Ursodeoxycholic acid ntụ ntụ

Onyonyo egosipụtara Ursodeoxycholic Acid ntụ ntụ
  • Ursodeoxycholic acid ntụ ntụ

Nkọwa dị mkpirikpi:

Ursodeoxycholic acid (UDCA), nke a makwaara dị ka ursodiol, bụ bile acid nke na-eme n'okike nke mebere obere akụkụ nke ọdọ mmiri bile acid mmadụ. A na-eji UDCA agwọ ọrịa imeju ruo ọtụtụ iri afọ: ojiji mbụ ya na ọgwụ ọdịnala malitere ihe karịrị otu narị afọ.

Ursodeoxycholic acid ntụ ntụ bụ 99% dị ọcha bile acid nke a na-ahụkarị na bea jikọtara ya na taurine. Aha kemịkal ya bụ 3a,7 β-dihydroxy-5 β-Golestan-24-acid. Ọ bụ ngwakọta organic na-enweghị isi, ụtọ ilu.

Ursodeoxycholic acid bụ ọgwụ a na-eji na njikwa na ọgwụgwọ ọrịa imeju cholestatic. Ọrụ a na-enyocha ihe ngosi, usoro ihe omume, na contraindications maka UDCA dị ka onye na-ahụ maka ọrụ bara uru na njikwa ọrịa imeju.


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    Nkọwa ngwaahịa

    Mkpado ngwaahịa

    Aha ngwaahịa: Ursodeoxycholic acid ntụ ntụ

    Aha ndị ọzọ: nnukwu Ursodeoxycholic acid ntụ ntụ (UDCA)Ursodiol; UDCA; (3a,5b,7b,8x) -3,7-dihydroxycholan-24-oic acid; Ursofalk; Actigall; Urso

    CAS Mba:128-13-2

    Nyocha: 99% ~ 101%

    Agba: Gbanyụọ ọcha ka ọ bụrụ ntụ ntụ edo edo na-acha odo odo

    Solubility: soluble na mmiri, kpamkpam soluble na ethyl mmanya

    Ọnọdụ GMO: GMO efu

    Mbukota: na 25kgs fiber drum

    Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

    Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta

    Ursodeoxycholic acid ntụ ntụ(CAS 128-13-2) - Ọdịcha ọgwụ na nyocha nyocha

    Nchịkọta ngwaahịa

    Ursodeoxycholic acid (UDCA), makwaara dị ka Ursodiol, bụ hydrophilic secondary bile acid na ịdị ọcha nke ≥99%. A na-emepụta ya site na cholic acid site na usoro kemịkalụ na usoro enzymatic dị elu, na-eme ka stereoselectivity dị elu na nkwado gburugburu ebe obibi. A na-eji ntụ ntụ kristal na-acha ọcha eme ihe n'ọtụtụ ebe na nyocha ọgwụ na ngwa ọgwụgwọ n'ihi cytoprotective, mgbochi apoptotic, na ihe na-ebelata cholesterol.

    Nkọwapụta igodo

    • Nọmba CAS: 128-13-2
    • Ụdị mkpụrụ ndụ: C₂₄H₄₀O₄
    • Arọ Molecular: 392.57 g/mol
    • Ebe mgbaze: 203–204°C
    • Nchekwa: Chekwaa na -20C n'ebe kpọrọ nkụ, gbara ọchịchịrị.

    Usoro nke Omume

    UDCA na-arụ ọtụtụ mmetụta ọgwụgwọ:

    1. Nchedo imeju: na-eme ka mmiri bile dịkwuo mma, na-ebelata saturation cholesterol na bile, na-eme ka akpụkpọ anụ hepatocyte kwụsie ike.
    2. Mgbochi FATP5: Na-arụ ọrụ dị ka onye na-egbochi protein 5 (FATP5) fatty acid fatty acid, na-emezi metabolism lipid.
    3. Immunomodulation: Na-egbochi nrụgide oxidative na ụzọ mkpali (dịka, NF-κB, Erk).
    4. Mgbasa Gallstone: Na-ebelata nnabata cholesterol ma na-agbaze gallstones cholesterol site na nnọchi bile acid.

    Ngwa

    1. Ọrịa imeju

    • Primary Biliary Cholangitis (PBC): Na-eme ka ọkwa enzyme imeju dịkwuo mma (dịka ọmụmaatụ, alkaline phosphatase) ma na-egbu oge ọganihu ọrịa.
    • Ọrịa imeju na-adịghị egbu egbu (NAFLD): Na-ebelata mkpokọta lipid imeju.
    • Ọrịa Cholestatic: ejiri ya nke ọma na cholestasis intrahepatic nke afọ ime na dose nke 10-25 mg / kg / ụbọchị.

    2. Nchịkwa Gallstone

    • Dị irè maka cholesterol gallstones na ndị ọrịa na-adịghị mma maka ịwa ahụ.

    3. Nnyocha na-apụta

    • COVID-19: Ọrụ nwere ike na mbenata okwu nnabata ACE2, na-egbochi ntinye nje.
    • Cardioprotection: Achọpụtara maka mgbochi arrhythmic na mgbochi fibrotic mmetụta.

    Nchekwa na njikwa

    • Okwu egwu: na-ebute mgbakasị anya na anụ ahụ (ụdị 2) .
    • Akpachara anya:Ọnọdụ nchịkwa: maka naanị nyocha. Ekwetaghị maka ọgwụgwọ mmadụ ma ọ bụ ọgwụgwọ anụmanụ.
      • Jiri ngwa nchedo onwe onye (gloves, goggles).
      • Zere iku ume ma ọ bụ kọntaktị ozugbo.

    Nkwakọ ngwaahịa na ịtụ

    • Ọnụ ọgụgụ dị: 1 g, 10 g, 100 g.
    • Nkwakọ ngwaahịa omenala: nnukwu iwu dị mgbe a rịọrọ ya.
    • Nnweta COA: Asambodo akọwapụtara nke ọma nyere n'usoro ọ bụla.

    Kedu ihe kpatara ịhọrọ ntụ ntụ UDCA anyị?

    • Ịdị ọcha dị elu: QC siri ike na-eme ka ≥99% ịdị ọcha site na nyocha HPLC.
    • Nkwado nyocha: akwụkwọ nka na ụzụ na usoro njikọ dị.
    • Nkwekọrịta zuru ụwa ọnụ: zutere ụkpụrụ ISO na GMP maka ndị n'etiti ọgwụ.

    Keywords: Ursodeoxycholic Acid ntụ ntụ, CAS 128-13-2, FATP5 Inhibitor, Cholesterol Gallstones, Nchekwa imeju, ≥99% Ọcha

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