Zita reChigadzirwa: Tranexamic Acid 98% neHPLC
Nhamba yeCAS:1197-18-8
Molecular Formula: C₈H₁₅NO₂
Molecular Weight: 157.21 g/mol
Kuchena: ≥98% (HPLC)
Kuonekwa: White crystalline powder
Kuchengetedza: +4 ° C (nguva pfupi), -20 ° C (kwenguva refu)
Kushandisa: Pharmaceutical, Cosmetics, Research
1. Chigadzirwa Overview
Tranexamic Acid (TXA), inonzi synthetic lysine analog, inoshandiswa zvakanyanya seantifibrinolytic agent kuderedza kubuda kweropa mukuvhiya uye kukuvadzwa. Ichi chigadzirwa chinogadzirwa pasi pekusimba kwehutongi hwemhando, kuve nechokwadi chekuchena kwe ≥98% sekusimbiswa neHigh-Performance Liquid Chromatography (HPLC). Chimiro chayo chemakemikari (trans-4- (aminomethyl) cyclohexanecarboxylic acid) uye kugadzikana kwepamusoro kunoita kuti ive yakakodzera kune akasiyana maapplication, kusanganisira:
- Kushandiswa Kwezvokurapa: Kudzora ropa, kukuvara kwehuropi (TBI) kurapwa.
- Cosmetics: Ganda rekuchenesa mafuta anonangana ne hyperpigmentation.
- Tsvagiridzo: Kuvandudza nzira yekuvandudza uye zvidzidzo zve pharmacokinetic.
2. Chemical uye Physical Properties
- IUPAC Zita: 4- (Aminomethyl) cyclohexane-1-carboxylic acid
- KUNYEMWERERA: NC[C@@H]1CCC@HC(=O)O
- InChI Kiyi: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
- Kunyungudika: 386°C (December)
- Solubility: Soluble mumvura (1N HCl, pH-adjusted buffers), methanol, uye acetonitrile.
3. Kuvimbiswa Kwehutano
3.1 HPLC Ongororo
Yedu HPLC nzira inovimbisa chaiyo quantification uye kusachena profiling:
- Column: XBridge C18 (4.6 mm × 250 mm, 5 μm) kana yakaenzana.
- Nharembozha: Methanol:acetate buffer (20 mM, pH 4) (75:25 v/v).
- Kuyerera Kweyero: 0.8–0.9 mL/min.
- Kuonekwa: UV pa220 nm kana 570 nm (post-derivatization ne1% ninhydrin).
- Kukodzera Sistimu:
- Kururamisa: ≤2% CV yenzvimbo yepamusoro (6 replicates).
- Kudzoreredza: 98-102% (80%, 100%, 120% spiked mazinga).
3.2 Kusachena Mbiri
- Kusachena A: ≤0.1%.
- Kusachena B: ≤0.2%.
- Zvose Zvisina Kuchena: ≤0.2%.
- Halides (seCl⁻): ≤140 ppm.
3.3 Kugadzikana
- pH Kugadzikana: Inoenderana nemabhafa (pH 2-7.4) uye zvakajairika IV mhinduro (semuenzaniso, fructose, sodium chloride).
- Thermal Kugadzikana: Yakagadzikana pa 37 ° C kwemaawa makumi maviri nemana mumatrices ehupenyu.
4. Zvikumbiro
4.1 Kushandiswa Kwekurapa
- Trauma Care: Inoderedza kufa kwevarwere veTBI ne20% (CRASH-3 muyedzo).
- Kuvhiya: Inoderedza kurasikirwa kweropa kweperioperative (kuvhiya kwemapfupa, kuvhiyiwa kwemoyo).
4.2 Zvizoro
- Mechanism: Inhibits plasmin-induced melanogenesis nekuvhara lysine-binding nzvimbo.
- Magadzirirwo: 3% TXA makirimu e melasma uye hyperpigmentation.
- Kuchengetedza: Kushandiswa kwepamusoro kunodzivirira njodzi dzehurongwa (semuenzaniso, thrombosis).
4.3 Tsvakurudzo & Kubudirira
- Analytical Methods:Synthesis: Prodrug interconversion zvidzidzo pasi pemamiriro e acidic.
- UPLC-MS/MS: Yekuongorora plasma (LOD: 0.1 ppm).
- Fluorimetry: Derivatization ne NDA/CN (5-minute reaction).
5. Packaging & Storage
- Primary Packaging: Akavharwa mabhegi ealuminium ane desiccant.
- Sherufu Hupenyu: Mwedzi makumi maviri nemana pa -20°C.
- Kutumira: Ambient tembiricha (yakatenderwa kwemaawa 72).
6. Kuchengetedza uye Kuteerera
- Kubata: Shandisa PPE (magirovhosi, magirazi) kudzivirira inhalation/kubata.
- Regulatory Status: Inopindirana neUSP, EP, uye JP pharmacopeias.
- Toxicity: LD₅₀ (muromo, rat)> 5,000 mg / kg; isiri-carcinogenic.
7. References
- Sistimu yekukodzera kusimbiswa kweHPLC.
- Calibration curve uye derivatization protocol.
- UPLC-MS/MS nzira yekuenzanisa.
- Mutengo-kubudirira mukutarisira kushungurudzika.
- Cosmetic kugadzirisa kugadzikana.
Keywords: Tranexamic Acid 98% HPLC, Antifibrinolytic Agent, Skin Whitening, Trauma Care, UPLC-MS/MS, CRASH-3 Trial, Melasma Treatment
Tsanangudzo yeMeta: High-purity Tranexamic Acid (≥98% neHPLC) yekurapa, zvizoro, uye kushandiswa kwekutsvaga. Yakagadziriswa HPLC nzira, inodhura-inoshanda trauma care, uye yakachengeteka topical maumbirwo. CAS 1197-18-8.
