Recently, scientists at the Malague Medical School in Iran said that according to systematic reviews and meta-analyses of 10 randomized, controlled trials, curcumin extract can improve endothelial function. It is reported that this is the first meta-analysis to evaluate the effects of curcumin supplementation on endothelial function.
Research data published in the Plant Therapy Study suggests that curcumin supplements are associated with a significant increase in blood flow-mediated dilation (FMD). FMD is an indicator of the ability to relax blood vessels. However, no other cardiovascular health indicators were observed, such as pulse wave velocity, augmentation index, endothelin 1 (a potent vasoconstrictor) soluble intercellular adhesion molecule 1 (inflammatory marker sICAM1).
The researchers analyzed the scientific literature and identified 10 studies that met the inclusion criteria. There were a total of 765 participants, 396 in the intervention group and 369 in the control/placebo group. The results showed that supplementation with curcumin was associated with a significant increase in FMD compared to the control group, but no other measurement studies were observed. In evaluating its underlying mechanism of action, the researchers believe that this may be related to the antioxidant and anti-inflammatory effects of the compound. Curcumin exerts anti-inflammatory and anti-oxidative effects by inhibiting the production of inflammatory markers such as tumor necrosis factor, suggesting that its effect on endothelial function may be to inhibit inflammation and/or oxidative damage by down-regulating the level of tumor necrosis factor.
This study provides new evidence for scientific research supporting the potential health benefits of turmeric and curcumin. In some markets around the world, this raw material is experiencing phenomenal growth, especially in the United States. According to the 2018 Herbal Market Report released by the US Plants Board, from 2013 to 2017, turmeric/curcumin supplements have been the best-selling herbal supplements in the US natural channel, but last year’s sales of CBD supplements in this channel surged. And lost this crown. Despite falling to second place, turmeric supplements still reached $51 million in sales in 2018, and mass channel sales reached $93 million.
Post time: Nov-04-2019