Mitoquinone

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  • Mitoquinone

Short Description:

Mitoquinone, also known as MitoQ, is a unique form of coenzyme Q10 (CoQ10) specifically designed to target and accumulate within mitochondria, the powerhouses of our cells.  Unlike traditional antioxidants, which may have difficulty penetrating the mitochondrial membrane, mitochondrial quinones are engineered to effectively reach this important organelle, where they exert their powerful antioxidant effects

Mitoquinone (444890-40-9) is a mitochondrial targeted antioxidant. Display heart and neuroprotective effects. 1 has shown beneficial effects in a mouse model of Alzheimer’s disease. 2-methoquinone protects pancreatic beta cells from oxidative stress and improves insulin secretion. 3 cell permeability. Methanesulfonate (Cat # 10-3914) and Methanesulfonate cyclodextrin complex (Cat # 10-3915) can also be provided

Mitoquinone, also known as MitoQ, is a unique form of coenzyme Q10 (CoQ10) specifically designed to target and accumulate within mitochondria, the powerhouses of our cells.  Unlike traditional antioxidants, which may have difficulty penetrating the mitochondrial membrane, mitochondrial quinones are engineered to effectively reach this important organelle, where they exert their powerful antioxidant effects. So, what makes mitocone different from other antioxidants?  The key is its ability to directly combat oxidative stress within mitochondria, where most harmful free radicals are produced.  By neutralizing these free radicals at their source, mitochondrial quinones play a vital role in protecting mitochondrial function and overall cellular health. Mitochondrial quinones target mitochondria by covalently binding to lipophilic triphenylphosphine cations. Due to the large mitochondrial membrane potential, cations accumulate up to 1,000 times more in cellular mitochondria than non-targeted antioxidants such as CoQ or its analogues, allowing the antioxidant moiety to block lipid peroxidation and protect mitochondria Protected from oxidative damage. By selectively blocking oxidative damage to mitochondria, it prevents cell death.From cardiovascular health to neurodegenerative diseases, mitocone has demonstrated its potential to reduce oxidative damage and support cell resiliency.

 


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
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    Product Detail

    Product Tags

    Product Name:Mitoquinone

    Other Name:Mito-Q；MitoQ；47BYS17IY0；

    UNII-47BYS17IY0；

    Mitoquinone cation；

    Mitoquinone ion；

    triphenylphosphanium；

    MitoQ; MitoQ10；

    10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-；

    CAS No:444890-41-9

    Specifications: 98.0%

    Colour: Brown powder with characteristic odor and taste

    GMO Status:GMO Free

    Packing: in 25kgs fiber drums

    Storage:Keep container unopened in cool, dry place,Keep away from strong light

    Shelf Life:24 months from date of production

    Mitoquinone (MitoQ) Product Description
    CAS#: 444890-41-9 | Purity: ≥99% | Storage: -20°C

    Product Overview

    Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant derived from ubiquinone (CoQ10), covalently linked to a lipophilic triphenylphosphonium (TPP) cation. This unique structure enables MitoQ to accumulate hundreds of times within mitochondria, specifically neutralizing reactive oxygen species (ROS) and protecting against oxidative damage .

    Key Features

    1. Mechanism of Action
      • Targeted Delivery: The TPP cation drives accumulation in mitochondria, enhancing protection against mitochondrial ROS overproduction .
      • Redox Activity: MitoQ’s ubiquinone moiety is reduced to ubiquinol, actively scavenging free radicals and restoring mitochondrial membrane potential .
    2. Proven Benefits in Research
      • Liver Protection: Reduces hepatic oxidative stress, inflammation, and fibrosis in cirrhotic models .
      • Neuroprotection: Improves mitochondrial function in Alzheimer’s and Parkinson’s disease models, attenuates neuronal death, and enhances motor performance .
      • Cardiometabolic Effects: Alleviates lipid-induced insulin resistance and improves glucose homeostasis under oxidative stress .
    3. In Vivo & In Vitro Efficacy
      • Dosage Flexibility: Effective in animal studies at 5–10 mg/kg (intraperitoneal) and 25–100 mg/kg (oral) .
      • Human Pharmacokinetics: Orally absorbed with detectable muscle concentrations (Cmax: ~3.84 µmol/g) at safe doses (160 mg) .

    Product Specifications

    • Form: Solid/Powder
    • Purity: ≥99% (HPLC/NMR verified)
    • Storage: -20°C (stable for 3 years in powder form; DMSO solutions: -80°C for ≤3 months) .
    • Packaging: 1 mg, 5 mg, 10 mg (custom orders available)

    Applications

    • Research Areas:
      • Neurodegenerative Diseases: Mitigates mitochondrial dysfunction in Parkinson’s and Alzheimer’s models .
      • Liver Fibrosis: Reduces hepatic inflammation and oxidative damage .
      • Metabolic Disorders: Improves insulin sensitivity under lipid stress .
      • Cardiovascular Protection: Attenuates ischemia-reperfusion injury and endothelial dysfunction .
    • Experimental Models:
      • Cell lines (e.g., SH-SY5Y, HK-2) and animal models (mice, rats) .

    Safety & Compliance

    • For Research Use Only: Not intended for human or clinical use .
    • Handling: Use personal protective equipment (gloves, lab coat); avoid inhalation or direct contact .
    • Solubility: Recommended in DMSO (stock solutions stable at -20°C) .

    Why Choose Our MitoQ?

    • High Purity: Rigorous quality control ensures ≥99% purity via TLC and NMR .
    • Global Supply: Available from multiple suppliers (e.g., XAQYBIO, GLPBIO, MedChemExpress) with fast shipping .
    • Scientific Backing: Cited in Nature, Cell, and Journal of Nanobiotechnology for robust experimental validation .

     Keywords

    Mitochondria-targeted antioxidant, MitoQ, CAS 444890-41-9, oxidative stress, neuroprotection, liver fibrosis, insulin resistance, ROS scavenger, CoQ10 derivative.

     

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