Trigonelline HCl is a natural alkaloid derived from fenugreek seeds, coffee beans, and medicinal herbs, renowned for its dual role in metabolic and neurological health. As a methylated form of nicotinic acid, it is scientifically validated to modulate cellular signaling pathways linked to blood sugar balance, neuroprotection, and longevity. This high-purity powder is widely used in dietary supplements, nootropic formulations, and functional food innovations.
Trigonelline HCl Powder: A Stable NAD+ Precursor for Enhanced Muscle Function and Longevity
(CAS: 6138-41-6 | Molecular Formula: C7H7NO2·HCl)
Product Overview
Trigonelline HCl Powder, a naturally occurring alkaloid derived from plants like fenugreek seeds (Trigonella foenum-graecum) and coffee beans, is a highly stable NAD+ precursor. It plays a critical role in combating age-related muscle decline (sarcopenia), enhancing mitochondrial function, and promoting cellular longevity through NAD+ biosynthesis .
Key Benefits
- NAD+ Boosting & Anti-Aging
Trigonelline effectively elevates intracellular NAD+ levels, a coenzyme essential for over 500 metabolic reactions, including mitochondrial energy production, DNA repair, and inflammation reduction. Its stability surpasses other NAD+ precursors like NMN and NR, making it ideal for long-term supplementation . - Muscle Health & Sarcopenia Prevention
Clinical studies link higher serum trigonelline levels to improved muscle mass, grip strength, and walking speed—key indicators of muscle health. It counteracts sarcopenia by enhancing satellite cell activity and reducing oxidative stress in aging muscles . - Metabolic & Neuroprotective Support
Trigonelline exhibits hypoglycemic, hypolipidemic, and neuroprotective properties. It aids in blood glucose regulation, reduces oxidative damage, and may mitigate neurodegenerative risks . - Antioxidant & Anti-Inflammatory Effects
By neutralizing free radicals and modulating inflammatory pathways, trigonelline protects against cellular damage and supports overall vitality .
Mechanism of Action
- NAD+ Synthesis: As a vitamin B3 metabolite, trigonelline converts into NAD+ via the salvage pathway, restoring cellular energy and resilience .
- Mitochondrial Optimization: Enhances mitochondrial efficiency by upregulating oxidative respiration proteins and reducing oxidative stress .
- Muscle Regeneration: Promotes protein synthesis and satellite cell activation, crucial for maintaining lean muscle mass .
Scientific Validation
- A 2024 study demonstrated that trigonelline supplementation increased NAD+ levels by 30% in muscle tissues, correlating with improved gait speed and grip strength in elderly subjects .
- Preclinical trials on diabetic rats showed trigonelline reduced blood glucose by 25% and kidney inflammation, highlighting its metabolic benefits .
- HPLC analysis confirms high purity (≥98%) and solubility in water, ensuring optimal bioavailability .
Usage & Dosage
- Recommended Intake: 250–500 mg daily, dissolved in water or mixed with smoothies.
- Safety: Non-toxic in clinical doses; complies with GMP standards. Avoid during pregnancy or if allergic to legumes.
Quality Assurance
- CAS Number: 6138-41-6 | Purity: ≥98% (HPLC-verified)
- Certifications: Manufactured under ISO guidelines, with third-party testing for heavy metals and microbial contaminants .
Why Choose Us?
As a leading supplier of longevity ingredients (e.g., NMN, NAD+ boosters), we ensure premium-grade trigonelline HCl powder with bulk customization options. Partner with us to enhance your supplement formulations and cater to the growing anti-aging market .
Keywords
NAD+ precursor, muscle function supplement, anti-aging powder, Trigonelline HCl CAS 6138-41-6, sarcopenia treatment, fenugreek extract, mitochondrial support
