Product Name:Evodiamine

Other Name:Evodiamine, Isoevodiamine, (+)-Evodiamine, d-Evodiamine,Fructus Evodiae Extract

CAS No:518-17-2

Assay:  98%Min

Colour: Light yellow crystalline powder

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Evodiamine is a unique bioactive alkaloid and the main bioactive ingredient in traditional Chinese medicine. Found in the berries of the Evodia evodia plant, which grows primarily in China and Korea.Evodiamine is a unique bioactive alkaloid and the main bioactive ingredient in traditional Chinese medicine. Found in the berries of the Evodia evodia plant, which grows primarily in China and Korea. This plant is rich in chemical diversity and has been traditionally used in traditional Chinese medicine to treat a variety of health problems, including digestive disorders, inflammation, and pain. Evodiamine works by targeting various molecular pathways in the body. It is known to stimulate the activation of vanillin receptors, which play a crucial role in pain perception and thermogenesis. Additionally, it has been found to interact with serotonin and dopamine receptors, suggesting that it has potential mood-enhancing properties.

Biological activity: Evodiamine is an alkaloid isolated from the fruit of Bentham, which has various biological activities such as anti-inflammatory, anti obesity, and anti-tumor. In vitro: Evodiamine has shown cytotoxicity against various human cancer cell lines by inducing apoptosis. In addition, it is a natural multi-target anti-tumor molecule that exerts anti-tumor activity through various molecular mechanisms such as caspase dependent and non dependent pathways, sphingomyelin pathway, calcium/JNK signaling, 31 PI3K/Akt/caspase, and Fas-L/. NF – κ B signaling pathway 32 [1]. In vivo: Evodiamine inhibits the metabolism of dapoxetine. Compared with the control group, the t1/2, AUC (0- ∞), and Tmax pharmacokinetic parameters of dapoxetine in the evodiamine group were significantly increased by 63.3%, 44.8%, and 50.4%, respectively. In addition, evodiamine significantly reduced the t1/2 pharmacokinetic parameters and AUC (0- ∞) of demethylated dapoxetine [2]. Evodiamine inhibits tumor growth in subcutaneous H22 xenograft model. Evodiamine attenuates VEGF induced angiogenesis in vivo.

In vitro: Evodiamine exhibits cytotoxicity against various human cancer cell lines by inducing apoptosis. In addition, it is a natural multi-target anti-tumor molecule that exerts anti-tumor activity through various molecular mechanisms such as caspase dependent and non dependent pathways, sphingomyelin pathway, calcium/JNK signaling, 31 PI3K/Akt/caspase, and Fas-L/. NF – κ B signaling pathway 32 [1].

In vivo: Evodiamine inhibits the metabolism of dapoxetine. Compared with the control group, the t1/2, AUC (0- ∞), and Tmax pharmacokinetic parameters of dapoxetine in the evodiamine group were significantly increased by 63.3%, 44.8%, and 50.4%, respectively. In addition, evodiamine significantly reduced the t1/2 pharmacokinetic parameters and AUC (0- ∞) of demethylated dapoxetine [2]. Evodiamine inhibits tumor growth in subcutaneous H22 xenograft model. Evodiamine attenuates VEGF induced angiogenesis in vivo.

FUNCTION:

Anti inflammatory, anti-tumor, and hypoglycemic activities have certain therapeutic effects on the treatment of early senile dementia and stroke.It has analgesic, lowers blood pressure and induces a significant rise of body temperature effects. The clinical utility of this product is to produce medical agents for diuretics and sweat.

1. Evodia extract is used to treat symptoms of abdominal distress. These include nausea, vomiting, and diarrhea. It is said to be especially effective in treating morning diarrhea.

2. Evodia is used to stimulate the appetite and to treat abdominal symptoms associated with lack of interest in food.

3. Evodia extract also has anti-inflammatory, anti-tumor, anti-viral, astringent, and diuretic properties.

4. Evodiamine with analgesia, lowering blood pressure and body temperature rise and other pharmacological effects.

5. Evodiamine has stomachic, stop retching, oxyrygmia effect anddiuretic effect.

6.Evodiamine has a strong inhibitory effect on li; and a significant insecticidal effect on ascarissuum;

7.Evodiamine also can shrink the uterus and boost the pressure.

8.Besides,evodiamine also has a good effect on Alzheimer’s disease and stroke.

Application: