J-147 Powder

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  • J-147 Powder

Short Description:

J147 is J-147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer’s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J-147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.


  • FOB Price: US $0.5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: SHANGHAI/BEIJING
  • Payment Terms: L/C,D/A,D/P,T/T
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    Product Detail

    Product Tags

    Product Name:J-147 Powder

    Other Name:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide],J-147, J147

    CAS No:1146963-51-0

    Assay:  99.0%Min

    Colour: White powder

    Packing:25kgs Drums

     

    J-147 is a particularly potent orally active neuroprotectant derived primarily from curcumin, the active ingredient in turmeric. Unlike curcumin, it crosses the blood-brain barrier very successfully.

    J-147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement.
    J-147 can readily pass the blood brain barrier (BBB). J-147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. J-147 has potential for the treatment of Alzheimer’s disease

    J-147 is a particularly potent orally active neuroprotectant derived primarily from curcumin, the active ingredient in turmeric. Unlike curcumin, it crosses the blood-brain barrier very successfully. Among them, J-147 works by binding to ATP synthase. Overproduction of ATP is associated with the aging process. In addition to increasing levels of the neurotransmitters NGF and BDNF, J-147 can control this. In addition, J-147 inhibits monoamine oxidase B and dopamine transporter. Promotes brain growth by increasing levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Most importantly, J-147 can promote the growth of new nerve cells, enhance the brain’s learning ability and memory, and improve cognitive function.

    Function:

    J-147 can readily pass the blood brain barrier (BBB).
    J-147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively.
    J-147 has potential for the treatment of Alzheimer’s disease (AD).
    J-147 has potential for the treatment of Alzheimer’s disease (AD).

    Application:

    J-147 is a synthetic compound whose primary mechanism of action involves mitochondrial enhancement, thereby optimizing energy production at the cellular level.  J-147 is designed to enhance the brain’s ability to repair and protect itself from age-related damage by improving mitochondrial function. Additionally, J-147 exhibits significant anti-inflammatory and antioxidant properties, further enhancing its potential neuroprotective effects.  J-147 can promote the growth of new nerve cells, enhance the brain’s learning ability and memory, and improve cognitive function.

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