Igama lomkhiqizo:I-Piperlongumineimpushana
Elinye Igama: I-Piplatin, i-Piperlongumine extract, i-Piplartine, i-5,6-Dihydro-1-[(2E) -1-oxo-3- (3,4,5-trimethoxyphenyl) -2-propen-1-yl] -2(1H) -pyridinone,PPLGM, i-pippali powder, i-Piper Longum extract
Inombolo ye-CAS: 20069-09-4
Umthombo Wezitshalo:Piper Longum Linn
Isivivinyo: 98%min
Isampuli yamahhala :Iyatholakala
Ukubukeka: I-crystalline powder emhlophe
Izinzuzo: Anti-cancer, anti-ukuguga, senolytic
Impilo yeshelufu: iminyaka emi-2
I-Piperlongumine Powder| Ukuhlanzeka Okuphezulu (98%+) | I-CAS 20069-09-4 | Okokusebenzisa Ucwaningo
Uhlolojikelele Lomkhiqizo
I-Piperlongumine (Piplatine), i-alkaloid esebenzayo etholakala ku-I-Piper longumplant, iyinhlanganisela yemvelo enezindawo ezikhethiwe zokulwa nomdlavuza. Ingenisa ngempumelelo izinhlobo ze-oxygen esebenzayo (ROS) kumaseli omdlavuza, okuholela ku-apoptosis ngaphandle kokulimaza amaseli ajwayelekile, iyenze ibe umuntu othembisayo ocwaningweni lwe-oncology.
Izici Eziyinhloko
- Ubumsulwa: ≥98% (HPLC iqinisekisiwe)
- Inombolo ye-CAS: 20069-09-4
- I-Molecular Formula: C₁₇H₁₉NO₅
- Isisindo samangqamuzana: 317.34 g/mol
- Ukubukeka: Impushana emhlophe ukuya kokumhlophe
- Ukuncibilika: Ayincibiliki emanzini; I-soluble ku-DMSO (≥10.45 mg/mL), i-ethanol, nezinye izincibilikisi eziphilayo
- Isitoreji: Gcina ku -20°C endaweni eyomile, emnyama. Izinzile iminyaka engu-3 .
Indlela Yokwenza
I-Piperlongumine iqondisa ngokukhethekile amaseli omdlavuza ngezindlela eziningi:
- I-ROS Induction: Inyusa amazinga e-ROS e-intracellular, ivuse ingcindezi ye-oxidative kanye ne-apoptosis kumaseli omdlavuza.
- I-GSTP1 Inhibition: Icindezela i-glutathione S-transferase Pi 1 (GSTP1), iphazamisa ibhalansi ye-redox kumaseli ayingozi.
- I-STAT3 Pathway Suppression: Ivimbela ukusayinda kwe-STAT3, inciphisa ukwanda kwesimila kanye nokusinda.
- Ukuvinjelwa kwe-Thioredoxin Reductase (TrxR1): Iqondise ngokungenakuhlehliswa izinsalela ze-selenocysteine, ithuthukisa i-chemosensitivity.
Izicelo Zocwaningo
- I-Cancer Therapeutics:
- Idala i-apoptosis yebele, i-prostate, nemigqa yeseli ye-myeloma (IC₅₀: 1–5 μM) .
- Isebenzisana nama-ejenti e-chemotherapy (isb, i-doxorubicin, i-cisplatin) ukuze inqobe ukumelana nezidakamizwa .
- Izifundo Zendlela Yesiginali:
- Imodela i-NF-κB, i-MAPK, kanye ne-JAK/STAT3 izindlela .
- I-Neuroprotection & Ukuguga:
- Isekela impilo ye-neuronal futhi inciphise ingcindezi ye-oxidative kumamodeli ahlobene nobudala .
- Ucwaningo lwenhliziyo nemithambo yegazi:
- Ivimbela i-atherosclerosis ngokucindezela ukwanda kwemisipha ebushelelezi yemithambo.
Imininingwane Yomkhiqizo
| Usayizi Wephakheji | Ifomu | Ubumsulwa |
|---|---|---|
| 10 mg | I-Lyophilized powder | ≥98% |
| 50 mg | I-Lyophilized powder | ≥98% |
| Ama-oda Enqwaba Yangokwezifiso | Itholakala ngesicelo |
Ukuphatha nokuphepha
- Ukumiswa kabusha: Disolve ku-DMSO yeku-vitroizifundo. Ngobange vivoizinhlelo zokusebenza, sebenzisa i-polysorbate 80 noma i-cyclodextrin-based formulations ukuze kuthuthukiswe ukunyibilika.
- Ukuzinza: Izinzile ku-pH 4–7. Gwema ukuchayeka kokukhanya isikhathi eside ngenxa yezingozi zokuwohloka kwezithombe .
- Inothi Lokuphepha: Okokusetshenziswa kocwaningo kuphela. Ayihloselwe izinhlelo zokusebenza zokuxilonga noma zokwelapha .
Kungani Khetha I-Piperlongumine Yethu?
- Isiqinisekiso Sokuhlanzeka Okuphezulu: I-QC Eqinile nge-HPLC kanye nemibhalo ye-MSDS/COA.
- Ukutholakala Kwenqwaba: Ukuhlanganiswa ngokwezifiso kwezidingo zocwaningo olukhulu .
- Ukuthobelana Komhlaba Wonke: Kuhlangabezana nezindinganiso zamazwe ngamazwe zamakhemikhali e-reagent-grade.
Izithenjwa
- Umsebenzi wokulwa nomdlavuza okhethiwe ngokungeniswa kwe-ROS.
- Ukusebenza okuthuthukisiwe kwemithi yokwelapha eyinhlanganisela .
- Amaphrofayili wokuncibilika nokuzinza .
Amagama angukhiye: I-Piperlongumine powder, ucwaningo lwe-anticancer, ukufakwa kwe-ROS, i-STAT3 inhibitor, i-alkaloid ephezulu yokuhlanzeka.
