Bulk Wogonin Powder

Short Description:

Wogonin is an O-methylated flavonoid, a flavonoid compound found in Scutellaria baicalensis.Scutellaria baicalensis, also called Huang Qin, Baikal skullcap, Chinese skullcap, is a plant of scutellaria (Labiaceae), whose dry roots are recorded in Chinese pharmacopeia, Scutellaria baicalensis has been widely used by China, and its neighbors for thousands of years.

  • FOB Price: US $0.5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Payment Terms: L/C,D/A,D/P,T/T
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  • Product Detail

    Product Tags

    Product Name:Wogonin Bulk Powder

    Botanic Source:Scutellaria baicalensis

    CAS No:632-85-9

    Other Name:Vogoni,wagonin, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

    Specifications:≥98% HPLC

    Colour: Yellow powder with characteristic odor and taste

    GMO Status:GMO Free

    Packing: in 25kgs fiber drums

    Storage:Keep container unopened in cool, dry place,Keep away from strong light

    Shelf Life:24 months from date of production

    Scutellaria baicalensis contains a variety of chemical components, such as various flavonoids, diterpenoids, polyphenols, amino acids, volatile oil, sterol, benzoic acid, and so on. The dry roots contain more than 110 kinds of flavonoids such as baicalin, baicalein, wogonoside, and wogonin, which are the main active ingredient of Scutellaria baicalensis. Standardized extract like 80%-90% HPLC Baicalin, 90%-98% HPLC Baicalein, 90%-95% HPLC Wogonoside, and 5%-98% HPLC Wogonin


    In Vitro Activity:Wogonin inhibits PMA-induced COX-2 gene expression by inhibiting c-Jun expression and AP-1 activation in A549 cells[1]. Wogonin is an inhibitor of cyclin-dependent kinase 9 (CDK9) and block phosphorylation of the carboxy-terminal domain of RNA polymerase II at Ser. Thus, it reduces RNA synthesis and subsequently rapid downregulation of the short-lived anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) resulting in apoptosis induction in cancer cells. Wogonin directly binds to CDK9, presumably to the ATP-binding pocketa and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity. Wogonin preferentially inhibits CDK9 in malignant compared with normal lymphocytes. Wogonin is a also potent anti-oxidant capable to scavenge ?O2? [2]. Wogonin significantly inhibits the translocation of NFATc1 from the cytoplasm to the nucleus and its transcriptional activation activity. It also significantly inhibits osteoclast differentiation and decreases the transcription of osteoclast?associated immunoglobulin?like receptor, tartrate?resistant acid phosphatase and calcitonin receptor[4]. Wogonin Inhibits N-acetyltransferase Activity

    In Vivo Activity:Wogonin suppresses growth of human cancer xenografts in vivo. At doses lethal to tumor cells, wogonin shows no or little toxicity for normal cells and had also no obvious toxicity in animals[2]. Wogonin could induce apoptosis in murine sarcoma S180 thereby inhibiting the tumor growth both in vitro and in vivo[3]. An intraperitoneal injection of 200 mg/kg Wogonin could completely inhibit leukemia and CEM cells


    Cell experiments:

    A549 cells are culture in 24-well plate (1.2×105 cells/well) 1 day before wogonin treatment. DMSO or wogonin is added into A549 cells 1 h before PMA stimulation, and cells are incubated for another 6 h. Cells are collected by trypsin treatment and cell numbers are counted by using a hemocytometer and trypan blue exclusion method.


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