Product Name:Tangeretin powder
Other Name:Citrus aurantium extract, Citrus peel Extract, citrus polymethoxyflavones extract, citrus bioflavonoid extract
Botanic Source:Tangerines; Deuterophoma traceiphila; Fortunella japonica
Latin Name:Syringa reticulata (Blume) Hara var. amurensis (Rupr.) Pringle
Assay:10%, 98%,99% Tangeretin
CAS No:481-53-8
Colour: White powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Product Name: Tangeretin
CAS Number: 481-53-8
Formal Name: 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Synonyms: NSC 53909, NSC 618905, Ponkanetin, Tangeritin
Molecular Formula: C₂₀H₂₀O₇
Molecular Weight: 372.4
Purity: ≥98%
Appearance: White powder
Solubility:
- Soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF)
- Sparingly soluble in aqueous buffers
- For maximum solubility in aqueous buffers, tangeretin should first be dissolved in DMF and then diluted with the aqueous buffer of choice
- Solubility in DMF-PBS (pH 7.2) is approximately 0.15 mg/ml
Storage Conditions:
- Store at -20°C for up to 3 years
- For aqueous solutions, store at -80°C for up to 2 days
Stability:
- Stable for at least 4 years under proper storage conditions
Description:
Tangeretin is a polymethoxylated flavone isolated from the peels of citrus fruits, particularly tangerines and mandarins. It is a natural compound with a wide range of biological activities, including anti-inflammatory, antioxidant, and anti-cancer properties. Tangeretin has been shown to inhibit signaling pathways such as ERK, p38 MAPK, JNK, and Akt, which are involved in cancer cell proliferation and survival .
Biological Activities and Applications:
- Anti-Cancer Effects:
- Tangeretin inhibits the growth of breast cancer cells (e.g., T47D) and lung cancer cells (e.g., A549) by reducing ERK phosphorylation and blocking p38 MAPK, JNK, and Akt activation .
- It sensitizes cisplatin-resistant human ovarian cancer cells by downregulating the PI3K/Akt signaling pathway, enhancing apoptosis and cell cycle arrest .
- Tangeretin also induces G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells .
- Anti-Inflammatory and Neuroprotective Effects:
- Tangeretin modulates NF-κB signaling, reducing inflammation and oxidative stress in various disease models, including kidney injury and neuroinflammation .
- It exhibits anti-neuroinflammatory effects by inhibiting the activation of microglial cells in lipopolysaccharide-stimulated cultures .
- Tangeretin is a potent inhibitor of Notch-1, showing neuroprotective and anti-inflammatory effects in several disease models .
- Other Applications:
- Tangeretin has been shown to protect renal tubular epithelial cells against cisplatin-induced toxicity by reducing oxidative stress and inflammation .
- It may also have potential in diabetes management due to its antioxidant and anti-inflammatory properties .
Usage and Safety:
- This product is intended for research use only and is not suitable for clinical diagnosis or treatment.
- Always follow the recommended storage and handling procedures to maintain product integrity and safety.
Supplier Information:
- Brand: Cayman Chemical
- Product ID: 10009911
- Batch-Specific Data: Each batch is accompanied by a certificate of analysis (COA) providing detailed analytical results.
References:
- Cayman Chemical Product Information
- Aragon et al. (2009) on tangeretin’s anti-cancer effects
- Hirano et al. (1995) on tangeretin’s anti-leukemic activity
- Lee et al. (2016) on tangeretin’s anti-inflammatory and antioxidant mechanisms in microglia
Conclusion:
Tangeretin is a versatile and potent natural compound with a wide range of biological activities, making it a valuable tool in cancer research, inflammation studies, and neuroprotection. Its high purity, stability, and solubility in various solvents make it suitable for a wide range of experimental applications
