CMS121

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  • CMS121

Tsanangudzo Pfupi

CMS121, yakasarudzika yakasarudzika yefisetin, kemikari inowanikwa mumichero nemiriwo, inovandudza ndangariro, uye inononoka neurodegeneration mumakonzo echirwere cheAlzheimer.

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol musanganiswa unonziwo CMS121. Kurongeka kwekomboni yacho kunoratidza kuti inogona kunge iine zvimiro zvakasiyana uye zvinogona kushandiswa. Kuti unzwisise kukosha kwayo, zvinobatsira kuona mapoka anoshanda aripo uye kuongorora maitiro avo

CMS121 inotsiviwa quin oline ine neuroprotective, anti-inflammatory, antioxidative, uye renoprotective zviitiko. Iyo inochengetedza glutathione (GSH) mazinga muHT22 mbeva hippocampal masero mu vitro muhupo hwe glutamate, induces kusiyanisa kwePC12 masero, inodzivirira LPS-induced N9 microglial activation ne82% muN9 microglia, uye scavenges mahara radicals muTrolox yakaenzana (TEAC yakaenzana) chiitiko chakaenzana. CMS121 inodzivirira ischemia uye oxytosis mune phenotypic skrini muHT22 masero in vitro ine EC50 kukosha kwe7 uye 200 nM yekudzivirira iodoacetic acid- kana glutamate-induced cell death, zvichiteerana. Iyo zvakare inodzivirira, inoderedza uremu hwetsvo uye inoderedza kutaura kweTNF-α, caspase-1, uye inducible nit ric oxi de synthase (iNOS) muSAMP8 mouse muenzaniso wechirwere chetsvo chisingaperi chinosanganiswa nekukwegura nokukurumidza apo inoshandiswa pachiyero che 10 mg / kg pazuva kutanga pamwedzi mipfumbamwe yemakore.

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol musanganiswa unonziwo CMS121. Kurongeka kwekomboni yacho kunoratidza kuti inogona kunge iine zvimiro zvakasiyana uye zvinogona kushandiswa. Kuti unzwisise kukosha kwayo, zvinobatsira kuona mapoka anoshanda aripo uye kuongorora maitiro avo. Kuvapo kwerin'i yequinoline kunoratidza kuti komboni yacho inogona kunge ichishanda nebiologically. Quinoline-yakatorwa mamorekuru anozivikanwa neawo akasiyana biological zvimiro, kusanganisira antibacterial uye anti-kuzvimba mabasa. Kunamirwa kweboka re cyclopentyloxy kunogona kubatsira mukunyungudika kwekomboni kana kuwedzera chiitiko chayo chebhaibheri kuburikidza nekuita steric. Muzvidzidzo zveHT22 masero, CMS-121 yakaratidza zvakakosha neuroprotective mhedzisiro, inonyatso kudzivirira maseru aya kubva kune ischemia uye oxidative kukuvara. Uyezve, CMS-121 ine akakosha anti-kuzvimba zvivakwa, zvichiratidza kugona kwayo kugadzirisa mhinduro dzekuzvimba. Nekuita kudaro, CMS-121 ine mukana wekudzikisa kuzvimba mumhando dzakasiyana siyana uye nhengo. CMS-121 ine yakasimba pharmacological basa se inhibitor yeacetyl-CoA carboxylase 1 (ACC1). Iyo ine simba inhibitory mhedzisiro paACC1 inoita kuti ive komputa inovimbisa

 

 


  • FOB Mutengo:US 5 - 2000 / KG
  • Min.Order Quantity:1 KG
  • Supply Ability:10000 KG / pamwedzi
  • Port:Shanghai /Beijing
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    Product Detail

    Product Tags

    Product Name:CMS121

    Rimwe Zita:CMS-121;

    1,2-Benzenediol,4- [4-(cyclopentyloxy)-2-quinolinyl]-;

    4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);

    ACC,AcetylCoenzymeACarboxylase,chirwere,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121

    CAS NO.:1353224-53-9

    Muedzo: 98.0%Maminitsi

    Ruvara: Hupfu yeyero

    Packing: 25kg / DRUMS

    CMS121: A Breakthrough Neuroprotective Compound yeCognitive Health uye Beyond

    Nhanganyaya
    CMS121, iyo ine simba yakabva kune fisetin-flavonoid inowanikwa mumichero nemiriwo-yakabuda sechinhu chinoputika chine mabhenefiti akawanda ehutano hwetsinga, anti-kuchembera, uye metabolic regulation. Ichitsigirwa netsvakiridzo yepreclinical yakakura, CMS121 inoratidza kugona kunoshamisa mukugadzirisa chirwere cheAlzheimer (AD), kurasikirwa kwekunzwa kunoenderana nezera, uye kufutisa-kwakabatana nekusashanda zvakanaka kwemetabolism.

    Mabhenefiti Akakosha eCMS121

    1. Neuroprotection Kurwisa Chirwere cheAlzheimer
      CMS121 inotarisa fatty acid synthase (FASN), kuderedza lipid peroxidation-mutyairi mukuru wekuderera neuronal. Mune AD mbeva modhi, CMS121 yakadzoreredza kurasikirwa kwendangariro uye kuderera kwekuziva, nembeva dzakabatwa dzichiita zvakafanana nekutonga kune hutano mukuyedzwa kwemaitiro. Miedzo yemakiriniki iri kuitika kuti isimbise mhedzisiro iyi muvanhu.
    2. Kuchengetedza Kwekunzwa Kwakabatana Nezera
      CMS121 inodzivirira kubva pakuchembera kwekunzwa muSAMP8 mbeva, modhi yezera-rinoenderana nekunzwa kusagadzikana (ARHI). Iyo inochengetedza zvakanyanya sero rebvudzi remukati (IHC) synapses uye inodzikamisa zvikumbaridzo zvekunzwa pakati pe-frequencies (12-16 kHz), ichipa tariro yekudzikisa "yakavanzwa" kurasikirwa kwekunzwa.
    3. Metabolic uye Anti-Obesity Migumisiro
      Zvidzidzo zvenguva pfupi yapfuura zvinoratidza kugona kweCMS121 kudzosera kufutisa kunokonzerwa nekuchembera uye kugadzirisa hutano hwemetabolism. Mbeva dzakarapwa dzakaratidza kuderedzwa kwemafuta mashoma, kuwedzera kuonda, uye kuwedzera glucose metabolism, yakabatana neakakwira mazinga eanobatsira metabolites senge acetyl-CoA uye butyrate.

    Maitiro Ekuita

    • Inhibition yeFASN: Nekudzikisa mazinga eFASN, CMS121 inoderedza lipid peroxidation uye oxidative kusagadzikana, kudzivirira neurons uye cochlear masero kubva mukukuvadzwa.
    • Kuwedzerwa kweMitochondrial Basa: CMS121 inochengetedza acetyl-CoA mazinga, inotsigira simba reuropi metabolism uye gene expression.
    • Anti-Inflammatory Properties: Inodzvinyirira neuroinflammation uye microglial activation, yakakosha muAD uye metabolic kusagadzikana.

    Zvikumbiro uye Tsvakurudzo Inoenderera
    CMS121's oral bioavailability uye chengetedzo mbiri inoita kuti ive mumiriri anovimbisa we:

    • Kudzivirira neKurapwa kweAD: Kutarisira kutanga-danho rekuziva kudzikira.
    • Kunzwa Kurasika Kupindira: Kudzivirira kubva kuARHI muvanhu vakura.
    • Metabolic Syndrome Management: Kugadzirisa kufutisa uye insulin kuramba.

    Keywords
    Kuti uenderane nemaitiro ekutsvaga, zvinyorwa izvi zvinobatanidza mazwi makuru-anokosha akadai seneuroprotective compound,Kurapa kweAlzheimer,anti-aging supplement,kudzivirira kurasikirwa kwekunzwa,uyehutano hwemetabolism.

    Mhedziso
    CMS121 inomiririra shanduko yeparadigm mukugadzirisa zera-ane hukama neurological uye metabolic matambudziko. Inotsigirwa neyakasimba preclinical data uye inoenderera mberi nemiedzo yekiriniki, inopa nzira yakazara yekusimudzira mhando yehupenyu. Kuti uwane rumwe ruzivo nezve kutsvagisa kana kudyidzana, bata [Zita reKambani Yako], mutungamiri mune inovandudza neurohealth mhinduro.

     

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