RU58841

Incazelo emfushane:

I-RU58841 umuthi wokwelapha ukulahleka kwezinwele onciphile, mhlawumbe ngenxa yamandla okuhweba kanye nezizathu zokuzinza kwamakhemikhali kunokusebenza kahle njengoba izifundo zakamuva ze-RU58841 zigxile ezinhlotsheni ezahlukene zamakhemikhali zomuthi futhi ziwuhlanganisa nezinhlayiya ezincane ezahlukene ukuthuthukisa ukulethwa.

I-RU58841 (eyaziwa nangokuthi i-RU-58841) iyinhlanganisela, i-RU58841 incintisana ne-dihydrotestosterone ukugcina amazinga e-DHT ngaphakathi kwebanga elijwayelekile, ngaleyo ndlela ilawula umjikelezo wokukhula kwezinwele. Ivuselela ukuguqulwa kwama-follicle ezinwele amasha abe ama-follicle ezinwele e-anagen ngokungena esigabeni se-anagen. Ukuvumela ama-follicle alimele isikhathi sokushintshela esigabeni sokukhula esijwayelekile kusiza amaseli ukuthi alulame. Iphinde ikhulise ukugeleza kwegazi kuma-follicle alimele futhi iwasize aphinde avuseleleke. Ngakolunye uhlangothi, i-RU58841 (RU-58841) isebenza ngokubopha kuma-receptor e-androgen kuma-follicle ezinwele. Ngakho ama-androgen awanayo ithuba lokubopha nokuqala ukusabela kwe-chain ye-androgenetic alopecia nokuqala inqubo ebizwa ngokuthi i-miniaturization. Kuye kwabonakala ukuthi kuphazamisa lo myalezo wokulahlekelwa izinwele endaweni ukuze ukukhula kwezinwele okuvamile kuqhubeke.

I-RU58841 Ebizwa nangokuthi i-Minoxidil kwakuyisidakamizwa sokuqala esavunyelwa yi-FDA ekwelapheni i-androgenetic alopecia (ukulahlekelwa izinwele). Ngaphambi kwalokho, i-minoxidil yayisetshenziswa njengomuthi we-vasodilator ochazwe njengephilisi lomlomo ukwelapha umfutho wegazi ophakeme, nemiphumela emibi eyayihlanganisa ukukhula kwezinwele nokuguqula impandla yabesilisa. Ngawo-1980, i-UpJohn Corporation yakhipha ikhambi elikhethekile le-minoxidil engu-2%, elibizwa ngokuthi i-Rogaine, lokwelapha i-androgenetic alopecia. Kusukela ngawo-1990, izinhlobo eziningi ezijwayelekile ze-minoxidil sezitholakale ukwelapha ukulahleka kwezinwele ngenkathi ifomu lomlomo lisasetshenziswa ukwelapha umfutho wegazi ophakeme.

I-Minoxidil umuthi we-vasodilator owaziwa ngekhono lawo lokunciphisa noma ukuvimba ukulahleka kwezinwele nokukhuthaza ukukhula kabusha kwezinwele. Itholakala ngaphandle kwekhawunta yokwelapha i-androgenic alopecia, phakathi kwezinye izindlela zokwelapha i-baldness, kodwa izinguquko ezilinganiswayo ziyanyamalala zingakapheli izinyanga ngemuva kokuyeka ukwelashwa. Ukusebenza kwayo kubonakale kakhulu kwabesilisa abasebasha (abaneminyaka engu-18 kuya kwengu-41 ubudala), abancane baba ngcono, nakulabo abane-bald engxenyeni ephakathi (ye-vertex) yesikhumba sekhanda.

Intengo ye-FOB:US 5 - 2000 / KG

Ubuningi be-Order encane:1 kg

Amandla Okunikezela:10000 KG/ngenyanga

Imbobo:I-Shanghai / Beijing

Imigomo Yokukhokha:I-L/C,D/A,D/P,T/T,O/A

Imigomo Yokuthumela:Ngolwandle/Ngendiza/Nge-Courier

I-imeyili:: info@trbextract.com

Sithumelele i-imeyili Landa njenge-PDF

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Igama Lomkhiqizo:RU58841

Elinye Igama:4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,Inombolo ye-CAS:154992-24-2

Imininingwane: 99.0%

Umbala: Impuphu emhlophe enephunga elihlukile kanye nokunambitheka

Isimo se-GMO: Ayinayo i-GMO

Ukupakisha: kuma-drum e-fiber angu-25kgs

Indawo Yokugcina: Gcina isitsha singavulwanga endaweni epholile, eyomile, Gcina kude nokukhanya okunamandla

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqizwa

RU58841: I-Anti-Androgen Yocwaningo Lokulahlekelwa Izinwele Ezingaphandle Kwendawo
I-Non-Steroidal DHT Blocker enesenzo sendawo

Ukubuka Konke Komkhiqizo

I-RU58841 (CAS: 154992-24-2), eyaziwa nangokuthi i-PSK-3841 noma i-HMR-3841, iyinhlanganisela engeyona i-steroidal anti-androgen eyasungulwa ekuqaleni ngawo-1990 ososayensi baseFrance. Njengomphikisi we-androgen receptor oncintisanayo, ibopha kuma-receptor e-follicle ezinwele, ivimbele i-dihydrotestosterone (DHT) ekubangeleni i-androgenetic alopecia (ukulahleka kwezinwele kwephethini) ngaphandle kokushintsha amazinga ama-hormone esistimu.

Izici Eziyinhloko:

Indlela yokusebenza: Incintisana ne-DHT kuma-receptor ekhanda, ivimbela ukwenziwa kwe-follicle ibe yincane.
Isenzo Esitholakala Endaweni: Sisebenza ngaphandle kokunciphisa i-serum DHT noma i-testosterone.
Ukusebenza kahle: Izivivinyo zemitholampilo kuma-primate zibonise ukukhula kabusha kwezinwele okungu-103% uma kuqhathaniswa no-88% nge-finasteride.
Ubumsulwa: ≥99% impuphu emhlophe, encibilikayo kubathwali be-ethanol/propylene glycol.

Isizinda Sesayensi

Izivivinyo Zemitholampilo
- Izivivinyo zeSigaba II sikaProstrakan (2005) zibonise ukulingana/ubukhulu be-RU58841 kune-finasteride ezinyangeni eziyi-6.
- Kuma-stumptail macaques, isixazululo esingu-5% se-RU58841 sisebenze kangcono kune-finasteride yomlomo, ngaphandle kokunciphisa i-DHT.
- Izilingo zabantu zamiswa ngenxa yezizathu ezingacacile (izimali, ukuphepha, noma izinkinga zelungelo lobunikazi).
Iphrofayili Yokuphepha
- Imiphumela Ebikiwe: Ukucasuka kwendawo, i-erythema, kanye nemiphumela engavamile yomzimba (isb., izinguquko zobulili).
- Isexwayiso: Akuvunyelwe yi-FDA; idatha yokuphepha kwabantu yesikhathi eside inqunyelwe.

Iziqondiso Zokusebenzisa

Ukulungiselela:

Hlanganisa i-RU58841 powder engu-30-100mg ne-ethanol engu-70% + 30% ye-propylene glycol (isb., i-ethanol engu-0.7ml + 0.3ml ye-PG ngesisombululo esingu-1ml).

Isicelo:

Hlanza futhi womise isikhumba sekhanda kahle.
Faka isisombululo esingu-1ml nsuku zonke (kungcono ebusuku) ezindaweni ezithintekile.
Gwema ukusebenzisa kanyekanye imikhiqizo enamafutha ukuze uthuthukise ukumuncwa.

Isitoreji:

Gcina impuphu ku--20°C; isixazululo esilungisiwe siqinile izinsuku ezingu-30 ekushiseni kwegumbi.

Izinzuzo Kunezinye Izindlela

Isici	RU58841	I-Finasteride/i-Minoxidil
Ububanzi Besenzo	Kwenziwe endaweni (isikhumba sekhanda kuphela)	Ukunciphisa i-DHT ehlelekile
Umthelela wama-hormone	Akukho ukushintsha kwe-serum DHT/T	Yehlisa i-DHT ngo-70%
Ukuvunyelwa kwe-FDA	Inhlanganisela yocwaningo	I-OTC evunyelwe yi-FDA
Ukufaneleka kobulili	Isebenza kahle kokubili kwabesilisa nabesifazane	Ngokuyinhloko kwabesilisa

Ukuthenga Nokuthobela Imithetho

Isimo Esisemthethweni: Kuhlukaniswe njengekhemikhali yocwaningo; hhayi yokusetshenziswa kwezokwelapha kwabantu/izilwane.
Abahlinzeki: Kutholakala ngabathengisi abakhethekile (isib. i-Anageninc, i-Lyphar Biotech) ngokuthunyelwa kwesifunda.
Isixwayiso: Xhumana nochwepheshe bezempilo ngaphambi kokusebenzisa. Ukuthobela imithetho yendawo kuyimpoqo.