Product Name:Lemairamin (WGX-50)

Other Name:2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-;Lemairamin (WGX-50)

CAS No:29946-61-0

Assay:  98.0%Min

Colour: White to off-white powder

Packing:25kg/DRUMS

 Lemairamin or Wgx50 is a natural compound extracted from chili peppers that has shown promising results in preventing Alzheimer’s disease. Studies have found that it can inhibit Aβ-induced neuronal apoptosis, reduce neuronal calcium toxicity, and reduce the accumulation of Aβ oligomers in the cerebral cortex. Additionally, wgx50 has been shown to improve cognitive performance in mice. Research suggests that wgx50 has the potential to prevent protein-protein assembly between amyloid molecules. Overall, wgx50 has the potential to prevent Alzheimer’s disease and may provide new avenues for the development of drugs targeting Aβ oligomers. Additionally, WGX-50 exhibits significant anti-inflammatory activity, which makes it a promising candidate for the treatment of inflammatory diseases. WGX-50 has been found to have significant effects on the skin, such as reducing wrinkles and improving skin elasticity. In addition to the natural compounds extracted from the plant Zanthoxylum bungeanum, there are currently more synthetic compounds that are used in various applications and are more suitable for the market.

Function:

1. Analgesic effect: Xanthoxylin has analgesic properties and can relieve pain symptoms. It can stimulate the body’s heat receptors, change the way pain is transmitted, and release endogenous pain-relieving substances, thereby reducing discomfort such as headaches and arthritis.
2. Antibacterial effect: Xanthophyllin has a certain antibacterial effect, which can inhibit the growth of bacteria and fungi. It is widely used in the food industry and health care products to keep food fresh and extend its shelf life.
3. Promote digestion: Xanthoxylum can stimulate the secretion of digestive glands, increase the secretion of gastric juice and saliva, thereby promoting the digestion process of food. It can also relieve GI problems like GI cramps and acid reflux.
4. Antioxidant effect: Xanthophyllin is a powerful antioxidant that can neutralize free radicals and reduce damage to cells caused by oxidative stress. This helps slow cellular aging, protects cardiovascular and neurological health, and prevents the development of chronic diseases.

Application:

Lemairamin is an amide compound extracted from the bark of the Zanthoxylum bungeanum plant. Currently used as a dietary supplement, it also acts as an agonist of the alpha7 nicotinic acetylcholine receptor (α7nAChR), which reduces neuroinflammation in Alzheimer’s disease.Currently used as a dietary supplement, it also acts as an agonist of the alpha7 nicotinic acetylcholine receptor (α7nAChR), which reduces neuroinflammation in Alzheimer’s disease, and is completely synthetic.Wgx50 has shown encouraging results in preclinical studies, including inhibiting Aβ-induced neuronal apoptosis, reducing neuronal calcium toxicity, reducing the accumulation of Aβ oligomers in the cerebral cortex, and improving cognitive performance in mice.