Black Ginger Extract 5.7-Dimethoxyflavone

Short Description:

Black ginger, a kind of ginger plant, grows in tropical Asia; it is mainly distributed in northeastern Thailand. Scientifically, it is called Kaempferia parviflora, which is commonly referred to as “black turmeric” or “black ginger” in Japan.

  • FOB Price: US $0.5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Payment Terms: L/C,D/A,D/P,T/T
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  • Product Detail

    Product Tags

    Product Name:Black Ginger Extract

    Botanic Source:Kaempferia parviflora.L

    CAS No:21392-57-4

    Other Name:5.7-Dimethoxyflavone

    Specifications: 5.7-Dimethoxyflavone ≥2.5%
    Total Flavonoids≥10%

    Colour: Purple powder with characteristic odor and taste

    GMO Status:GMO Free

    Packing: in 25kgs fiber drums

    Storage:Keep container unopened in cool, dry place,Keep away from strong light

    Shelf Life:24 months from date of production

    5,7-Dimethoxyflavone is one of the main components of Kaempferia parviflora, which has anti obesity, anti-inflammatory, and anti-tumor effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also an effective anti breast cancer protein (BCRP) inhibitor.

    In Vitro Activity:

    The best in vitro trypanocidal activity for T. brucei rhodesiense was exerted by 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3′,4′-tetrahydroxyflavone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml).?The activity against T. cruzi was moderate, and only Chrysin dimethylether and 3-hydroxydaidzein had IC50s less than 5.0 microg/ml.

    In Vivo Activity:

    5,7-Dimethoxyflavone (10 mg/kg, oral, once daily, for 10 days) can reduce the expression levels of CYP3A11 and CYP3A25 proteins in the liver of mice [1].

    5,7-Dimethoxyflavone (25 and 50 mg/kg, oral) can inhibit sarcopenia in elderly mice [3].

    5,7-Dimethoxyflavone (50 mg/kg/d, oral, lasting for 6 weeks) can reduce weight gain and inhibit fatty liver in HFD mice [5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.





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