Sunan samfur:7,8-Dihydroxyflavone

CAS No:38183-03-87

Wani Sunan: 7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;

DIHYDROXYFLAVONE, 7,8-(RG);7,8-Dihydroxyflavone hydrate;

7,8-dihydroxy-2-phenyl-1-benzopyran-4-daya,,8-Dihydroxyflavone (7,8-DHF)

Musamman: 98.0%

Launi: Yellow foda tare da halayyar wari da dandano

Matsayin GMO: GMO Kyauta

Shiryawa: a cikin 25kgs fiber ganguna

Adana: Ajiye akwati a buɗe a wuri mai sanyi, busasshiyar wuri, Nisantar haske mai ƙarfi

Rayuwar Shelf: watanni 24 daga ranar samarwa

Bayanin samfur: 7,8-Dihydroxyflavone (7,8-DHF)- Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru

Dubawa
7,8-Dihydroxyflavone (7,8-DHF), wani flavonoid da ke faruwa ta halitta wanda aka samu a cikin tsire-tsire kamar su.Tridax farashinkumaGodmania aesculifolia, wani fili ne mai jujjuyawar bioactive tare da hanyoyin aiki biyu. Yana aiki azaman agonist mai karɓar mai karɓa na TrkB (kwaikwayi nau'in neurotrophic da aka samo daga kwakwalwa, BDNF) da mai hana mai hanawa na pyridoxal phosphatase (PDXP). Waɗannan kaddarorin sun sa ya zama ɗan takara mai ban sha'awa don bincike na jijiyoyin jini, haɓaka fahimi, da aikace-aikacen warkewa.

Mabuɗin Siffofin

1. Bayanan Halitta
   • Chemical Formula: C₁₅H₀O₄
   • Lambar CAS:38183-03-8
   • Nauyin Kwayoyin Halitta: 254.24 g/mol
   • Tsafta: ≥98% (tabbatar HPLC)
   • Solubility:

• Mai narkewa sosai a cikin DMSO (har zuwa 100 mM) da ethanol (25 mM)
• Mai narkewa cikin ruwa (<1 mg/mL).

2. Adana & Gudanarwa
   • Foda: Ajiye a -20 ° C a cikin yanayin da ba shi da kyau (kwance don shekaru 3).
   • Magani: Aliquot da adanawa a -80 ° C (bargawar shekaru 1-2).
   • Kariyar Tsaro:

• Yi amfani da safofin hannu masu kariya, tabarau, da riguna na lab.
• Guji shakar numfashi, ciki, ko tuntuɓar fata kai tsaye.
• Bi rabe-raben haɗari na GHS (m guba mai guba, ido/gashin fata).

Hanyoyin Ayyuka

1. TrkB Mai karɓar Agonism
   • Yana ɗaure zuwa TrkB tare da babban kusanci (Kd ≈ 320 nM), kunna hanyoyin ƙasa (PI3K/Akt, MAPK) don haɓakawa:

• Neurogenesis da synaptic filastik.
• Neuroprotection daga damuwa na oxidative, excitotoxicity, da apoptosis.
• Haɓaka fahimi a cikin samfuran cutar Alzheimer, rauni mai rauni a cikin kwakwalwa, da baƙin ciki.

2. PDXP hanawa
   • Gasa yana hana pyridoxal phosphatase (PDXP), ƙara pyridoxal 5'-phosphate (PLP), nau'in bitamin B5 mai aiki.
   • Amfani:

• Yana mayar da raguwar PLP mai dogaro da shekaru a cikin hippocampus.
• Yana haɓaka koyo da ƙwaƙwalwa a cikin ƙira.

3. Ƙarin Tasiri
   • Ayyukan Antioxidant: Yana hana hanyoyin JNK/NF-κB don rage kumburi.
   • Tsarin Metabolic: Yana haɓaka ɗaukar glucose kuma yana rage matakan glucose na jini.

Aikace-aikace

1. Binciken Jijiya
   • Nazarin neuroprotection a cikin Alzheimer's, Parkinson's, da samfuran bugun jini na ischemic.
   • Bincika siginar BDNF/TrkB a cikin filastik synaptic da rikicewar yanayi.
2. Kariyar Lafiyar Fahimi
   • Yiwuwar amfani a cikin nootropics don haɓaka ƙwaƙwalwar ajiya da neuroplasticity.
3. Ci gaban warkewa
   • Bincika dabarun manufa biyu (TrkB + PDXP) don raguwar fahimi mai alaƙa da rashi bitamin B6.

Tsaro & Sashe

• Guba: Nazarin preclinical ba ya nuna wani muhimmin guba a allurai na warkewa.
• Shawarar Sashin (amfanin bincike kawai):
  • In vitro: 250 nM-10 µM.
  • A cikin vivo (mice): 50-100 mg/kg/rana baki ko ta hanyar allurar intraperitoneal.

Me yasa Zabi 7,8-DHF?

• Bayanan Ayyukan Dual-Action: Haɗa kunnawa TrkB da hana PDXP don fa'idodi masu yawa.
• Ƙwallon Ƙwaƙwalwar Jini-Ƙwaƙwalwa: Mai tasiri a tsarin tsarin juyayi na tsakiya.
• Binciken Bincike: An tabbatar da shi a cikin fiye da 50 bincike na asali don neuroprotection, haɓaka fahimta, da tsarin rayuwa.

Mahimman kalmomi:TrkB agonist, PDXP inhibitor, neuroprotective wakili, mai haɓaka fahimi, fa'idodin flavonoid, 7,8-DHF solubility, binciken Alzheimer, BDNF mimic.