Lupeol Powder 98%
|Product Name||Lupeol bulk powder|
|Synonyms||(3β,13ξ)-Lup-20(29)-en-3-ol; Clerodol; Monogynol B; Fagarasterol; Farganasterol|
|Botanical Source||Mango, Acacia visco, Abronia villosa, Dandelion coffee.|
|Appearance||White to Off-white powder|
|Functions||antimicrobial, antiinflammatory, antitumor|
Lupeol powder is a new dietary triterpene that is both anti-inflammatory and cancer-fighting. Lupeol is a brand-new androgen receptor blocker with anti-inflammatory and antioxidant effects. Through TNF-alpha and VEGFR-2 down-regulation, lupeol has been shown to have anti-angiogenic and cancer-preventing effects. As an anti-inflammatory agent, lupeol functions predominantly in the interleukin system.
Lupeol is found in various plants, including mangoes, acacia, and buttercups. It’s also found in dandelion coffee. Cerpitonol is the main ingredient in mountain tea.
99% Lupeol powder HPLC
Shipment： Shipping by FedEx, DHL, by air or by sea
Package: Plastic bag inside, 1kg/bag, 25kg/drum
Different preclinical and in vitro studies conducted in animals suggest the potential of Lupeol as an antimicrobial, anti-inflammatory, anti-invasive, anti-proliferative, anti-protozoal, anti-angiogenic, and also a cholesterol-lowering agent. Apart from undertaking different in vivo and in vitro studies on Lupeol, scientists have also studied the medicinal efficacy of this natural compound for treating other conditions such as diabetes, renal diseases, cardiovascular diseases, arthritis, and even wound healing. Lupeol has potent antioxidant, anti-inflammatory, anti-arthritic, anti-mutagenic, and antimalarial activities in both in vitro and in vivo systems; acts as a potent inhibitor of protein kinase and serine proteases; and inhibits DNA topoisomerase II, which is a known target of anticancer chemotherapy (9-11). The anti-inflammatory, antioxidant, and antifungal effects of lupeol have also been shown to be due to its ability to downregulate TNF-alpha and VEGF-2.
In recent decades, numerous studies confirmed the substantial anticancer role of lupeol on different cancer cell lines and models (Chaturvedi et al., 2008; Saleem, 2009; Siddique & Saleem, 2011). In addition, anticancer activities of Lupeol (LUP) have been demonstrated in different malignancies, such as colorectal, lung, and liver cancers [18 20 ]. Recent studies investigating the efficacy of LUP for treating various types of cancers (i.e., lung, liver, pancreas, head, and neck) provide valuable insights into the molecular mechanisms behind its anticancer properties [29 32 ]. From the treatment perspective, recent studies of Lupeol (LUP) pharmacological properties have suggested a wide range of biological effects, such as antioxidant, anti-inflammatory, antimicrobial, and dermal protection
The studies of Hata et al., who showed that Lupeol potently suppressed migration of human neuroblastoma and lung adenocarcinoma cells, further strengthened the conviction that Lupeol can be developed as a broad-based anticancer agent. We provided evidence for the anti-CRC effects of Lupeol on cell viability, apoptosis, migration, cell cycle arrest, and the inactivation of the signaling activity of Wnt-b-catenin via b-catenin nuclear translocation. The demonstration is supported by the recent study of Prasad et al.. They showed that Lupeol induces G2/M cell-cycle arrest in tumor cells by inhibiting the signaling pathway that regulates cyclins.
Lupeol showed antifungal activities against Fusarium oxysporum and Penicillium notatum, while acetyl lupeol was inactive. Of ten isolated compounds, lupeol acetate (2) showed the highest antifungal effect on M. phaseolina, with a 79%-81% decrease, followed by betulin (3), with a 77%-79% decrease of biomass in M. phaseolina respectively. Compounds, i.e., lupeol (1), B-sitosterol (4), kaempferol (9), and quercetin (10), were comparably less antifungal and reduced the biomass of the fungal growth by 40-43%, 57-64%, 46-53%, and 47-55%, respectively, than respective controls.
Lupeol has potent antioxidant, anti-inflammatory, antiarthritic, antimutagenic, and antimalarial activities in both in vitro and in vivo systems; it acts as a potent inhibitor of protein kinase and serine protease; and it inhibits DNA topoisomerase II, which is a known target for anticancer chemotherapy (9-11). Lupeol acetate markedly decreased the symptoms of rheumatologic arthritis by suppressing the inflammatory cytokine expression. Lupeol decreases the IL-4 (Interleukin 4-) production of T-helper type 2 cells. Lupeol treatment of cells was found to result in significant decreases in PI3K (p85) protein regulatory subunits expression (Figure 5).
A study from 1998 found Lupeol reduced the swelling in paws in rats by 39%, compared with 35% with the standardized control compound indomethacin. Lupeol has been seen as an active component in several medicinal plants used by indigenous peoples to treat various skin disorders in North America, Japan, China, Latin America, and the Caribbean islands (ref. Chemical modification of lupeol may not only change the biological activities of obtained derivatives, but may improve their bioavailability and efficacy. A proprietary extract from the seed of Lupin was specifically synthesized to produce the ester known as lupeol, a pharmacologically active pentacyclic triterpene.
Lupeol side effects
In an in vivo study using a nude orthotopic model of metastatic oral tongue Squamous Cell Carcinoma, lupeol, in doses of 2 mg/animal, significantly decreased the tumor volume and suppressed local metastasis more effectively than cisplatin alone. Wound healing using a cream of lupeol efficiently enhanced healing in hyperglycemic rats via anti-inflammatory effects via the NF-kB signaling pathway, suggested by decreased levels of mediators associated with inflammation, such as IL-6 (proinflammatory cytokine) and increased levels of IL-10 (anti-inflammatory cytokine).
Low doses of lupeol are desirable as they could minimize toxicity to normal cells and immune suppression effects of lupeol provided the anti-tumor effects can be achieved as well. High doses of lupeol may also suppress anti-tumor immune responses. The most intriguing discovery of the present research was that after three months, ordinary human melanocytes were unaffected by a dosage where Lupeol killed malignant melanoma cells. Our previous results showed that Lupeol could also decrease cell viability in normal human liver cells with IC 50 of 90 mmol/L, suggesting that Lupeol may have toxic effects on normal cells.