Product Name:CMS121
Other Name:CMS-121;
1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);
ACC,AcetylCoenzymeACarboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer’s,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121
CAS NO.:1353224-53-9
Assay: 98.0%Min
Colour: Light yellow powder
Packing:25kg/DRUMS
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol is a compound also called CMS121. The compound’s structural complexity suggests it may have unique properties and potential uses. To understand its importance, it helps to identify the functional groups present and analyze their potential impact
CMS121 is a substituted quin oline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities. It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay. CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively. It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-α, caspase-1, and inducible nit ric oxi de synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol is a compound also called CMS121. The compound’s structural complexity suggests it may have unique properties and potential uses. To understand its importance, it helps to identify the functional groups present and analyze their potential impact. The presence of the quinoline ring suggests that the compound may be biologically active. Quinoline-derived molecules are known for their diverse biological properties, including antibacterial and anti-inflammatory activities. Attachment of the cyclopentyloxy group may contribute to the solubility of the compound or enhance its biological activity through steric effects. In studies on HT22 cells, CMS-121 has demonstrated significant neuroprotective effects, effectively protecting these cells from ischemia and oxidative damage. Furthermore, CMS-121 has significant anti-inflammatory properties, indicating its ability to modulate inflammatory responses. By doing so, CMS-121 has the potential to reduce inflammation in various tissues and organs. CMS-121 has strong pharmacological activity as an inhibitor of acetyl-CoA carboxylase 1 (ACC1). Its potent inhibitory effect on ACC1 makes it a promising compound
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