Taxifolin Powder Larch Tree Extract

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Product Name	Taxifolin Bulk Powder
IUPAC name	(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
Synonyms	Dihydroquercetin, Dihydro Quercetin, DHQ, Lavitol, Dahurian Larch extract, Larix gmelinii extract, larch tree extract, Dahurian Larch Tree Extract, taxifoline, dihydroquercétine
CAS Number	24198-97-8480-18-217654-26-1
Molecular Formula	C₁₅H₁₂O₇
Molecular Weight	304.3
Botanical Source	Larix sibirica
Specification	98%
Appearance	Light yellow or off-white powder
Functions	Antioxidant, Vascular Protection, Anti-cancer

Taxifolin, also called Dihydroquercetin, belongs to the flavanonol class of flavonoids, and flavanols are a class of polyphenols. It derives from quercetin powder.

Taxifolin (Dihydroquercetin) is an operative flavonoid, abundantly found in olive oil, grapes, citrus fruits, and onions.

Taxifolin molecule structure

Taxifolin vs Quercetin

To begin, Taxifolin and Quercetin are both flavonoids. The first difference between them is that they tend to come from different plant sources. Quercetin is found in red fruits’ bitter, sweet, fuzzy inner skin, other fruits like cherries and apples, vegetables like collards and broccoli, seeds, grains, and onions. Taxifolin, also known as Dihydroquercetin, is commonly found in onion extract, milk thistle extract, grapes, green tea extract, olive oil, and the tree bark of some conifers.

The most significant difference between Taxifolin and quercetin is that they have different chemical makeups. According to pre-clinical studies, Taxifolin has two additional hydrogen atoms per molecule, which makes it a more powerful antioxidant.

Taxifolin Sources

Dahurian larch, or the Larix gmelinii, or Gmelin larch, is a larch species native to eastern Siberia and adjacent northeastern Mongolia, northeastern China (Heilongjiang), South Korea, and North Korea.
Dahurian Larch forms enormous forests in the eastern Siberian taiga, growing at 50–1,200 m altitude on boggy and well-drained soils, including on the shallow grounds above permafrost. It is the northernmost tree in the world, as creeping forms of the trees in the tundra of the Taymyr Peninsula, and as comparatively vertical growing single trees.

Dahurian larch is grown occasionally in botanical gardens in Europe and North America; it is not an easy species to grow in areas with mild winters, adapted to a long winter break.

Taxifolin Specifications

80% Taxifolin powder HPLC
90% Taxifolin powder HPLC
95% Taxifolin powder HPLC
98% Taxifolin powder HPLC
99% Taxifolin powder HPLC

Dihydroquercetin-glucoside (DHQG)

Dihydroquercetin-glucoside (DHQG) is a stabilized polyphenol that activates the division of hair follicle stem cells while maintaining their differentiation properties. It’s considered an excellent option for hair loss treatment.

Dihydroquercetin vs Quercetin dihydrate

First, we can see that they have different molecular structures; Dihydroquercetin has two additional hydrogen atoms per molecule, whereas quercetin dihydrate is a synthetic chemical compound of quercetin with two crystal water.

They also have different functions; Quercetin dihydrate acts as a powerful antioxidant, anti-inflammatory drug, and an allergy symptom reliever. Additionally, this supplement may support cardiovascular health by reducing inflammation and oxidative stress.

However, like other chemicals, quercetin dihydrate can have side effects, including headaches, tingling in the arms and legs, and kidney damage in higher doses.

But with proper guidance, Quercetin dihydrate is safe and has no serious risks.

Vitamin C with Dihydroquercetin

But the human body does not synthesize vitamin C, so it must be obtained from diet and supplements; Vitamin C is a water-soluble compound that oxidizes quickly and is then excreted by the body, which significantly limits its effectiveness.

Now dihydroquercetin can function as an enhancer of vitamin C. Studies have shown that dihydroquercetin prevents the oxidation of vitamin C, helping to maintain its concentration and circulate it into the body.

Taxifolin Manufacturing Process

Taxifolin was extracted from larch bark or sawdust by alcohol; the simple steps are as below:

Taxifolin Benefits

As an Antioxidant

A study of dihydroquercetin on the peroxidation process of liposome membranes from egg phospholipids induced by ferrous sulfate or Fe(2+)-ascorbate system showed that dihydroquercetin antioxidant activity matches the antioxidant activity of alpha-tocopherol. Therefore, it was suggested that the mechanism of the antioxidant effect of dihydroquercetin is to scavenge lipid-free radicals.

For Vascular Protection

Hyperlipidemia is the most critical factor in developing atherosclerosis and coronary heart disease due to elevated cholesterol or low-density lipoprotein cholesterol levels. The results showed that Taxifolin maintained average lipid profiles in rat serum and liver and lipid excretion in feces after adding cholesterol-enriched diets. The in vivo results also showed that paclitaxel-treated animals had reduced liver total cholesterol levels and reduced levels of thiobarbituric acid-reactive substances in serum and liver.

For covid-19

In recent years, the antiviral activity of Taxifolin against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, has been investigated. After extensive research, researchers found that Taxifolin may be a potential SARS-CoV-2 master protease inhibitor with the lowest predicted IC50 value among many flavonoids. In addition, Taxifolin was one of 11 potential binders identified as a significant protease inhibitor of SARS-CoV-2 by another group of researchers who also performed an extensive computational screen. They also estimated low to moderate toxicity from off-target binding, improved drug similarity, and enhanced binding to the therapeutic target compared to co-crystallized ligands. These data suggest that Taxifolin is a possible anti-SARS-CoV-2 drug.

Anti-cancer

Taxifolin is a natural flavonoid that interacts with cell cycle regulators by activating the Wnt/ β -catenin signaling pathway, resulting in cell cycle arrest and tumor regression. According to several studies, Taxifolin has sound synergistic therapeutic effects in breast, lung, colorectal, liver, prostate, bone, and skin cancers.

Taxifolin side effects

There are no serious adverse effects reported yet; however, Taxifolin is recommended to be taken with or after meals since it has an astringent taste. Minor side effects, including gastrointestinal upset, headache, nausea, and dizziness, have been reported and resolved when the botanical is discontinued.

Taxifolin dosage

Nobel Prize-winning scientist Bollinger believes that eating 4-10 mg of taxifolin and vitamin C daily for a year can extend life expectancy by 20-25 years