L-5-Methyltetrahydrofolate Calcium Powder

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Product Name Bulk L-5-MTHF Calcium powder
Others (6S)-5-methyltetrahydrofolate calcium, L-5-MTHF-Ca, Calcium l-methylfolate, L-5-MTHF Ca, calcium l methylfolate, Calcium levomefolate, Calcium L-5-Methyltetrahydrofolate
CAS Number 151533-22-1
Molecular Formula C20H23CaN7O6
Specifications 99%
Molecular Weight 497.5
Appearance/color White to light yellow crystalline powder
Benefits As a source of folate for Mood, Homocysteine Methylation, Nerve Health, Immune Support

What is L-5-methyltetrahydrofolate Calcium?

L-5-methyltetrahydrofolate calcium powder (L-5-MTHF-Ca) is a biologically active form of folate, an essential B-vitamin (Vitamin B-9) your body needs for various functions. This synthetic compound is derived from folic acid, the naturally occurring form of folate, and is used as a dietary supplement to support mood, Homocysteine Methylation, Nerve Health, Immune Support, etc.

This compound is also known by several other names such as:

  • Calcium L-5-methyltetrahydrofolate
  • L-methylfolate calcium
  • Levomefolic acid
  • (6S)-5-methyltetrahydrofolate
  • (6S)-5-MTHF

Calcium L-5-methyltetrahydrofolate Vs Folic Acid

Chemical and Physical Features of Folic Acid

IUPAC name N-(4-{[(2-amino-4-oxo-1H-pteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
Other names Vitamin B9, Pteroylglutamic acid
CAS Number 59-30-3
Chemical formula C19H19N7O6
Molar mass 441.4 g/mol
Appearance Yellow-orange crystalline powder
Density 1.59 g/cm3
Melting point 250 °C (decomposes)

Why is L-5-MTHF Ca Better Than Folic Acid?

Calcium L-5-methyltetrahydrofolate (L-5-MTHF Ca) is a bioavailable alternative to folic acid in supplements, offering several advantages:

Safer and More Stable

L-5-MTHF Ca has a reduced potential for masking the symptoms of vitamin B12 deficiency, making it a safer option. It also exhibits high stability, ensuring that its benefits are retained during storage and consumption.

Better Bioavailability

This form of folate has better bioavailability than folic acid, meaning your body can absorb and utilize it more efficiently. This allows you to receive the full benefits of the supplement.

No Need for Metabolism

While the body must metabolize folic acid into the active form of folate, L-5-MTHF Ca can be absorbed directly without undergoing additional metabolic steps. This immediate bioavailability ensures a consistent supply of folate for your body’s needs.

Suitable for Various Populations

L-5-MTHF Ca is suitable for individuals with MTHFR gene mutations, making it an inclusive choice for many. Folic acid may not be well-tolerated or properly metabolized by those with certain genetic variations, so L-5-MTHF Ca is a more fitting option for these populations.

Ultra Pure with 99% Purity

Calcium L-5-methyltetrahydrofolate powder with 99% purity provides an exceptionally high-quality supplement option, ensuring you receive the best product for your nutritional needs.

In summary, L-5-MTHF Ca offers advantages over traditional folic acid, making it a preferred choice for many individuals. Its superior bioavailability, direct absorption, suitability for diverse populations, and ultra-pure formulation contribute to its increased effectiveness in meeting your body’s folate requirements.

L-5-Methyltetrahydrofolate Calcium Manufacturing Process

The synthesis process of L-5-MTHF-Ca involves the reduction of folic acid to tetrahydrofolic acid, followed by methylation and diastereoselective crystallization in water to form the calcium salt. To produce L-5-Methyltetrahydrofolate Calcium powder, you’ll need the following raw materials:

  • Synthetic folic acid
  • Sodium borohydride
  • Formaldehyde
  • Calcium salt

The initial step involves the reduction of folic acid to tetrahydrofolic acid using sodium borohydride. This reaction ensures a stable structure for the vitamin, which is crucial to its absorption and function in your body. Next, formaldehyde is added to the tetrahydrofolic acid to form 5,10-MTHF, another essential intermediate compound.

Synthesis and Crystallization

After obtaining 5,10-MTHF, use sodium borohydride again to conduct a further reduction step. This reaction will yield the desired L-5-MTHF compound. At this point, the critical aspect of diastereoselective crystallization comes into play. When crystallizing L-5-MTHF in water, add a calcium salt, forming calcium L-5-MTHF – a white to light yellowish, almost odorless, water-soluble crystalline powder. This process ensures the final product’s correct ratio of L and D isomers.

Following GMP guidelines throughout the manufacturing process is essential to guarantee the highest quality and purity levels for your L-5-Methyletrahydrofolate Calcium powder. By adhering to these guidelines, you can ensure the potency and safety of your dietary supplement.

By following this manufacturing process, the resulting L-5-MTHF-Ca will contain not less than (NLT) 95.0% and not more than (NMT) 102.0% of calcium 5-methyltetrahydrofolate, as specified by the USP standards. This high 99% purity level ensures that the final powder is ideal for manufacturing dietary supplements, which is valuable for people seeking to enhance their folate intake and overall health.

Benefits of L-5-methyltetrahydrofolate Calcium

Mood Enhancement

L-5-Methyltetrahydrofolate Calcium, or L-5-MTHF for short, can positively impact your mood. As the active form of folate, it plays a critical role in producing and maintaining neurotransmitters like serotonin, dopamine, and norepinephrine. By supporting the synthesis of these neurotransmitters, L-5-MTHF helps keep your mood balanced and contributes to emotional well-being.

Homocysteine Methylation

Another great benefit of L-5-MTHF is its ability to regulate homocysteine levels in your body. High homocysteine is a risk factor for cardiovascular disease. L-5-MTHF is a key player in the methylation process which helps convert homocysteine into methionine, an essential amino acid. This conversion not only reduces homocysteine levels but also supports cardiovascular health.

Nerve Health

L-5-MTHF not only plays a crucial role in neurotransmitter synthesis but also in nerve health. It supports producing and maintaining new nerve cells, ensuring proper nerve function and communication. By supplementing with L-5-MTHF, you can ensure your nervous system stays healthy and functioning at its best.

Immune Support

Your immune system relies on various nutrients and minerals to function optimally, and L-5-MTHF is no exception. It contributes to the healthy functioning of your immune system by aiding in DNA expression and repair. A strong immune system is crucial for protecting your body against various diseases and infections.

Addressing Folate Deficiencies and Neural Tube Defects

L-5-MTHF is an excellent nutritional supplement to address folate deficiencies, which can lead to serious health consequences, especially during pregnancy. Folate is essential for prenatal development and helps reduce the risk of neural tube defects. By supplementing with L-5-MTHF, you can support healthy pregnancy outcomes and ensure proper fetal development.

In summary, L-5-Methyltetrahydrofolate Calcium is a versatile and essential nutrient that offers a range of benefits to support your overall health – from improved mood and cardiovascular health to nerve function and immune system enhancement. By supplementing with L-5-MTHF, you’re taking a proactive step towards a brighter, healthier future.

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