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Product name: Ginsenoside RG3
Source: Ginseng Stem & Leaf
Botanic Name: Panax Ginseng C.A. Meyer
CAS number: 14197-60-5
Appearance: Light yellow to yellowish brown powder
Specifications: 1%-10% Ginsenoside Rg3
What is ginsenoside Rg3?
Before we introduce ginsenoside Rg3 powder, let’s first know something about Ginseng and ginsenosides.
Ginseng and ginsenosides
Panax Ginseng C.A. Meyer, simply called Ginseng, is one traditional Chinese medicinal herb. Asian countries such as China, Japan, and Korea have used it for a long history. The major components playing an important role are kinds of ginsenosides, which exist in the whole ginseng herb including root, stem, and leaf. So far, people have identified and isolated more than 40 kinds of ginsenosides.
According to the difference in carbon skeletons, ginsenosides are divided into the dammarane family and the oleanane family. The dammarane family also includes two major groups: protopanaxadiols and protopanaxatriols. For example, ginsenosides Rb1, Rb2, Rg3, Rh2, and Rh3 belong to protopanaxadiols; Rg1, Rh1, and Rg2 belong to protopanaxatriols. Ginsenosides have a wide spectrum of physiological functions, including energy enhancement, cognitive improvement, anti-inflammatory, antioxidant, etc. Hereafter list some well-known functions of ginsenosides:
- Ginsenosides can promote energy production and fight fatigue
- Ginsenosides enhance insulin levels and lower blood sugar
- Ginsenosides improve immunity, especially for cancer patients
- Ginsenosides benefit brain health and improve memory
- Ginsenosides promote an inflammatory response and fight oxidative stress
- Ginsenosides can improve erectile dysfunction symptoms
Ginsenoside Rg3 is rich in Korean red ginseng, which is gotten by steaming Panax ginseng root. Even so, the content of ginsenoside Rg3 is still a tiny amount in red ginseng root. There are two epimers 20(R)-Ginsenoside Rg3 and 20(S)-Ginsenoside Rg3. Ginsenoside Rg3 structure as below:
20(S)-ginsenoside Rg3
Cas No.: 14197-60-5
Molecular Formula: C42H72O13
Molecular Weight: 785.025g/mol
20(R)-ginsenoside Rg3
Cas No.:38243-03-7
Molecular Formula: C42H72O13
Molecular Weight: 785.025g/mol
What are the differences between 20(S)-ginsenoside Rg3 and 20(R)-ginsenoside Rg3?
- 20(S) -Ginsenoside Rg3 has better solubility than 20(R)-Ginsenoside Rg3
- Ginsenoside Rg3 can suppress tumor growth and angiogenesis, and 20(S)-ginsenoside exhibits a better effect than 20(R) form, whereas 20(R) form performs a better function on invasion and metastasis of cancer cells.
Ginsenoside Rg3 Powder health benefits
(1)Neuroprotection and Anti-aging
Ginsenoside Rg3 powder can prevent inflammatory neurotoxicity and plays a role in anti-aging. Animal studies proved that ginsenoside Rg3 could prevent astrocytic senescence to delay aging. What is more, ginsenoside also can stimulate skin elastin and collagen synthesis, BTGIN’s brand Herbal Iron formulas ginsenoside Rg3 together with compound K(simply called ginsenoside CK) in their cream. You can find their cream on Amazon.
(2)Sustain a healthy inflammatory response
As powerful inflammatory factor inhibitors, ginsenosides Rg3 can effectively promote the resolution of inflammation. This is accomplished through suppressing pro-inflammatory cytokine output and adjusting inflammatory signaling pathways. Based on this principle.
(3)Improve memory and cognitive health
Scientific studies proved that Ginsenoside Rg3 could repair memory damage and enhance learning obviously by 21days’ daily intake.
What is more, ginsenoside Rg3 exhibits other functions including stem cell health promotion, healthy cell metabolism improvement as well as molecular integrity promotion, etc.
(1)How do you produce your ginsenoside Rg3?
unlike regular production technology extracting ginsenoside Rg3 from red ginseng root, we manufacture it by unique enzymatic conversion technology from ginseng stem and leaf. Ginsenoside Rd is deglycosylated to form ginsenoside Rg3. This new technology was awarded for scientific and technological advancement by the local government. Our advanced technology not only creates high concentrated ginsenoside Rg3 but also reduces cost much.
(2)What other ginseng extract specifications do you offer?
Ginseng Stem&Leaf Extract 5%-80% ginsenosides by UV
Ginseng Stem&Leaf Extract 5%-45% ginsenosides by HPLC
Ginseng Root Extract 1%-40% ginsenosides by HPLC
(3)What standard of pesticide residue does your ginsenoside Rg3 conform to?
We can offer all versions of ginsenosides, the pesticide residue meeting CP2015, USP<561>, EC<396>. Most important, we can provide ginsenosides with PESTICIDES FREE, which is produced by our unique pesticide residue removal process.
(4)What dosage is Ginsenoside Rg3?
The suggested dosage is 20mg daily. LifeExtension uses Ginsenosides Rg3 [from Asian ginseng (Panax) C.A. Mey. extract (stem, leaf) (std. to 10% ginsenosides Rg3)] in their GEROPROTECT ® Longevity A.I.™ supplement, which is presented by a collaboration of Life Extension and Insilico Medicine.
(5)Is ginsenoside Rg3 is safe?
Animals tested on mice and dogs prove that ginsenoside Rg3 is remarkably nontoxic as well.
Ginsenoside Rg3 plays an important role in its effect on the Na+ channel. Treatment with Ginsenoside Rg3 reversibly inhibits the inward Na+ peak current (INa) with an IC50 of 32.2±4.5 μM, and the inhibition is voltage-dependent[1]. Ginsenoside Rg3 at 100 μM inhibits the hKv1.4 channel currents by an average of 65%.The Ginsenoside Rg3 effect is concentration-dependent and reversible. The IC50 value and Hill coefficient are 32.6±2.2 μM and 1.59±0.13, respectively[2]. Ginsenoside Rg3 shows the significant inhibition of NF-κB activity thereby reduced COX-2 expression. To examine the cytotoxicity of Ginsenoside Rg3 on IL-1β-induced inflamed A549 cells, the cells are firstly treated with IL-1β (10 ng/mL) for 4 h and treated with 100 to 900 ng/mL concentration of Ginsenoside Rg3 for 12 h. Cell viability is analyzed using an MTT assay. There is no observed cytotoxicity of Ginsenoside Rg3 in IL-1β-induced inflamed A549 cells compared to only PBS-treated cells (Con).To obtain the anti-inflammatory effects of Ginsenoside Rg3 on inflammation induced human lung epithelial cells, A549 cells inflammation is induced by IL-1β (10 ng/mL) and then treated by 5 μM of Dexamethasone (Dex) or 900 nM of Rg3. The NF-κB activation is analyzed by a western blot analysis to evaluate the effect of Ginsenoside Rg3 treatment on A549 cells. Phospho-NF-κB p65/total NF-κB p65 densitometry in the cells treated with Rg3 shows the significant decrease compared to IL-1β-induced inflamed A549 cells. The meaning of reducing the ratio of p-p65/p65 by Rg3 treatment is associated with NF-κB activation. Ginsenoside Rg3 also downregulates the expression of COX-2 effectively[3].
Ginsenoside Rg3 ((20S)-Rg3) is an Aβ-lowering Natural Compound. APP/PS1 mice are treated with Ginsenoside Rg3 once a day for 4 weeks by intraperitoneal injection (10 mg/kg/day). Aβ ELISA analysis of brain tissues reveal that Ginsenoside Rg3 treatment results in a significant reduction of Aβ40 and Aβ42 in the brain[4].
