Product Name:Black Ginger Extract
Botanic Source:Kaempferia parviflora.L
CAS No:21392-57-4
Other Name:5.7-Dimethoxyflavone
Specifications: 5.7-Dimethoxyflavone ≥2.5%
Total Flavonoids≥10%
Colour: Purple powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
5,7-Dimethoxyflavone is one of the main components of Kaempferia parviflora, which has anti obesity, anti-inflammatory, and anti-tumor effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also an effective anti breast cancer protein (BCRP) inhibitor.
In Vitro Activity:
The best in vitro trypanocidal activity for T. brucei rhodesiense was exerted by 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3′,4′-tetrahydroxyflavone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml).?The activity against T. cruzi was moderate, and only Chrysin dimethylether and 3-hydroxydaidzein had IC50s less than 5.0 microg/ml.
In Vivo Activity:
5,7-Dimethoxyflavone (10 mg/kg, oral, once daily, for 10 days) can reduce the expression levels of CYP3A11 and CYP3A25 proteins in the liver of mice [1].
5,7-Dimethoxyflavone (25 and 50 mg/kg, oral) can inhibit sarcopenia in elderly mice [3].
5,7-Dimethoxyflavone (50 mg/kg/d, oral, lasting for 6 weeks) can reduce weight gain and inhibit fatty liver in HFD mice [5].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
