J-147 ntụ ntụ

Oyiyi egosipụtara ntụ ntụ J-147
  • J-147 ntụ ntụ

Nkọwa dị mkpirikpi:

J147 bụ J-147 bụ ihe pụrụ iche nwere ike, ọnụ na-arụsi ọrụ ike na nke ukwuu neuroprotective compound nwere ike welie ebe nchekwa na nkịtị anụmanụ yana igbochi ebe nchekwa deficits na ọrịa Alzheimer (AD) transgenic ụmụ oke. A na-ejikọta ọrụ neurotrophic na ebe nchekwa nchekwa nke J-147 na mmụba nke ụbụrụ na-enweta ụbụrụ neurotrophic (BDNF) na nkwupụta nke protein na-anabata BDNF, nkwalite nke LTP, nchekwa nke protein synaptic, mbelata amyloid plaques.

J-147 bụ neuroprotectant na-arụ ọrụ nke ọma nke sitere na curcumin, ihe na-arụ ọrụ na turmeric. N'adịghị ka curcumin, ọ na-agafe ihe mgbochi ụbụrụ ọbara nke ọma.

J-147 bụ neuroprotectant na-arụ ọrụ nke ọma nke sitere na curcumin, ihe na-arụ ọrụ na turmeric. N'adịghị ka curcumin, ọ na-agafe ihe mgbochi ụbụrụ ọbara nke ọma. N'ime ha, J-147 na-arụ ọrụ site na ijikọ ATP synthase. Mmepụta nke ATP na-ejikọta ya na usoro ịka nká. Na mgbakwunye na ịbawanye ọkwa nke neurotransmitters NGF na BDNF, J-147 nwere ike ịchịkwa nke a. Na mgbakwunye, J-147 na-egbochi monoamine oxidase B na dopamine transporter. Na-akwalite uto ụbụrụ site n'ịbawanye ọkwa nke ihe na-eto eto (NGF) na ụbụrụ neurotrophic factor (BDNF). Nke kachasị mkpa, J-147 nwere ike ịkwalite uto nke mkpụrụ ndụ akwara ọhụrụ, kwalite ikike mmụta na ebe nchekwa ụbụrụ, ma melite ọrụ ọgụgụ isi.


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    Nkọwa ngwaahịa

    Mkpado ngwaahịa

    Aha ngwaahịa:J-147 ntụ ntụ

    Aha ọzọ:2,2,2-Trifluoroacetic acid 1- (2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl) Methylene] hydrazide],J-147, J147

    CAS Mba:1146963-51-0

    Nyocha: 99.0% nkeji

    Agba: White ntụ ntụ

    Nkwakọ ngwaahịa: 25kgs Drum

    Aha:J-147 ntụ ntụ: Neuroprotective Agent maka Alzheimer's Research & Anti-Aging Applications
    Nkọwa Meta: Chọpụta J-147 Powder, curcumin na-enweta neuroprotective na-arụ ọrụ nke ọma n'ịkwalite cognition, na-agafe ihe mgbochi ụbụrụ ọbara, na ịchọta ọrịa Alzheimer. Dị n'ọtụtụ nkọwa na mbupu zuru ụwa ọnụ.

    Isi ihe ngwaahịa

    1. Ụlọ ike Neuroprotective
      • Ngwakọta na-arụ ọrụ ọnụ na-egbochi MAO-B (EC50 = 1.88 μM) na onye na-ebugharị dopamine (EC50 = 0.649 μM)
      • Na-akwalite njupụta spine dendritic na ebe nchekwa n'ime ụmụ oke dị ọnwa 6 na ntinye nri 200ppm
      • Nnwale nke ụlọ ọgwụ nwalere nke mbụ maka Alzheimer site na Abrexa Pharmaceuticals & ụlọ ọrụ ndị isi.
    2. Multi-Target Anti-Aging Mechanism
      • Na-ejikọta na ATP synthase iji mezie ọrụ mitochondrial
      • Na-abawanye NGF/BDNF neurotransmitters ka ọ na-egbochi mmebi ụbụrụ ụbụrụ
      • Na-edozi ịka nká vaskụla site na igbochi ntapu microvascular na ụbụrụ òké
    3. Nkọwa nka nka
      • Nọmba CAS: 1146963-51-0 | Ụdị ihe omimi: C18H17F3N2O2
      • Ịdị ọcha: >99% | Solubility: 10 mM na DMSO
      • Nha dị: 1mg-500mg nnukwu iwu | 10mM/1ml ngwọta

    Ntuziaka:

    1. Mmekọrịta okwu
      • Nke mbụ: “Mgbakwunye neuroprotective”, “Ogige nyocha nke Alzheimer”, “curcumin derivative powder”
      • Ogologo ọdụ: "MAO-B inhibitor maka nkwalite ọgụgụ isi", "nkwado mitochondrial mgbochi ịka nká"
    2. Nrube isi SEO teknụzụ
      • Akara data ahaziri maka akụrụngwa kemịkalụ (CAS, EC50, arọ molecular)
      • Njikọ aka na ibe ngwaahịa ndị emetụtara (dịka ọmụmaatụ, CAD-31 usoro, TrkB agonists)
    3. Onye ọrụ-Centric Nhazi
      • Ntugharị ụdị Amazon: Nhazi akụkụ akaekpe + ogwe ọchụchọ kacha elu
      • Tebụlụ ntụnyere mmekọrịta yana ndị asọmpi MCE/TargetMol

    Ihe Ndị Na-ewulite ntụkwasị obi

    • Global Logistics: Nzipu otu ụbọchị (ngwaahịa China) + Mbupu na-achịkwa okpomọkụ
    • Nkwado nyocha: Ụlọ ọrụ Salk kwuru, Blanchette Rockefeller Neurosci Inst
    • Profaịlụ nchekwa: Ọ nweghị genotoxicity hụrụ ruo 90μM na nyocha CeeTox
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