Quercetin 95.0%

Quercetin is a type of flavonoid antioxidant that’s found in plant foods, including leafy greens, tomatoes, berries and broccoli. It’s technically considered a “plant pigment,” which is exactly why it’s found in deeply colored, nutrient-packed fruits and veggies.
Considered one of the most abundant antioxidants in the human diet, quercetin plays an important part in fighting free radical damage, the effects of aging and inflammation. While you can get plenty of quercetin from eating a healthy diet, some people also take quercetin supplements for their strong anti-inflammatory effects.

According to the Department of Pathology and Diagnostics at the University of Verona in Italy, quercetin and other flavonoids are “anti-viral, anti-microbial, anti-inflammatory and anti-allergic agents” with potential to be expressed positively in different cell types in both animals and humans. Flavonoid polyphenols are most beneficial for down-regulating or suppressing inflammatory pathways and functions. Quercetin is considered the most diffused and known nature-derived flavonol there is, showing strong effects on immunity and inflammation caused by leukocytes and other intracellular signals.

Quercetin is a potent antioxidant and has anti-inflammatory activity, protecting cellular structures and blood vessels from the damaging effects of free radicals. It improves blood vessel strength. Quercetin inhibits the activity of catechol-O-methyltransferase that breaks down the neurotransmitter norepinephrine. This effect may lead to elevated levels of norepinephrine and an increase in energy expenditure and fat oxidation. It also means quercetin acts as an antihistamine leading to relief of allergies and asthma. As an antioxidant, it reduces LDL cholesterol and offers protection from heart disease. Quercetin blocks an enzyme that leads to accumulation of sorbitol, which has been linked to nerve, eye, and kidney damage in diabetics.

Quercetin can significantly inhibit the effect of cancer-promoting agent, inhibiting the growth of malignant cells in vitro, inhibiting the DNA, RNA, and protein synthesis of Ehrlich ascites tumor cells.
Quercetin has effects of inhibiting the platelet aggregation and the release effect of serotonin (5-HT) as well as inhibiting the platelet aggregation process which is induced by ADP, thrombin and platelet-activating factor (PAF) in which having the strongest inhibition effect on PAF. Moreover, it can also inhibit thrombin-induced the release of platelet 3H-5-HT of rabbit.
(1) Intravenously adding 0.5mmol/L quercetin (10ml/kg) drop wise can significantly shorten the duration of arrhythmia in mice of myocardial ischemia and reperfusion, reduce the incidence of ventricular fibrillation, and reduce the content of MDA as well as the activity of xanthine oxidase inside the ischemic myocardial tissue while having significantly protective effect on SOD. This may be related to the inhibition of the formation process of myocardial oxygen free radical and protection of SOD or directly scavenging of radical free oxygen in myocardial tissue.
(2) Having in vitro assay with quercetin and rutin being together can disperse the platelet and thrombus adhered to the rabbit aorta endothelium with an EC50 of 80 and 500nmol/L, respectivly. In vitro assay of a concentration of quercetin at 50~500μmol/L has shown that it can improve cAMP level inside human platelet, enhance the PGI2-induced improvement of cAMP level of human platelet and inhibit the ADP-induced platelet aggregation. Quercetin at a concentration ranged from 2~50μmol/L has a concentration-dependent enhancement effect. Quercetin, at a concentration of 300 μmol/L in vitro can not only almost completely inhibit the process of platelet aggregation induced by platelet-activating factor (PAF), but also inhibit thrombin and ADP-induced platelet aggregation as well as inhibit the release of rabbit platelet 3H-5HT induced by thrombin; A concentration of 30 μmol/L can significantly reduce the liquidity of platelet membrane.
(3) Quercetin, at a concentration at 4×10-5~1×10-1g/ml, has a inhibitory effect on the release of histamine and SRS-A in the lung of ovalbumin-sensitized guinea pig lung; A concentration of 1 × 10-5g/ml also has inhibitory effect on the for SRS-A induced ileum contraction of guinea pig. Quercetin, at a concentration of 5~50μmol/L, has a concentration-dependent inhibitory effect on the process of histamine release of human basophilic leucocyte. Its inhibitory effect on the ileum contraction of ovalbumin sensitized guinea pig is also concentration-dependent with an IC50 of 10μmol/L. A concentration in the range of 5×10-6~5×10-5mol L can inhibit the proliferation of cytotoxic T lymphocyte (CTL) as well as inhibit ConA-induced DNA synthesis.

Product Name:Quercetin 95.0%

Botanical Source:Sophora japonica extract

Part: Seed(Dried, 100% Natural)
Extraction Method: Water/ Grain Alcohol
Form:Yellow to green yellow crystalline powder
Specification: 95%

Test Method : HPLC

CAS Number: 117-39-5

Molecular Formula:C15H10O7
Molecular Weight: 302.24
GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Function:

1. It has good effect of expectorant, antitussive and antiasthmatic.

2. Decreasing blood pressure and blood fat.
3. Enhancing the resistance of the capillaries and reducing fragility of capillary.
4. Expanding coronary arteries and increasing coronary blood flow and so on.
5. Mainly used in the treatment of chronic bronchitis and it also has the role of adjuvant therapy.

Application:

1. Quercetin may expel phlegm and arrest coughing, it can also be used as anti-asthmatic.
   2.Quercetin has anticancer activity, inhibits PI3-kinase activity and slightly inhibits PIP Kinase activity, reduces cancer cell growth via type II estrogen receptors.
   3.Quercetin may inhibit histamine release from basophils and mast cells.
   4.Quercetin may control the spread of certain viruses within the body. 5, Quercetin may help reduce tissue destruction.
   6.Quercetin may also be beneficial in the treatment of dysentery, gout, and psoriasis