According to a study by the American Heart Association, cannabis, a psychoactive component of cannabis, causes inflammation and oxidative stress, while inflammation and oxidative stress affect the inner wall of blood vessels. And related to the occurrence of heart disease. The study also found that in laboratory tests, a compound found in soy can prevent damage to the inner walls of the heart and circulatory blood vessels, and these findings can be used as a way to prevent cardiovascular side effects from recreational cannabis and medical cannabis.
In the study, the researchers examined endothelial cells from stem cells from five healthy people (such as those arranged on blood vessels). They also used a laboratory technique called linear electromyography to detect the response of mouse arteries to THC. After exposing these cells to THC, they found:
· THC exposure causes inflammation and oxidative stress, which is known to affect the inner wall of blood vessels and is associated with the development of heart disease;
· When people take FDA-approved drugs that contain synthetic THC, they also have cardiovascular side effects, including changes in heart rate and blood pressure;
· Eliminate the effects of THC exposure on endothelial cells by laboratory techniques that block THC entry into the CB1 receptor;
· The antioxidant JW-1 found in soybeans can eliminate the effects of THC.
Since marijuana has been legalized around the world, the popularity of marijuana in the market is very hot, especially in the past year, its popularity has increased significantly. The industry has seen a surge in THC’s new product applications, such as the infusion of THC wines. THC&CBD wines from Saka Wines, Calif., are said to relieve pain, reduce inflammation, improve muscles, increase attention and provide other health benefits.
The study’s lead author, Thomas Wei, a professor of pharmacology at the National University of Taiwan and a member of the American Heart Association, said the drugs could be used to reduce nausea and vomiting caused by chemotherapy and to increase the number of patients with acquired immunodeficiency syndrome. appetite. The aim of the study was to study the mechanisms of damage caused by cannabis and to develop new drugs to prevent these side effects. With the rapid growth of cannabis use worldwide, a new method of protecting blood vessels without causing mental side effects will have important clinical implications.
The effect of THC occurs after it binds to one of the two cannabinoid receptors (CB1 and CB2). These two receptors are found throughout the brain and body and are also affected by naturally occurring cannabinoids. Previous attempts have been made to obtain health benefits by blocking the CB1 receptor, but it has finally proven to be problematic: a drug that blocks CB1 is approved for the treatment of obesity in Europe, but due to severe mental side effects, The drug had to be withdrawn.
In contrast, the compound JW-1, which is an antioxidant, may have neuroprotective effects. But Professor Wei also pointed out that if you have heart disease, please consult a doctor before using marijuana or synthetic drugs containing THC. Because marijuana may have more serious consequences for the cardiovascular system of patients who already have heart disease.
Researchers are currently expanding their research to detect differences between cells from ordinary cannabis users, as well as people who smoke and smoke marijuana. In addition, researchers are also studying the effects of THC and another cannabinoid CBD.
Similarly, according to a study by the University of Guelph in Canada, cannabis was found to produce potent analgesic factors that are 30 times more effective at reducing inflammation than aspirin. The researchers point out that the discovery reveals the potential of a natural pain relief method that effectively relieves pain without the risk of addiction like other painkillers.
Post time: Aug-15-2019