Aha ngwaahịa: Nicotinamide riboside chloride ntụ ntụ
Aha ndị ọzọ: 3- (Aminocarbonyl) -1-PD-ribofuranosyl-pyridinium chloride (1: 1); Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride; NR, vitamin NR;
CAS Mba:23111-00-4
Nyocha: 98% min
Agba: Gbanyụọ ọcha ka ọ bụrụ ntụ ntụ edo edo na-acha odo odo
Ọnọdụ GMO: GMO efu
Mbukota: na 25kgs fiber drum
Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike
Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta
Nicotinamide Riboside Chloride ntụ ntụ: precursor NAD + adịchaghị maka ahụike emelitere na ogologo ndụ
Nchịkọta ngwaahịa
Nicotinamide Riboside Chloride (NR-Cl) bụ ụdị kristal nke Vitamin B3, nke a ghọtara dị ka ihe na-arụ ọrụ nke ọma na Nicotinamide Adenine Dinucleotide (NAD +), coenzyme dị mkpa maka metabolism ike cell, mmezi DNA, na ịka nká. Site na usoro kemịkalụ C11H15N2O5Cl na ịdị arọ molecular 290.70 g/mol, a na-ahazi ya ka ọ bụrụ ≥95% ịdị ọcha (HPLC) ma na-agbaso ụkpụrụ FDA GRAS (A na-amatakarị dị ka Nchekwa).
Uru isi
- Na-akwalite ọkwa NAD+:
NR-Cl na-abawanye NAD + intracellular site na ~ 220%, na-eme ka nicotinamide (NAM) na nicotinic acid (NA) na-eme ka ọ ghara imebi ma ọ bụ gbochie sirtuins. NAD + kwalitere na-akwado ọrụ mitochondrial, mmepụta ume, na ịgbalite protein ndị metụtara ogologo ndụ dị ka SIRT1 na SIRT3. - Mgbochi ịka nká & Nchekwa Neuro:
Ọmụmụ ụlọ ọgwụ na-egosi ọrụ NR-Cl n'ibelata mbelata ọgụgụ isi na ụdị Alzheimer na ịkwalite ịka nká site na ijikwa usoro nrụzi cellular NAD + dabere. - Ahụike Metabolic:
Na-egbochi mmebi metabolic na-ebute oke abụba na-akpata ma na-akwado njikwa ibu site na ịkwalite metabolism oxidative. - Nchekwa & Ịrụ Ọrụ:
- FDA-akwadoro: Ozi atọ GRAS atọ na ule ụlọ ọgwụ mmadụ anọ ebipụtara na-akwado nchekwa na doses ruo 2,000 mg / ụbọchị (atụ aro: 250-300 mg / ụbọchị).
- Enweghị mmetụta dị n'akụkụ: N'adịghị ka NMN (Nicotinamide Mononucleotide), NR-Cl bụ ihe dị ndụ n'ọnụ, kwụsiri ike na capsules, ma na-ezere ihe egwu metụtara ịgba ọgwụ.
Uru ngwaahịa
- Ịdị ọcha kristal: Recrystallized na ihe mgbaze pola (dịka, methanol), NR-Cl na-enye nkwụsi ike dị elu na ịdị ọcha kemịkal ma e jiri ya tụnyere ụdị amorphous.
- Nkwekọrịta zuru ụwa ọnụ: akwadoro n'okpuru ụkpụrụ EU Novel Food Regulations (EU 2017/2470) na CAS No.23111-00-4, n'ịhụ na nrubeisi iwu maka mgbakwunye na nyocha.
- Ngwa dịgasị iche iche: Kwesịrị ekwesị maka mbadamba nkume, capsules, na usoro mmiri mmiri. Dakọtara na DMSO (172 mM) na mmiri (430 mM) maka iji ụlọ nyocha.
NR-Cl vs. NMN: Gịnị kpatara ịhọrọ NR-Cl?
| Njirimara | NR-Cl | NMN |
|---|---|---|
| Nnweta bioailability | Inweta ekwentị ozugbo | Chọrọ ntụgharị gaa na NR |
| Ọnwụnwa ụlọ ọgwụ mmadụ | 4+ bipụtara ọmụmụ | Oke data |
| Profaịlụ nchekwa | FDA GRAS, enweghị mmetụta ọjọọ | Enweghị data nchekwa ogologo oge |
| Mfe nhazi | O siri ike na capsules (300 mg) | Na-ama aka encapsulate |
| Ọnụ-arụmọrụ | Mmụba NAD+ dị elu kwa dose | Obere arụmọrụ |
Ojiji & Nchekwa
- Usoro akwadoro: 250-300 mg / ụbọchị maka mgbakwunye; gbanwee dabere na mkpa nyocha.
- Nchekwa: Na-echekwa na -20 ° C (ntụ ntụ, 3 afọ) ma ọ bụ -80 ° C (ihe ngwọta, 1 afọ). Chebe site na ìhè na mmiri .
- Solubility:
- H2O: 125 mg/mL (akwado sonication).
- DMSO: 50 mg/mL.
Gịnị mere Họrọ Anyị?
- Nkwanye nnukwu: 3,000kg ngwaahịa njikere nwere nnukwu mbelata yana COA n'efu (Akwụkwọ nyocha) .
- Nkwanye mma: Nnwale siri ike maka nyocha NR, ọla dị arọ, na njirimara NMR.
- Nnyefe zuru ụwa ọnụ: Mbupu ngwa ngwa na nkwado raara onwe ya nye maka nyocha na mmekorita azụmahịa.
Kpọtụrụ anyị taa maka nlele, ọnụahịa, na usoro omenala ahaziri maka mkpa gị!
Keywords: NAD + precursor, Vitamin B3, mgbochi ịka nká, NR chloride nnukwu ntụ ntụ, FDA GRAS, crystalline nicotinamide riboside, NAD + booster
