We try for excellence, service the customers”, hopes to be the most effective cooperation workforce and dominator company for staff, suppliers and shoppers, realizes price share and ongoing marketing for Smoke Tree Extract Fisetin Powder, We sincerely welcome the two foreign and domestic business enterprise companions, and hope to operate with you in the close to long term!
We try for excellence, service the customers”, hopes to be the most effective cooperation workforce and dominator company for staff, suppliers and shoppers, realizes price share and ongoing marketing for China CAS 528-48-3 and Fisetin Powder, Our company is working by the operation principle of “integrity-based, cooperation created, people oriented, win-win cooperation”. We hope we can have a friendly relationship with businessman from all over the world
Bulk Fisetin Powder
| Product Name | Fisetin bulk powder |
| IUPAC name | 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxychromen-4-one |
| Synonyms | 3,3′,4′,7-tetrahydroxyflavonoid, Cotinin (not to be confused with Cotinine), 7,3′,4′-flavon-3-ol, 5-Deoxyquercetin, Superfustel, Fisetholz, Fietin, Fustel, Fustet, Smoketree extract, wax tree extract, Rhus Succedanea Extract |
| CAS Number | 528-48-3 |
| Molecular Formula | C15H10O6 |
| Molecular Weight | 286.2363 |
| Botanical Source | Cotinus coggygria |
| Specification | 10%-98% Fisetin |
| Appearance | brown-yellow to light yellow |
| Functions | Longevity, brain health |
Fisetin Sources
Fruits and vegetable sources
Fisetin is a natural polyphenolic flavonol which exists in many fruits and vegetables, such as strawberries(16mg),apples(3mg),persimmons(1mg),onions(0.4mg),grapes(0.3mg),kiwi(0.2mg),cucumbers(0.01mg), peaches(0.06mg) etc.
Plant sources
You can find fisetin in a wide variety of plants, naturally extracted from Rhus succedanea. L or wax tree(Toxicodendron succedaneum) or Smoketree (Cotinus coggygria scop.) except fruit and vegetables.
Fisetin bioavailability
Due to poor water solubility and high lipophilicity, fisetin has low oral bioavailability, which limits its further development and clinical application, therefore, high-availability forms of fisetin will bring great promise. Liposomal fisetin powder is popular among our clients in the United States and Europe.
Fisetin Benefits
Fisetin extends longevity
Fisetin’s ability to activate the AMPK pathway, combined with its other biochemical properties, enables this substance to have a senescent cell removal ability comparable to the current mainstream Senolytics drugs (a class of experimental drugs that can target and remove senescent cells).
—-From the Department of Respiratory and Critical care medicine, west China hospital team
Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
–From Matthew J Yousefzadeh
Fisetin anticancer
Fisetin, a polyphenol with pleiotropic pharmacological properties, has been used to inhibit various stages of cancer cells (proliferation, invasion), arrest cell cycle progression, inhibit cell growth, induce apoptosis, induce polymerase ( PARP) cleaves, and regulate the expression of Bcl-2 family proteins in different cancer cell lines (HT-29, U266, MDA-MB-231, BT549, and PC-3M-luc-6). In addition, fisetin inhibited the activation of PKCα/ROS/ERK1/2 and p38 MAPK signaling pathways, decreased NFNF-κB activation, and down-regulated the level of the oncoprotein securin. Fisetin also inhibits cell division, proliferation, and invasion, and reduces TET1 expression levels.
Fisetin inhibits cancer cell stages, arrests the progression of the cell cycle and cell growth, and induces apoptosis, showing promising anticancer activity in cancer.
Fisetin Improve brain Health
Anti-inflammatory and antioxidant effects of fisetin, as well as its effects on regulated cell death-oxygen/ferroptosis pathways, the gut microbiome, and its senescence activity, demonstrate that it modulates a large number of pathways associated with brain dysfunction The ability to effectively prevent Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, stroke (ischemic and hemorrhagic) and traumatic brain injury in preclinical models.
Fisetin applications
Because of its various pharmacological properties, the bioactive flavonol molecule Fisetin demands an increase in dietary supplements, it can combinate many ingredients.
Fisetin+quercetin
Fisetin and quercetin have a similar molecule structure, their potential for biological activity has been established, particularly in regulating a range of cancer signaling pathways. The combined formula promotes cellular health, longevity, healthy aging, improves cognition, and protects cells from stress-related damage.
Fisetin+ resveratrol+NMN Formula
Nicotinamide mononucleotide (NMN), NAD boosters, has beneficial effects on diseases and symptoms of aging. Fisetin seems to be the most potent natural senolytic (R). Resveratrol, the famous anti-aging substance, the combination of the three will become a powerful anti-aging artifact.
Fisetin+ glutathione Formula
Glutathione is the body’s “master antioxidant” and detoxifier for every cell in the body, while Fisetin acts as an antioxidant that increases GSH and helps maintain mitochondrial function in the presence of oxidative stress.
Fisetin+fenugreek
The brand Bio-Fisetin from Life-extension, combinate with galactomannans isolated from herb fenugreek, greatly improved its bioavailability.
Fisetin+Spermidine
the natural polyamine spermidine powder extracted from the wheat germ(Triticum aestivum L) has remarkable benefits to health and longevity. Fisetin+Spermidine supplement stack opens a new avenue in the protection and restoration of memory abilities at a higher age.
Fisetin Manufacturing Process
