Lebitso la Sehlahisoa: Pyrroloquinoline Quinone disodium Letsoai
Nomoro ea CAS: 122628-50-6/ 72909-34-3
Boima ba 'mele: 374.17/ 330.21
Foromo ea molek'hule: C14H4N2Na2O8/ C14H6N2O8
Tlhaloso: PQQ Disodium Letsoai 99% Asiti ea PQQ 99%
Ponahalo: Bokhubelu ba lamunu ho ea ho Reddish Brown Powder e Ntle.
Kopo: E sebelisoa haholo bakeng sa tlatsetso ea lijo le li-nutraceuticals.
Polokelo: E bolokiloe sebakeng se iketlileng le se omileng, tloha letsatsing le tobileng.
Mehloli ea lijo ea Pyrroloquinoline Quinone
PQQ ka tlhaho e teng lijong tse ngata tsa meroho, litholoana le meroho (trace), mme maemo a phahameng a PQQ a ka bonoa lihlahisoa tsa soya tse lomositsoeng, joalo ka kiwifruit, lychee, linaoa tse tala, tofu, peō ea rapese, mosetareta, tee e tala (camellia), pepere e tala, spinach, jj.
G.Haug o fumane hore e ne e le cofactor ea boraro ea redox ho libaktheria ka mor'a nicotinamide le flavin (le hoja a ne a nahana hore ke naphthoquinone). Anthony le Zatman le bona ba fumane li-cofactors tse sa tsejoeng tsa redox ho ethanol dehydrogenase. Ka 1979, Salisbury le basebetsi-'moho le eena hammoho le Duine le basebetsi-'moho le bona ba ile ba ntša setsi sena sa pseudo ho methanol dehydrogenase ea dinoflagellate 'me ba tsebahatsa sebopeho sa eona sa limolek'hule. Adachi le basebetsi mmoho le yena ba fumane hore Acetobacter le yona e na le PQQ.
Mokhoa oa ts'ebetso oa Pyrroloquinoline Quinone
Pyrroloquinoline quinone (PQQ) ke molek'hule e nyane ea quinone, e nang le phello ea redox, e ka fokotsa oxidant (antioxidant); ebe e khutlisetsoa sebopehong se sebetsang ka glutathione. E bonahala e tsitsitse hobane e ka feta likete-kete tsa potoloho pele e fokotseha, 'me e ncha hobane e amana le sebopeho sa protheine ea lisele (li-antioxidants tse ling, li-carotenoids tse ka sehloohong tse kang beta-carotene le astaxanthin, li fumaneha libakeng tse itseng tsa lisele, moo li bapalang likarolo tse ngata tsa antioxidant ka ho lekana). Ka lebaka la ho ba haufi, PQQ e bonahala e bapala karolo e haufi le liprotheine tse joalo ka carotenoids ho membrane ea lisele.
Mesebetsi ena ea redox e ka fetola mesebetsi ea protheine le litsela tsa ho fetisetsa lipontšo. Leha ho na le lithuto tse ngata tse ts'episang tsa in vitro (mefuta ea kantle ea ho phela), liphetho tse ling tse ts'episang tsa tlatsetso ea PQQ li amana haholo le ho fetola litsela tse ling tsa phetisetso ea mats'oao kapa melemo ea bona ho mitochondria. (Hlahisa ho feta le ho ntlafatsa katleho).
Ke coenzyme ka baktheria (kahoo bakeng sa baktheria, e tšoana le livithamine tsa B), empa ha e bonahale e fetela ho batho. Kaha sena ha se sebetse ho batho, sehlooho sa 2003 ho Nature, koranta ea saense, se pheha khang ea hore khopolo ea hore PQ ke motsoako oa vithamine e siiloe ke nako ’me e nkoa e le “ntho e kang ea vithamine.”
Mohlomong se hlokomelehang haholo ke phello ea PQQ ho mitochondria, e fanang ka matla (ATP) le ho laola metabolism ea lisele. Bafuputsi ba hlokometse haholo phello ea PPQ ho mitochondria mme ba fumane hore PQQ e ka eketsa palo ea mitochondria esita le ho ntlafatsa katleho ea mitochondria. Lena ke lebaka la bohlokoa le etsang hore PPQ e be molemo hakana. Li-enzyme tse nang le PQQ li tsejoa e le glucose dehydrogenase, protheine ea quinoa e sebelisoang e le sensor ea tsoekere.
Melemo ea Pyrroloquinoline Quinone
Ho ba le mitochondria ka botlalo ho bohlokoa haholo bakeng sa bophelo bo botle hoo o ka bang le melemo e mengata ha o ntse o nka ppq. Mona ke tse ling tsa melemo e hlokomelehang ka pyrroloquinoline quinone.
Ho eketsa Matla a Lisele
Hobane mitochondria e hlahisa matla bakeng sa lisele, 'me PQQ e thusa mitochondria ho sebetsa ka katleho, matla a lisele a eketseha ka kakaretso; ona ke mochine oa Pyrroloquinoline Quinone mitochondrial. Matla a cellular a sa sebelisoeng a fetisetsoa likarolong tse ling tsa 'mele. Haeba 'mele oa hau o haelloa ke matla letsatsi lohle, kapa o ikutloa o khathetse kapa o otsela, joale matla a eketsehileng a PPQ a bohlokoa ho uena. Phuputso e 'ngoe e fumane hore kamora ho nka PQQ, batho ba nang le mathata a matla a tlalehiloeng ba ne ba e-na le mokhathala o fokolang haholo. Haeba u batla ho hong ho eketsa matla a hau, PQQ e ka u thusa ka seo.
Ho thibela ho fokotseha ha kelello
Ka tsoelo-pele ea saense, bo-rasaense ba fumane hore methapo ea ho hōla ha methapo (NGF) e ka hōla le ho hlaphoheloa. Ka nako e ts'oanang, PQQ e bontšitsoe hore e na le phello e ntle ho NGF le ho eketsa kholo ea methapo ka makhetlo a 40. NGF ke ea bohlokoa bakeng sa ho thehoa le ho boloka li-neurone tse ncha, 'me e ka tsosolosa li-neuron tse senyehileng tse ka thibelang ts'ebetso ea kelello. Li-neurons ke lisele tse fetisang boitsebiso, kahoo boko ba rona bo khona ho buisana pakeng tsa bona le likarolo tse ling tsa 'mele. Ho ntlafatsa boleng le bongata ba li-neurone ho ka ntlafatsa temoho. Ka hona, PQQ e na le ntlafatso ea nakoana.
Ho tšehetsa bophelo bo botle ba pelo
Pyrroloquinoline quinine e fana ka ts'ehetso ea antioxidant le mitochondrial. Boithuto bo bonts'itse hore PQQ le CoQ10 ka bobeli li ts'ehetsa ts'ebetso ea myocardial le ts'ebeliso e nepahetseng ea oksijene ea cellular. Pyrroloquinoline quinone e thibela khatello ea oxidative ka ho nchafatsoa ha eona.
Pyrroloquinoline Quinone disodium Salt (PQQ): Melemo, Tšebeliso, le Tataiso ea Polokeho
Selelekela
Pyrroloquinoline Quinone Disodium Salt (PQQ) ke mofuta o tsitsitseng, o qhibilihang metsing oa PQQ, cofactor ea redox e nang le thepa e matla ea antioxidant. E fumaneha ka tlhaho ka bongata lijong tse kang kiwifruit, parsley, le pepere e tala, PQQ e sebelisoa haholo ho li-supplement tsa lijo bakeng sa melemo ea eona ea lisele le methapo. Ho feta 80% ea li-supplement tsa khoebo li sebelisa mofuta oa letsoai oa disodium ka lebaka la botsitso le bioavailability e ntlafalitsoeng.
Likarolo tsa Bohlokoa
- Sebopeho sa Lik'hemik'hale: C₁₄H₄N₂Na₂O₈ ( Boima ba 'mele: 374.17)
- Ponahalo: Bofubetsoana bo bofubelu-bosootho ho isa bofubedung bo bokgubedu ba lamunu phofo e ntle
- Bohloeki: ≥98% (HPLC e netefalitsoe)
- Sollubility: 3 g/L ka metsing ho 25°C
- Shelf Life: E tsitsitse likhoeli tse 36 ha e bolokiloe ka lijaneng tse tiisitsoeng, hole le khanya le mongobo.
Melemo ea Bophelo bo Botle
- E matlafatsa Matla a Liselefounu: PQQ e kenya tšebetsong biogenesis ea mitochondrial, e ntlafatsa tlhahiso ea ATP le matla a cellular.
- E tšehetsa Mosebetsi oa Kelello: Lithuto tsa bongaka li bonts'a mohopolo o ntlafetseng, ho tenyetseha ha kelello, le lebelo la tsamaiso, haholo-holo ho batho ba baholo ba banyenyane (lilemo tse 20-40).
- Antioxidant & Neuroprotective Effects: Ha e nke lehlakore li-radicals tsa mahala, e fokotsa khatello ea kelello ea oxidative, 'me e khothalletsa motsoako oa ho hōla ha methapo ea kutlo (NGF).
- Cardiovascular Health: E sireletsa khahlanong le tšenyo ea oxidative methapong ea mali le ho tšehetsa mosebetsi oa pelo.
- Matla a Anti-Botsofali: E ntlafatsa bophelo bo botle ba letlalo ka ho fokotsa tšenyo ea oxidative le ho ntlafatsa collagen synthesis.
Lisebelisoa le litekanyetso
- Mefuta e Tloaelehileng: Ho khothalletsoa ho ja ka letsatsi le letsatsi: 10-20 mg bakeng sa bophelo bo botle ka kakaretso; litekanyetso tse phahameng (ho fihla ho 40 mg) li ka sebelisoa tlas'a tlhokomelo ea bongaka.
- Li-capsules / Softgels: 10-20 mg (hangata e kopantsoe le CoQ10 bakeng sa liphello tsa synergistic) .
- Li-powders/Liquids: 7-20 mg ka ho sebeletsa, e loketse metsoako ea lino kapa lijo tse sebetsang.
- Formulation Flexibility:
- PQQ Letsoai la Disodium: E qhibilihang ka metsi, e loketse li-capsules, matlapa le lino tse entsoeng ka phofo.
- PQQ Acid: E qhibilihang ka oli, e loketse li-softgels le lino tse entsoeng ka emulsified.
Boleng & Polokeho
- Teko ea Mokha oa Boraro: E netefalitsoe bakeng sa bohloeki (≥98%) le lihlahisoa tse tlaase tsa tšepe e boima (loto ≤0.5 ppm, arsenic ≤1 ppm) .
- Boemo ba Polokeho: Ka kakaretso e amoheloa e le e bolokehileng (GRAS) ka litekanyetso tse khothaletsoang. Ikopanye le mofani oa tlhokomelo ea bophelo haeba e le moimana, ea anyesang kapa ea noang meriana .
- Polokelo: Boloka sebakeng se phodileng, se omileng (2–8°C) ho boloka botsitso.
Lintlha Tse ka Sehloohong
- Mehloli ea Tlhaho vs. Tlatsetso: Le ha PQQ e le teng lijong, tlatsetso ea hlokahala ho fihlela litekanyetso tse sebetsang hantle tsa bongaka.
- Boemo ba Taolo: E amohetsoe e le motsoako oa lijo tse ncha ho EU le China, ka lipatlisiso tse tsoelang pele ho holisa lits'ebetso.
