Product Name:Galantamine Hydrobromide

Other Name: Galanthamine hydrobromide;Galantamine HBr; Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,Hydrobromide

CAS NO：1953-04-4

Specifications: 98.0%

Colour:White powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Galantamine is used for the treatment of mild to moderate Alzheimer’s disease and various other memory impairments, particularly those of vascular origin. It is an alkaloid that is obtained synthetically or from the bulbs and flowers of Galanthus Caucasicus (Caucasian snowdrop, Voronov’s snowdrop), Galanthus woronowii (Amaryllidaceae) and related genera like Narcissus (daffodil)), Leucojum(snowflake) and Lycoris including Lycoris radiata (Red Spider Lily).

Galanthamine is natural extracted from lycoris radiate,is a tertiary alkaloid derived from snow drop and closely related species. It acts as a reversible competitive acetylcholinesterase (ACHE) inhibitor, while acts weaker on butyrylcholinesterse(BuChE).it is used in the treatment of disorders of the central nerbous system and may be used as an antidote to nonpolarizing muscle relaxants.Galanthamine hydrobromide is a white to almost white powder; sparingly soluble in water; insoluble chloroform, ether and alcohol .

Galantamine hydrobromide is a benzazepine derived from the bulbs and flowers of narcissus, osmanthus, or canna. It is also an oral cholinesterase inhibitor. As a ligand for nicotinic acetylcholine receptors, it has been widely used to enhance neurocognitive function. Its function is to competitively and reversibly inhibit acetylcholinesterase, thereby increasing the concentration of acetylcholine. When absorbed into the bloodstream, galantamine hydrobromide is readily absorbed into various parts of the body, including the brain. It binds to nicotinic acetylcholine receptors, causing conformational changes and increasing acetylcholine release. It also works by competing with and reversing the effects of cholinesterase inhibitors. By inhibiting cholinesterase, it prevents the breakdown of acetylcholine, thereby increasing the levels and duration of this powerful neurotransmitter. Galantamine may also improve learning and memory, prevent brain inflammation, and maintain high levels of neurotransmitters by maintaining the integrity of neurons and synapses

Function:

(1) Anti-cholinesterase .

(2) Stimulate and inhibit acetylcholinesterase, regulate intracephalic nicotine receptor position.

(3) Cures the infantile paralysis sequelae, sweeny and myasthenia gravis pseudoparalytica, etc.

(4) Improve the recognition function of light, mild Alzheimer disease patients significantly, and delay the process of function decrease of brain cells.

(5) Improve the conduction between nerve and muscle.

Application
1. Galanthamine Hydrobromide is mainly used in myasthenia gravis, poliovirus quiescent stage and sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous system disease or traumatism;

2. Galanthamine Hydrobromide is also used in Alzheimer’s disease, has the principal function for dement and dysmnesia caused by organic brain damage.