In 1913, Swedish scientist Professor Kylin discovered the sticky slip component of kelp, fucoidan, at Uppsala University. Also known as “fucoidan”, “fucoidan sulfate”, “fucoidan”, “fucoidan sulfate”, etc., the English name is “Fucoidan”. It is a water-soluble polysaccharide substance composed of fucose containing sulfate groups. It is mainly present in the surface slime of brown algae (such as seaweed, wakame spores, and kelp). The content is about 0.1%, and the content in dry kelp is about 1%. It is a very valuable seaweed active substance.
First, the effectiveness of fucoidan
Japan is currently the country with the longest life span in the world. At the same time, Japan has one of the lowest rates of chronic diseases. According to nutritionists, one of the most important reasons for the health of Japanese people may be related to regular consumption of seaweed foods. Fucoidan contained in brown algae such as kelp is an active substance with various physiological functions. Although it was discovered by Professor Kylin in 1913, it was not until 1996 that the Fucoidan was published at the 55th Japanese Cancer Society Conference. The report that “can induce cancer cell apoptosis” has aroused widespread concern in the academic community and caused a boom in research.
At present, the medical community is conducting research on various biological functions of fucoidan, and has published thousands of papers in international medical journals, confirming that fucoidan has various biological functions, such as anti-tumor, improving gastrointestinal tract, and antioxidant , Enhance immunity, antithrombotic, lower blood pressure, antiviral effects.
(I) Fucoidan improves gastrointestinal efficacy
Helicobacter pylori is a helical, microaerobic, gram-negative bacilli that are very demanding on growth conditions. It is the only microbial species currently known to survive in the human stomach. Helicobacter pylori infection causes gastritis and digestive tract. Ulcers, lymphoproliferative gastric lymphomas, etc., have a poor prognosis for gastric cancer.
The pathogenic mechanisms of H. pylori include: (1) adhesion: H. pylori can pass through as a mucus layer and adhere to gastric epithelial cells; (2) neutralize gastric acid for the benefit of survival: H. pylori releases urease, and Urea in the stomach reacts to generate ammonia gas, which neutralizes gastric acid; (3) destroys gastric mucosa: Helicobacter pylori releases VacA toxin and erodes the surface cells of gastric mucosa; (4) produces toxin chloramine: ammonia gas directly erodes gastric mucosa, and reactive oxygen The reaction produces a more toxic chloramine; (5) Causes an inflammatory response: In order to defend against Helicobacter pylori, a large number of white blood cells gather on the gastric mucosa to produce an inflammatory response.
The effects of fucoidan against Helicobacter pylori include:
1. Inhibition of Helicobacter pylori proliferation;
In 2014, the Yun-Bae Kim research team at Chungbuk National University in South Korea published a study showing that fucoidan has a very good antibacterial effect, and the fucoidan at a concentration of 100µg / mL can completely inhibit the proliferation of H. pylori. (Lab Anim Res2014: 30 (1), 28-34.)
2. Prevent the adhesion and invasion of Helicobacter pylori;
Fucoidan contains sulfate groups and can bind to Helicobacter pylori to prevent it from adhering to gastric epithelial cells. At the same time, Fucoidan can inhibit urease production and protect the acidic environment of the stomach.
3. Antioxidant effect, reduce toxin production;
Fucoidan is a good antioxidant, which can quickly scavenge oxygen free radicals and reduce the production of the harmful toxin chloramine.
4. Anti-inflammatory effect.
Fucoidan can inhibit the activity of selective lectin, complement and heparanase, and reduce the inflammatory response. (Helicobacter, 2015, 20, 89–97.)
In addition, the researchers found that fucoidan has a significant effect on improving intestinal health and has two-way conditioning effect on the intestine: improving constipation and enteritis.
In 2017, a research team from Professor Ryuji Takeda of Kansai University of Welfare Sciences in Japan conducted a study. They selected 30 patients with constipation and divided them into two groups. The experimental group was given 1 g of fucoidan and the control group was given a placebo. Two months after the test, it was found that the number of defecation days per week in the test group taking fucoidan increased from an average of 2.7 days to 4.6 days, and the defecation volume and softness increased significantly. (Functional Foods in Health and Disease 2017, 7: 735-742.)
In 2015, a team of Professor Nuri Gueven of the University of Tasmania, Australia, found that fucoidan can effectively improve enteritis in mice, on the one hand, it can help mice restore weight and increase the hardness of defecation; on the other hand, it can reduce the weight of the colon and spleen. Reduces inflammation in the body. (PLoS ONE 2015, 10: e0128453.)
B) Antitumor effect of fucoidan
The research on the antitumor effect of fucoidan is currently the most concerned by academic circles, and a lot of research results have been obtained.
1. Regulation of tumor cell cycle
In 2015, Professor Lee Sang Hun and others at Soonchunhyang University in South Korea and other researchers found that fucoidan inhibits the expression of cyclin Cyclin and cyclin kinase CDK in tumor cells by regulating the growth cycle of human colon cancer cells, affecting the normal mitosis of tumor cells. Stagnate tumor cells in the pre-mitotic phase and inhibit tumor cell proliferation. (Molecular Medicine Reports, 2015, 12, 3446.)
2.Induction of tumor cell apoptosis
In 2012, a study published by the Quan Li research team at Qingdao University found that fucoidan can activate the apoptosis signal of tumor cells-Bax apoptosis protein, cause DNA damage to breast cancer cells, chromosome aggregation, and induce spontaneous apoptosis of tumor cells. , Inhibited the growth of tumor cells in mice. (Plos One, 2012, 7, e43483.)
3.Inhibit tumor cell metastasis
In 2015, Chang-Jer Wu and other researchers from the National Taiwan Ocean University published research showing that fucoidan can increase tissue inhibitory factor (TIMP) expression and down-regulate matrix metalloproteinase (MMP) expression, thereby inhibiting tumor cell metastasis . (Mar. Drugs 2015, 13, 1882.)
4.Inhibit tumor angiogenesis
In 2015, the Tz-Chong Chou research team at the Taiwan Medical Center found that fucoidan can reduce the production of vascular endothelial growth factor (VEGF), inhibit the neovascularization of tumors, cut off the nutritional supply of tumors, starve the tumors to the greatest extent Block the spread and metastasis of tumor cells. (Mar. Drugs 2015, 13, 4436.)
5.Activate the body’s immune system
In 2006, Professor Takahisa Nakano of Kitasatouniversity University in Japan discovered that fucoidan can enhance the body’s immunity and use the patient’s own immune system to specifically kill cancer cells. After the fucoidan enters the intestinal tract, it can be recognized by immune cells, generate signals that activate the immune system, and activate NK cells, B cells, and T cells, thereby producing antibodies that bind to cancer cells and T cells that kill cancer cells. Specific killing of cancer cells, inhibiting cancer cell growth. (Planta Medica, 2006, 72, 1415.)
Production of Fucoidan
The content of sulfate groups in the molecular structure of fucoidan is an important indicator that determines its physiological activity, and it is also an important content of the structure-activity relationship of fucoidan. Therefore, the content of sulfate group is an important parameter for evaluating fucoidan quality and structure-activity relationship.
Recently, the fucoidan polysaccharide food production license was finally certified by the Food and Drug Administration and awarded to Qingdao Mingyue Seaweed Group, which means that Mingyue Seaweed Group has been deeply cultivating the ocean for more than 50 years. Obtain official certification. It is reported that Mingyue Seaweed Group has built a fucoidan production line with an annual output of 10 tons. In the future, it will give full play to its “medicine and food homology” effect and glow in the functional food field of the large health industry.
Mingyue Seaweed Group, as an enterprise approved for the production of fucoidan food, has many years of production experience. The fucoidan produced by it is a technical upgrade product of the original kelp concentrate / powder. Using high-quality food-grade brown algae as raw material, further purification and separation based on natural extraction technology, not only improves the flavor and taste of the product, but also increases the fucoidan polysaccharide content (purity), which can be used in many fields such as functional foods and health foods. . It has the advantages of high product purity and high content of functional groups; heavy metals removal, high safety; desalination and fishiness, taste and flavor improvement.
Application of Fucoidan
At present, there are many fucoidan products developed and applied in Japan, South Korea, the United States and other countries, such as extra concentrated fucoidan, fucoidan extract raw capsules, and lubricating seaweed super fucoidan. Functional foods such as Seaweed Group’s Qingyou Le, Rockweed Treasure, Brown Algae Plant Beverage
In recent years, the “Report on the Status of Chinese Residents’ Nutrition and Chronic Diseases” shows that the dietary structure of Chinese residents has changed, and the prevalence of chronic diseases is on the rise. Large health projects centered on “treating diseases” have attracted much attention. Using fucoidan to develop and produce more functional foods will fully explore the beneficial value of fucoidan to give life and health, which is of great significance for the development of a “healthy medicine and food homology” large health industry.
Post time: Mar-24-2020