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The world is getting old. But has it become healthier? The U.S. Census Bureau predicts that in the United States alone, the number of elderly people over 65 will eventually exceed the number of children. The bureau calls 2030 an “important demographic turning point in American history,” during which all baby boomers will be over 65 years old.
The increase in global life expectancy, the attendant medical challenges and the growth trend of health-conscious consumers provide huge opportunities for the dietary supplement market.
The need for science-based anti-greasy agents remains to be developed, and this protective agent supports healthy aging and may even slow down the aging process. NMN is such a molecule.
NMN is a natural product of vitamin B3 metabolism. It can be found in our body and is found in small amounts in some healthy foods, such as broccoli, edamame and cucumber peel. NMN is a metabolite necessary to produce energy and maintain life in the human body. NMN is the precursor of the important molecule NAD +, which supports a variety of functions necessary for health and healthy aging. Between the ages of 40 and 60, the level of NAD+ in human tissues drops by at least 50%. Taking NMN can promote the natural production of NAD + and help fight aging.
1. The structure is unstable. The low-density first-generation NMN does not have good fluidity. Effepharm’s improved NMN version will reduce production costs through better powder flowability, thereby increasing production capacity because it will be easier to operate through the machine. Moreover, since the low density version is difficult to mix uniformly, this version will result in a more uniform capsule dosage. Finally, the low-density NMN powder compressed in the form of tablets is easily scattered during transportation.
Many customers try to solve this problem by adding other additives, but this has resulted in larger tablets, which is not the best choice for consumers with a higher target population. Therefore, low-density NMN is only suitable for powder product formulations.
2. Immerse the adulterated NMN ingredients. Unfortunately, the market is flooded with counterfeit and adulterated NMN. Since NMN entered the market last year, many new NMN brands have appeared one after another. It is difficult for manufacturers and our customers to distinguish genuine high-quality materials from counterfeit and low-purity ingredients sold online.
Certain NMN products sold have a purity of less than 80%. Customers and customers just don’t know what fillers or contaminants are in the other 20% of the product.
In fact, we found that many NMN suppliers either sell nicotinamide (common and cheap vitamin B3) or sell nicotinamide ribose instead of NMN. Even more suppliers add flour to dilute NMN and deceive their customers. These products are usually cheap, but they do not have any beneficial effects.
3. Lack of safe and effective data. NMN is becoming more and more popular in the United States, Europe, Japan and China, but still lacks a large amount of safe and effective data. Many people still don’t trust the product, so the market for NMN is always limited. In fact, NMN originally exists in the human body and some vegetables, such as broccoli, so there is no safety issue. But now is the time for further data verification.
In order to determine how to obtain stable, reliable, pure and safe products, a series of tests and analyses were carried out.
By analyzing the structure of NMN and using charge transfer and in-situ FTIR monitoring methods, it is found that NMN has an internal salt structure, and the isoelectric point of the internal salt is a key factor in the instability of NMN. As a polar molecule, water will cause electrical transfer in NMN, thereby destroying the fairly stable internal salt framework of NMN. If so, NMN will show a metastable transition structure that is prone to degradation, that is, the moisture in the product and the free water molecules in the air will directly destroy the isoelectric point of the internal salt and reduce the purity of NMN. This is a major breakthrough in NMN stability research and will be a starting point for improvement.
In order to improve the stability of the internal NMN, the researchers creatively developed a new NMN with a regular and compact micro-arrangement (Figure 2: Length: 3㎛-10㎛), and specially introduced a new generation of high-density NMN . Compared with the sawtooth structure of the first-generation NMN products (Figure 3: Length: 9㎛-25㎛), the second-generation NMN has two incomparable advantages:
Stronger stability and longer shelf life. The spatial arrangement of the new NMN form of NMN is more orderly and compact, effectively preventing contact with free water in the air, thereby greatly improving the stability of NMN and extending the shelf life of the product. Contrary to the novel NMN microstructure, the first-generation zigzag structure shows more disorder and compactness, so each molecule will be more exposed to the air and absorb more water.
The density is higher, the dosage is more stable, and the formula is more flexible. The neatly arranged and compact NMN of the microscope has higher bulk density and fluidity, avoiding the unstable dose caused by dust during the preparation process. In addition, it will affect the uniform dosage of the capsule. At the same time, because the second-generation NMN has better fluidity, it can help shorten the production cycle and reduce the manufacturing cost in the production process.
pH value and water content are properly controlled. In addition, inappropriate acid or alkali conditions will destroy the electrical balance inside the slats, so pH is one of the key factors to improve stability. Dr. Hu of Effepharm initially discovered that the adjustment of pH can control the internal structure of NMN, and his team has established the gold standard of pH that can enhance the internal structure of NMN. In addition, the team controls the water content not less than 1%. If NMN initially retains a small amount of water, the stability will also be greatly improved.
There should be a third-party laboratory test report to verify the identity and purity of NNM. Each batch of raw materials must pass strict self-inspection and third-party testing.
Based on high purity, impurities should be strictly controlled, where the content of individual impurities does not exceed 0.5%, and the content of total impurities does not exceed 1%. All known impurities include NR, nicotinamide, ribose, etc., which have been approved by the FDA as food ingredients. In addition, heavy metals and microorganisms must be strictly controlled in accordance with USP standards within a safe range and can be used with confidence. NMR and LC-MS test reports can further confirm the authenticity, high quality and purity of NMN.
As NMN becomes more and more popular in the United States, Europe, Japan, China and other parts of the world, safety and effectiveness are becoming more and more important. There is still a lack of safety and efficiency data, which limits the growth of NMN in the market. Now is the time to verify the effectiveness of NMN in human clinical trials. This is the direction Effepharm is leading.
Effepharm has initiated a multi-center, randomized, double-blind, concurrent design, placebo-controlled study to evaluate the efficacy and safety of NMN. This is the largest and most comprehensive human clinical trial on NMN to date.
The trial will have 66 subjects and will be completed by the end of 2020. The first part of the animal acute toxicity test has been completed, and the test results show that our Uthever NMN has no acute toxicity. In addition, research on the new function of NMN as a UV protection skin has been completed, and SCI papers and patents will be published soon.
We predict that there will be hundreds of NMN brands next year. After that, everyone will have a price advantage and market share will be limited. Only different selling points can guarantee sales and establish a unique brand image.
Effepharm already has a professional scientific team, and we are the only NMN raw material manufacturer that is undergoing clinical safety and effectiveness trials, which will also bring you a higher brand image. We are also developing new and different functions of NMN, which can enable you to quickly adapt to the changing needs of the fast-growing market.
By choosing Uthever NMN, you can ensure that you get stable, reliable, pure and safe products that customers can trust. We can help you fulfill the promise of this outstanding young man.
The content is provided by Effepharm (Shanghai) Ltd and not written by the NutraIngredients-usa.com editorial team. For more information about this article, please contact Effepharm (Shanghai) Ltd.
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Post time: Nov-07-2020