Amayeza e-Herbal kunye ne-coronavirus strains: amava okuqala asifundisa ntoni?

I-Covid-19, okanye enye eyaziwa njenge-2019-nCoV okanye i-SARS-CoV-2 intsholongwane, yeyosapho lweCoronavirus. Njengokuba i-SARS-CoV-2 ingeye-genus Coronavirus inxulumene ngokusondeleyo neMERS-CoV kunye ne-SARS-CoV - ekwanikwe ingxelo yokuba ibangela iimpawu ezinzima zenyumoniya kwindyikitya yokufa yangaphambili. Ubume bemfuza ye-2019-nCoV ibonakalisiwe kwaye yapapashwa. [I] [ii] Ezona proteni ziphambili kule ntsholongwane kunye nezo zichongwe ngaphambili kwi-SARS-CoV okanye kwi-MERS-CoV zibonisa ukufana okuphezulu phakathi kwazo.

Ukutsha kolu hlobo lwentsholongwane kuthetha ukuba kukho ukungaqiniseki okuninzi okujikeleze isimilo sayo, ke ngoko kusekwangoko kakhulu ukufumanisa ukuba ingaba izityalo zemifuno okanye iikhompawundi zinokuba negalelo eluntwini njengeearhente zokuthintela okanye njengezinto ezifanelekileyo kumachiza e-coronavirus ngokuchasene neCovid -19. Nangona kunjalo, ngenxa yokufana okuphezulu kwe-Covid-19 kunye neentsholongwane ze-SARS-CoV kunye ne-MERS-CoV, uphando lwangaphambili olushicilelweyo kwimichiza yemifuno, ebonakalise ukuba ineziphumo zokulwa ne-coronavirus, inokuba sisikhokelo esibalulekileyo ekufumaneni i-anti-coronavirus izityalo zemifuno, ezinokusebenza ngokuchasene nentsholongwane ye-SARS-CoV-2.

Emva kokuqhawuka kwe-SARS-CoV, eyaxelwa okokuqala ebutsheni buka-2003 [iii], izazinzulu bezizama ngamandla ukuxhaphaza iikhompawundi ze-antiviral ngokuchasene ne-SARS-CoV. Oku bekukhokelele iqela leengcali eTshayina ukuba lihlolisise ngaphezulu kwama-200 amayeza amayeza amaTshayina kwimisebenzi ye-antiviral ngokuchasene nale ngxaki ye-coronavirus.

Phakathi kwezi, izicatshulwa ezine zibonise ukumodareyitha kwiziphumo ezinamandla zokuthintela ngokuchasene ne-SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (fern), Artemisia annua (Umhlonyane oswiti) kunye neLindera aggregate ). Iziphumo zokulwa neentsholongwane kwezi zixhomekeke kwidosi kwaye zisusela koxinzelelo olusezantsi lwesicatshulwa ukuya phezulu, zahluka kwisiphumo ngasinye semveliso. Ingakumbi i-Lycoris radiata ibonakalise eyona nto inamandla ukulwa intsholongwane. [Iv]

Esi siphumo besingqinelana namanye amaqela amabini ophando, athe acebisa ukuba indawo esebenzayo efumaneka kwiingcambu zeLicorice, iGlycyrrhizin, ibonakalisiwe ukuba inento elwa ne-SARS-CoV ngokunqanda ukuphindaphindeka kwayo. [V] [vi] Kwenye Isifundo, iGlycyrrhizin ikwabonakalise umsebenzi we-antiviral xa kuvavanywa iziphumo zayo ze-vitro antiviral kwi-10 ezahlukeneyo zeklinikhi ezizimeleyo ze-SARS coronavirus. IBaicalin - indawo yesityalo iScuttelaria baicalensis (Skullcap) - nayo iye yavavanywa kolu phononongo phantsi kwale meko inye kwaye ikwabonakalise inyathelo le-antiviral ngokuchasene ne-SARS coronavirus. [Vii] IBaicalin ikwabonakalisiwe inqanda ukuphindaphindeka kwe-HIV -1 Intsholongwane kwi-vitro kwizifundo zangaphambili. [Viii] [ix] Nangona kunjalo kufanele kuqatshelwe ukuba iziphumo ze-vitro zinokungahambelani nokusebenza kweeklinikhi ngokukuko. Kungenxa yokuba idosi yomlomo yezi arhente ebantwini ayinakufezekisa uxinzelelo lwe-serum yegazi efanayo naleyo yavavanywa kwi-vitro.

I-Lycorine ikwabonakalise isenzo esinamandla sokulwa intsholongwane nxamnye ne-SARS-CoV.3 Iingxelo ezininzi ezidlulileyo zibonisa ukuba i-Lycorine ibonakala inemisebenzi ebanzi ye-antiviral kwaye kuye kwabikwa ukuba ibonakalisile isenzo sokuthintela intsholongwane ye-Herpes Simplex (uhlobo I) [x] kunye ne-Poliomyelitis Intsholongwane nayo. [xi]

“Amanye amayeza ekuxelwe ukuba abonise ukungasebenzi kwe-SARS-CoV yi-Lonicera japonica (iJapan Honeysuckle) kunye nesityalo esaziwa njenge-Eucalyptus, kunye ne-Panax ginseng (ingcambu) ngecandelo layo elisebenzayo iGinsenoside-Rb1.” [Xii]

Ubungqina obuvela kwezi zifundo zikhankanywe apha ngasentla kunye nolunye uphononongo olwenziwe kwihlabathi liphela lubonisa ukuba uninzi lwamayeza e-herbal abonakalise imisebenzi ye-antiviral ngokuchasene ne-coronaviruses [xiii] [xiv] kwaye eyona ndlela yokusebenza inyanzeliswayo kubonakala ngathi kuthintelo lokuphindaphindeka kwentsholongwane. [Xv] China Usebenzise kakhulu amayeza esintu amaTshayina ekunyangeni i-SARS ngokukuko kwiimeko ezininzi. [xvi] Nangona kunjalo akukabikho bungqina bubambekayo ngokusebenza kweklinikhi kwezi zigulana ezine-Covid-19 ezosulelekileyo.

Ngaba izicatshulwa zemifuno zinokuba ngabafundi abanokubakho kuphuhliso lwamayeza amatsha antiviral othintelo okanye unyango lweSARS?

ISIQINISEKISO: Eli nqaku libhalelwe ulwazi kuphela kwaye ayenzelwanga ukufaka iingcebiso zonyango, isifo okanye unyango. Ukuba ucinga ukuba unokuba neempawu ezinxulumene nezo zeCovid-19 okanye nasiphi na esinye isifo, tsalela ugqirha wakho kwangoko.

[i] Zhou, P., Yang, X., Wang, X. et al., 2020. Ukuqhambuka kwenyumoniya okunxulunyaniswa ne-coronavirus entsha yemvelaphi yelulwane enokwenzeka. Uhlobo lwe-579, 270-273 (2020). https://doi.org/10.1038/s41586-020-2012-7

[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC kunye noGarry, RF, 2020. Imvelaphi ephambili ye-SARS-CoV-2. Amayeza endalo, iphe. 1-3.

[iii] CDC SARS Ixesha lokuphendula. Iyafumaneka kwi-https: //www.cdc.gov/about/history/sars/timeline.htm. Ifunyenwe

[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG kunye noLi, RS, 2005. Ukuchongwa kweekhompawundi zendalo kunye nemisebenzi yentsholongwane ngokuchasene ne-coronavirus ehambelana ne-SARS. Uphando nge-Antiviral, 67 (1), iphe. 18-23.

[v] ICinatl, J., Morgenstem, B. kunye neBauer, G., 2003. IGlycyrrhizin, icandelo elisebenzayo leengcambu zelayisensi kunye nokuphindaphinda i-coronovirus ehambelana neSARS. ILancet, 361 (9374), iphepha 2045-2046.

[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW kunye neCinatl, J., 2005. SARS− Coronavirus. Ijenali yamachiza amayeza, i-48 (4), iphe. 1256-1259.

[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW kunye neGuan, Y., Ngo-2004. In vitro susceptibility of 10 clinical isolates of SARS coronavirus to compit antiviral compounds. Ijenali yonyango lwezonyango, 31 (1), iphe. 69-75.

[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. kunye noTokunaga, T., 1998. IBaicalin, isithintelo se Imveliso ye-HIV-1 kwi-vitro. Uphando nge-Antiviral, 37 (2), iphe. 131-140.

[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW kunye noWang, JM, 2000. I-flavonoid baicalin inqanda usulelo lwe-HIV-1 kwinqanaba lokungena kwintsholongwane. Unxibelelwano lwezinto eziphilayo kunye nophando, 276 (2), iphe. 534-538.

[x] URenard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. kunye noKobayashi, S., 1989. Iziphumo zeealkaloids ezizimeleyo kwiAmaryllidaceae kwintsholongwane ye-herpes simplex. Uphando kwi-virology, i-140, iphe. 115-128.

[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. no Alderweireldt, F., 1982. Tyala iiarhente zokulwa intsholongwane. III. Ukubekwa ecaleni kwee-alkaloids ezivela kwiClivia miniata Regel (Amaryl-lidaceae). Ijenali yeeMveliso zeNdalo, i-45 (5), iphe. 564-573.

[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. noLiang, FS, 2004 Iimolekyuli ezincinci zijolise ngqo kwisifo sokuphefumla esiqatha. Iinkqubo zeSizwe seSizwe seSayensi, i-101 (27), iphe. 10012-10017.

[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS kunye neHou, CC, 2007. isityalo se-terpenoids kunye ne-lignoids zinezinto ezinamandla zokulwa neentsholongwane ngokuchasene nesifo sokuphefumla esiqatha. Ijenali yamachiza amayeza, i-50 (17), iphe. 4087-4095.

[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW kunye neTowers, GHN, 1995. Ukuhlolwa kweAntiviral kwezityalo zamayeza zaseBritane zaseColombia. Ijenali ye-Ethnopharmacology, 49 (2), iphe. 101-110.

[xv] Jassim, SAA kunye Naji, MA, 2003. Inoveli ye-arhente ye-antiviral: umbono wezityalo zonyango. Ijenali ye-microbiology esetyenzisiweyo, i-95 (3), iphe. 412-427.

[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. kunye noLiu, JP, 2020. Ngaba amayeza amaTshayina angasetyenziselwa ukuthintela isifo se-corona virus 2019 (COVID -19)? Uphengululo lwembali zakudala, ubungqina bophando kunye neenkqubo zangoku zokuthintela. Ijenali yaseTshayina yoNyango oluDibeneyo, iphe. 1-8.

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Ixesha Post: Apr-18-2020