Product Name:7,8-Dihydroxyflavone
Nhamba yeCAS:38183-03-87
Rimwe Zita:7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;
DIHYDROXYFLAVONE, 7,8-(RG);7,8-Dihydroxyflavone hydrate;
7,8-dihydroxy-2-phenyl-1-benzopyran-4-imwe,8-Dihydroxyflavone (7,8-DHF)
Zvinodiwa: 98.0%
Ruvara: Yellow powder ine unhu hwema uye kuravira
GMO Mamiriro:GMO Yemahara
Kurongedza: mune 25kgs fiber zvigubhu
Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba
Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa
Chigadzirwa Tsananguro: 7,8-Dihydroxyflavone (7,8-DHF)- A Multifaceted Compound yeNeuroprotection uye Cognitive Enhancement
Overview
7,8-Dihydroxyflavone (7,8-DHF), flavonoid inogaroitika inowanikwa muzvirimwa zvakaita seTridax procumbensuyeGodmania aesculifolia, chinhu chakasiyana-siyana chebioactive compound ine maitiro maviri ekuita. Inoshanda seyakasarudzwa TrkB receptor agonist (kutevedzera uropi-yakatorwa neurotrophic factor, BDNF) uye inokwikwidza inhibitor yepyridoxal phosphatase (PDXP). Izvi zvivakwa zvinoita kuti ive inovimbisa mumiriri wekutsvagisa tsinga, kuvandudza kwekuziva, uye kurapa kwekushandisa.
Key Features
- Molecular Profile
- Mushonga weKemikari: C₁₅H₁₀O₄
- Nhamba yeCAS:38183-03-8
- Molecular Weight: 254.24 g/mol
- Kuchena: ≥98% (HPLC yakasimbiswa)
- Solubility:
- Yakanyanya soluble muDMSO (kusvika 100 mM) uye ethanol (25 mM)
- Zvishoma soluble mumvura (<1 mg/mL).
- Kuchengeta & Kubata
- Upfu: Chengetedza pa -20 ° C munzvimbo yakashongedzwa (yakagadzikana kwemakore matatu).
- Mhinduro: Aliquot uye chengetedza pa -80 ° C (yakagadzikana kwemakore 1-2).
- Kuchengetedza:
- Shandisa magirovhosi ekudzivirira, gogi, uye majasi erabhoritari.
- Dzivisa inhalation, kupinza, kana kubata ganda rakananga.
- Tevedzera GHS njodzi kupatsanurwa (acute toxicity, kushatirwa kweziso/ganda).
Maitiro Ekuita
- TrkB Receptor Agonism
- Inosungira kuTrkB ine hukama hwepamusoro (Kd ≈ 320 nM), ichimisikidza nzira dzepasi (PI3K/Akt, MAPK) kusimudzira:
- Neurogenesis uye synaptic plastiki.
- Neuroprotection kurwisa oxidative kusagadzikana, excitotoxicity, uye apoptosis.
- Kuwedzeredzwa kwekuziva mumhando dzechirwere cheAlzheimer, kukuvara kwehuropi, uye kuora mwoyo.
- PDXP Inhibition
- Nemakwikwi inhibits pyridoxal phosphatase (PDXP), kuwedzera pyridoxal 5'-phosphate (PLP), iyo inoshanda fomu yevhitamini B5.
- Benefits:
- Inodzosera zera-inotsamira PLP kuderera muhippocampus.
- Inovandudza kudzidza uye ndangariro mune preclinical modhi.
- Kuwedzera Migumisiro
- Antioxidant Activity: Inodzvinyirira nzira dzeJNK / NF-κB kuderedza kuzvimba.
- Metabolic Regulation: Inosimudzira kukwira kweglucose uye inoderedza mazinga eglucose eropa.
Applications
- Neurological Research
- Dzidza neuroprotection muAlzheimer's, Parkinson's, uye ischemic sitiroko modhi.
- Ongorora BDNF/TrkB kusaina mu synaptic plasticity uye kusagadzikana kwepfungwa.
- Cognitive Health Supplements
- Inogona kushandiswa mu nootropics yekusimudzira ndangariro uye neuroplasticity.
- Therapeutic Development
- Ongorora nzira mbiri-dzinovavarira (TrkB + PDXP) yekushaikwa kwevhitamini B6-inoenderana nekudzikira kwekuziva.
Safety & Dosage
- Toxicity: Zvidzidzo zvepreclinical zvinoratidza kusakosha kwakakosha pamishonga yekurapa.
- Inokurudzirwa Dosage (tsvakurudzo inoshandiswa chete):
- In vitro: 250 nM–10 µM.
- In vivo (mbeva): 50-100 mg / kg / zuva nemuromo kana kuburikidza nejekiseni re intraperitoneal.
Sei Sarudza 7,8-DHF?
- Dual-Action Profile: Inosanganisa TrkB activation uye PDXP inhibition kune akawanda mabhenefiti.
- Ropa-Brain Barriers Kupinda: Inoshanda mukati mepakati tsinga system yakanangana.
- Tsvagiridzo-Yakatsigirwa: Yakagadziriswa mune anopfuura makumi mashanu ekutanga zvidzidzo zveuroprotection, cognitive kusimudzira, uye metabolic regulation.
Keywords:TrkB agonist, PDXP inhibitor, neuroprotective agent, cognitive enhancer, flavonoid mabhenefiti, 7,8-DHF solubility, tsvagiridzo yeAlzheimer, BDNF kutevedzera..
