Unlock the secret of ginsenoside CK, a new breakthrough in the wave of immunity and health

Immunity is the only solid barrier to the health of the body. The immune system works like an “army” in the body, fighting against the “enemy” that endangers our health every day, but most of the time we don’t feel it. This fierce “battle” is because this “team” has an absolute advantage. Once the immunity is broken, our body will “break down” and a series of diseases will appear, which not only puts pressure on the individual, but also burdens the family. The repetition of the new crown epidemic has further confirmed the importance of human immunity. A number of studies have confirmed that ginsenoside CK has made a major breakthrough in the regulation of human immunity and has successfully made its way out of the health food market.

In China, ginseng has always been regarded as the king of herbs and is known as “the best nourishing and strengthening agent in the East”. In the West, ginseng is called PANAX C.A. MEYERGINSENG, “PANAX” comes from Greek, meaning “to cure all diseases”, and “GINSENG” is the Chinese pronunciation of ginseng. Ginseng is a perennial herbaceous plant belonging to the genus Araliaceae ginseng. The plants of the genus Araliaceae originated from the Cenozoic and Tertiary Period, about 60 million years ago. When the Quaternary Ice Age arrived, their living area was greatly reduced. Ginseng and ginseng Other plants in the genus have also survived as ancient relics. This is also enough to show that ginseng can withstand the test of the environment and the times, and still contributes to human health.
The classical work “Dream of Red Mansions” mentions “Ginseng Yangrong Pill”, which is a nourishing medicine that Lin Daiyu usually takes. Lin Daiyu had just entered Jia Mansion, and everyone seemed to have a deficiency, so they asked her what’s wrong? What kind of medicine? Daiyu smiled and said: “Now I still eat ginseng Yangrong pills.” Insufficiency is a weakened immune system in modern terms, which shows the advantages of ginseng in improving immunity. In addition, “Compendium of Materia Medica” and “Dongyibaojian” also record prescriptions containing ginseng.
In ancient times, ginseng was only enjoyed by emperors and nobles. Now it has rushed out of Asia, forming a “ginseng fever” around the world. More and more researchers and scholars have begun to study ginseng and other derivatives, ginseng extract and ginsenosides ( Ginsenoside) and so on.

Saponins are a kind of glycosides and are composed of sapogenin and sugar, uronic acid or other organic acids. Ginsenosides are the essence of ginseng, and are the main pharmacologically active components of ginseng, panax notoginseng and American ginseng. At present, about 50 ginsenoside monomers have been isolated. The ginsenosides directly extracted in this way are called prototype ginsenosides, including Ra, Rb1, Rb2, Rb3, Re, Rg1, etc. The prototype ginsenosides must be decomposed by specific enzymes and converted into rare ginsenosides before they can be truly absorbed and utilized by the human body. However, the amount of this enzyme in the body is very small, so the body utilization rate of prototype ginsenoside is very low.

Ginsenoside CK (Compound K) is a glycol-type saponin, which belongs to rare ginsenosides. It is almost absent in natural ginseng. It is the main degradation product of other high-content ginsenosides Rb1 and Rg3 in the human intestine. It has high biological activity and high absorption by the human body. As early as 1972, Yasioka et al. discovered ginsenoside CK for the first time. The “natural prodrug” theory also confirmed the biological activity of ginsenoside CK. Many studies have shown that its anti-tumor and immune enhancement activities are the strongest among all ginsenosides.

Since ginsenoside Rg3 entered the market, the response has been unsatisfactory. Many people don’t know that ginsenoside Rg3, which has always been promising, is actually a water- and fat-soluble component that cannot be directly absorbed by the human body, and its utilization rate is very low. Regardless of how much the body consumes, the actual effect is minimal.
In order to overcome this problem, Amicogen’s R&D team has discovered through a large number of experiments that some microorganisms in the human body can convert PPD form ginsenosides into CK form and absorb and utilize them by activating β-glucosaminease. After six years of precipitation research, the team finally successfully developed ginsenoside CK through fermentation, applied for related patent technology, and published related papers. Compared with acid-base hydrolysis method and enzyme conversion method, it has unparalleled advantages in terms of production cost and industrialized mass production. Among them, the content of CK can reach up to 15%, and the conventional specification is 3%. Customized production can be carried out according to demand, and the maximum can be customized 15%. It can be described as a major breakthrough in the research of ginsenosides.

Due to the advent of ginsenoside CK, there are many more research directions and ideas to protect the health of the body, and more corporate R&D personnel will be very interested in its application. Ginsenoside CK not only plays a prominent role in the body’s immune function, but also has a large amount of experimental data to support its anti-cancer, anti-diabetic, neuroprotective, memory improvement and skin health effects. In the future, more products led by ginsenoside CK will enter thousands of households to protect the health of their families.

Post time: Sep-09-2021