse o nka ppq.Mona ke tse ling tsa melemo e hlokomelehang ka pyrroloquinoline quinone.

Ho eketsa Matla a Lisele

Hobane mitochondria e hlahisa matla bakeng sa lisele, 'me PQQ e thusa mitochondria ho sebetsa ka katleho, matla a lisele a eketseha ka kakaretso;ona ke mochine oa Pyrroloquinoline Quinone mitochondrial.Matla a cellular a sa sebelisoeng a fetisetsoa likarolong tse ling tsa 'mele.Haeba 'mele oa hau o haelloa ke matla letsatsi lohle, kapa o ikutloa o khathetse kapa o otsela, joale matla a eketsehileng a PPQ a bohlokoa ho uena.Phuputso e 'ngoe e fumane hore kamora ho nka PQQ, batho ba nang le mathata a matla a tlalehiloeng ba ne ba e-na le mokhathala o fokolang haholo.Haeba u batla ho hong ho eketsa matla a hau, PQQ e ka u thusa ka seo.

Ho thibela ho fokotseha ha kelello

Ka tsoelo-pele ea saense, bo-rasaense ba fumane hore methapo ea ho hōla ha methapo (NGF) e ka hōla le ho hlaphoheloa.Ka nako e ts'oanang, PQQ e bontšitsoe hore e na le phello e ntle ho NGF le ho eketsa kholo ea methapo ka makhetlo a 40.NGF ke ea bohlokoa bakeng sa ho thehoa le ho boloka li-neurone tse ncha, 'me e ka tsosolosa li-neuron tse senyehileng tse ka thibelang ts'ebetso ea kelello.Li-neurons ke lisele tse fetisang boitsebiso, kahoo boko ba rona bo khona ho buisana pakeng tsa bona le likarolo tse ling tsa 'mele.Ho ntlafatsa boleng le bongata ba li-neurone ho ka ntlafatsa temoho.Ka hona, PQQ e na le ntlafatso ea nakoana.

Ho tšehetsa bophelo bo botle ba pelo

Pyrroloquinoline quinine e fana ka ts'ehetso ea antioxidant le mitochondrial.Boithuto bo bonts'itse hore PQQ le CoQ10 ka bobeli li ts'ehetsa ts'ebetso ea myocardial le ts'ebeliso e nepahetseng ea oksijene ea cellular.Pyrroloquinoline quinone e thibela khatello ea oxidative ka ho nchafatsoa ha eona.

Tšebeliso e 'ngoe:

Ntle le melemo e meraro ea mantlha e thathamisitsoeng ka holimo, PQQ e fana ka melemo e meng e sa tsejoeng haholo.PQQ e ka bapala karolo ea ho fokotsa ho ruruha ha 'mele, ho ntlafatsa boroko ba hau le ho ntlafatsa ho ba le bana, empa lipatlisiso tse ling lia hlokahala ho fihlela liqeto tse hlakileng.Ha lipatlisiso li ntse li tsoela pele, melemo e mengata ea ho nka PQQ e ka fumanoa.

Tekanyetso ea Pyrroloquinoline Quinone

Hajoale, ha ho mmuso kapa WHO e boletseng litekanyetso tsa pyrroloquinoline quinone.Leha ho le joalo, batho ba bang le mekhatlo e entse liteko tse ngata tsa likokoana-hloko le liteko tsa batho ka tekanyo e nepahetseng ea phofo ea pyrroloquinoline quinone.Ka ho shebella le ho bapisa tšebetso ea 'mele ea barupeluoa, ho fihleloa qeto ea hore tekanyetso e nepahetseng ea PQQ ke 20 mg-50 mg.Kamehla fetisetsa ngaka ea hau haeba ho na le lipotso tse emetseng.Joalo ka letsoai la biopqq pyrroloquinoline quinone disodium.

Litla-morao tsa PQQ

Ho tloha ka 2009, li-supplement tsa lijo tse nang le PQQ Na 2 li rekisitsoe United States kamora tsebiso e hlophisitsoeng ke Tsamaiso ea Lijo le Lithethefatsi (FDA), mme ha ho litlamorao tse mpe tse tlalehiloeng.Haeba u batla ho kenyelletsa li-supplement tsa pyrroloquinoline quinone lijong tsa hau, ho bohlokoa ho hopola ntho e le 'ngoe.Kaha ha e hloke PQQ e ngata haholo ho hlahisa phello, litekanyetso tse ngata li bolokoa maemong a fokolang.Ka hona, batho ba bangata ha ba na ho tšoenyeha ka litla-morao tsa Pyrroloquinoline Quinone.(Ke uena ea rekileng tlatsetso ea pyrroloquinoline quinone PQQ ho eonammaraka)